Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Jeffrey D. St. Denis"'
Autor:
Kyle F. Biegasiewicz, Michelle L. Ingalsbe, Jeffrey D. St. Denis, James L. Gleason, Junming Ho, Michelle L. Coote, G. Paul Savage, Ronny Priefer
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 8, Iss 1, Pp 1814-1818 (2012)
Recently, a novel chiral cubane-based Schiff base ligand was reported to yield modest enantioselectivity in the Henry reaction. To further explore the utility of this ligand in other asymmetric organic transformations, we evaluated its stereoselectiv
Externí odkaz:
https://doaj.org/article/8359bd1cc5e6480bbd01fb670fbc4d17
Autor:
Benoit Carbain, Keisha Hearn, Ildiko Maria Buck, Burcu Anil, Sarah J. Cully, Gianni Chessari, Jane A. Endicott, John Lunec, Neil T. Thompson, Juan Castro, Roger J. Griffin, Rhian S. Holvey, Karen Haggerty, Charlotte H. Revill, Ruth H. Bawn, Stephen R. Wedge, Christiane Riedinger, Christopher N. Johnson, Bernard T. Golding, Lynsey Fazal, Ian R. Hardcastle, Mladen Vinkovic, Claire E. Jennings, Jong Sook Ahn, Bian Zhang, Pamela A. Williams, Celine Cano, Suzannah J. Harnor, Ben Cons, Stephen J. Hobson, E. Anscombe, Jeffrey D. St. Denis, Steven Howard, David R. Newell, Emiliano Tamanini, Nicola E. Wilsher, Miller Duncan Charles, Huw D. Thomas, Timothy J. Blackburn, Martin E.M. Noble, Judith Reeks, Yan Zhao, Luke Bevan
Publikováno v:
Journal of Medicinal Chemistry. 64:4071-4088
Inhibition of murine double minute 2 (MDM2)-p53 protein-protein interaction with small molecules has been shown to reactivate p53 and inhibit tumor growth. Here, we describe rational, structure-guided, design of novel isoindolinone-based MDM2 inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd2c962765a3d64c4d7d02d50fd31b0d
https://doi.org/10.1021/acs.jmedchem.0c02188
https://doi.org/10.1021/acs.jmedchem.0c02188
Autor:
Christopher William Murray, David C. Rees, Richard J. Hall, Jeffrey D. St. Denis, Tom D. Heightman
Publikováno v:
RSC Medicinal Chemistry
This Review describes the increasing demand for organic synthesis to facilitate fragment-based drug discovery (FBDD), focusing on polar, unprotected fragments. In FBDD, X-ray crystal structures are used to design target molecules for synthesis with n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18f66aee7eaec74f4b73592ae0e30c31
http://europepmc.org/articles/PMC8130625
http://europepmc.org/articles/PMC8130625
Publikováno v:
European Journal of Organic Chemistry. 2017:419-423
1,2-Aziridinyl propargylic amines have been obtained through a zinc-catalyzed multicomponent reaction. This process relies on the dimeric amino aldehyde assembly orchestrating the intramolecular 1,2-alkyne addition to an iminium ion. The resulting pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a5d69ce370409efe0846b48e0f2424c
https://doi.org/10.1002/ejoc.201601554
https://doi.org/10.1002/ejoc.201601554
Autor:
Christopher Charles Frederick Hamlett, Shimamura Tadashi, Steve Hiscock, Keisha Hearn, Juan Castro, T.G. Davies, Philip J. Day, James Edward Harvey Day, Yasuo Kodama, Kenichi Matsuo, Nicola G. Wallis, Amanda J. Price, Rhian S. Holvey, Valerio Berdini, Nick Palmer, Christopher N. Johnson, Gianni Chessari, Jeffrey D. St. Denis, Yoko Nakatsuru, Glyn Williams, Satoshi Fukaya, Satoru Ito
Publikováno v:
Cancer Research. 80:1039-1039
The ubiquitously expressed protein tyrosine phosphatase SHP2 is required for signalling downstream of receptor tyrosine kinases (RTKs) and plays a role in regulating many cellular processes. Recent advances have shown that genetic knockdown and pharm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c05e51817378141de98efd04bfce5ba9
https://doi.org/10.1158/1538-7445.am2020-1039
https://doi.org/10.1158/1538-7445.am2020-1039
Publikováno v:
Organic Letters. 17:5764-5767
Herein, we describe the rhodium-catalyzed C-H amination reaction of 1,2-boryl sulfamate esters derived from amphoteric α-boryl aldehydes. Depending on the substitution pattern of the boryl sulfamate ester, a diverse range of five- or six-membered ri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab6d5f54a82e4edb9b476b83f80f162d
https://doi.org/10.1021/acs.orglett.5b02861
https://doi.org/10.1021/acs.orglett.5b02861
Autor:
Jeffrey D. St. Denis, Gennady Poda, Shinya Adachi, Zhi He, Andrei K. Yudin, Alan J. Lough, C. Frank Lee, Sean K. Liew
Publikováno v:
Organic Letters. 17:5594-5597
Herein, we describe the bromomethyl acyl boronate linchpin--an enabling reagent for the condensation-driven assembly of novel bis(heteroaryl) motifs. This building block is readily accessible from commercially available starting materials. A variety
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18627845cca92f28b05361738ba8d0d4
https://doi.org/10.1021/acs.orglett.5b02741
https://doi.org/10.1021/acs.orglett.5b02741
Publikováno v:
ACS Catalysis. 5:5373-5379
Pairing of mutually reactive functional groups in the same molecule affords enabling opportunities in chemical synthesis. Kinetically amphoteric molecules exemplify this scenario and help avoid the pitfalls of protecting-group chemistry by exploiting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e84617408009b16e03efb005ff6584d1
https://doi.org/10.1021/acscatal.5b00790
https://doi.org/10.1021/acscatal.5b00790
Autor:
Aleksandra Holownia, Jonathan M. Elkins, C. Frank Lee, Shinya Adachi, Andrei K. Yudin, James M. Bennett, Jeffrey D. St. Denis
Described herein is the preparation of oxalyl boronate building blocks and their application for the construction of heterocycles. The oxalyl unit, readily accessible through commercially available starting materials, enables a modular approach for t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ac5f872a134e40bcf02b5f18e4ad02b
https://ora.ox.ac.uk/objects/uuid:859d7d70-a6a0-4a34-af71-44894cac8fd1
https://ora.ox.ac.uk/objects/uuid:859d7d70-a6a0-4a34-af71-44894cac8fd1
Autor:
Jennifer L. Hickey, Rebecca Courtemanche, Joy C. Y. Yu, Jeffrey D. St. Denis, Shinya Adachi, Benjamin H. Rotstein, Benjamin K. W. Chung, Andrei K. Yudin, Serge Zaretsky, Conor C. G. Scully
Publikováno v:
The Journal of Organic Chemistry. 79:9948-9957
The factors determining diastereoselectivity observed in the multicomponent conversion of amino acids, aziridine aldehyde dimers, and isocyanides into chiral piperazinones have been investigated. Amino acid-dependent selectivity for either trans- or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e039163b13e79e7dc90cfedd3718ff2
https://doi.org/10.1021/jo5018316
https://doi.org/10.1021/jo5018316