Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Jeffrey D. Serrill"'
Autor:
Daphne R. Mattos, Xuemei Wan, Jeffrey D. Serrill, Minh H. Nguyen, Ian R. Humphreys, Benoit Viollet, Amos B. Smith, Kerry L. McPhail, Jane E. Ishmael
Publikováno v:
Marine Drugs, Vol 20, Iss 7, p 418 (2022)
The mandelalides are complex macrolactone natural products with distinct macrocycle motifs and a bioactivity profile that is heavily influenced by compound glycosylation. Mandelalides A and B are direct inhibitors of mitochondrial ATP synthase (compl
Externí odkaz:
https://doaj.org/article/4550626820ff42e8ab85f1dcc9d4b4d9
Autor:
Xuemei Wan, Jeffrey D. Serrill, Ian R. Humphreys, Michelle Tan, Kerry L. McPhail, Ian G. Ganley, Jane E. Ishmael
Publikováno v:
Marine Drugs, Vol 16, Iss 3, p 77 (2018)
Our understanding of autophagy and lysosomal function has been greatly enhanced by the discovery of natural product structures that can serve as chemical probes to reveal new patterns of signal transduction in cells. Coibamide A is a cytotoxic marine
Externí odkaz:
https://doaj.org/article/fe0786cabd4a4fc5a4ddfbda9d9869a5
Autor:
Daphne R. Mattos, Marcus A. Weinman, Xuemei Wan, Cheri P. Goodall, Jeffrey D. Serrill, Kerry L. McPhail, Milan Milovancev, Shay Bracha, Jane E. Ishmael
Publikováno v:
Cell Stress Chaperones
Osteosarcoma is the most common type of bone cancer in dogs and humans, with significant numbers of patients experiencing treatment failure and disease progression. In our search for new approaches to treat osteosarcoma, we previously detected multip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f8496f7935f4b6e1e5d66f0cb7f6d0c
https://europepmc.org/articles/PMC9106791/
https://europepmc.org/articles/PMC9106791/
Autor:
Daphne R. Mattos, Jeffrey D. Serrill, Philip R. Gafken, Kerry L. McPhail, Walter K. Vogel, Jane E. Ishmael
Publikováno v:
Cancer Research. 82:3916-3916
Coibamide A is a cyclopeptide natural product with potent antiproliferative activity against cultured human cancer cells and subcutaneous U87-MG glioblastoma tumors in mice. We have recently determined that coibamide A binds to the Sec61 translocon c
Autor:
Ana Ruiz-Saenz, Christian E. Badr, Kerry L. McPhail, Jane E. Ishmael, Shinya Oishi, Soheila Kazemi, Brian Dolan, Jeffrey D. Serrill, Daphne R. Mattos, Ville O. Paavilainen, Shinsaku Kawaguchi, Mark M. Moasser
Publikováno v:
Biochem Pharmacol
Biochemical Pharmacology, 183:114317. Elsevier Inc.
Biochemical Pharmacology, 183:114317. Elsevier Inc.
Coibamide A is a potent cancer cell toxin and one of a select group of natural products that inhibit protein entry into the secretory pathway via a direct inhibition of the Sec61 protein translocon. Many Sec61 client proteins are clinically relevant
Autor:
Jane E. Ishmael, Juho Kellosalo, Anja O. Paatero, Shinya Oishi, Soheila Kazemi, Jeffrey D. Serrill, Uwe Richter, Shinsaku Kawaguchi, Ville O. Paavilainen, Daphne R. Mattos, Christopher C. Thornburg, Walter K. Vogel, Xuemei Wan, Dale Tranter, Kerry L. McPhail
Publikováno v:
ACS Chemical Biology
Coibamide A (CbA) is a marine natural product with potent antiproliferative activity against human cancer cells and a unique selectivity profile. Despite promising antitumor activity, the mechanism of cytotoxicity and specific cellular target of CbA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fca17dd4f6b29f56e39ec7d5d1c5124
http://hdl.handle.net/10138/319505
http://hdl.handle.net/10138/319505
Publikováno v:
Methods Mol Biol
Stem Cells and Tissue Repair ISBN: 9781071606544
Stem Cells and Tissue Repair ISBN: 9781071606544
The pancreas is composed of different cellular populations, organized into distinct functional units, including acinar clusters, islets of Langerhans, and the ductal system. As a result of research into diabetes, several optical techniques have been
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Scientific Reports
Scientific reports, vol 8, iss 1
Scientific Reports
Scientific reports, vol 8, iss 1
Cadherin-mediated cell-cell adhesion plays an important role in organ development and changes in cadherin expression are often linked to morphogenetic and pathogenic events. Cadherins interact with other intracellular components to form adherens junc
Autor:
Dale Tranter, Anja Paatero, Shinsaku Kawaguchi, Soheila Kazemi, Jeffrey D. Serrill, Juho Kellosalo, Walter K. Vogel, Uwe Richter, Christopher C. Thornburg, Shinya Oishi, Kerry L. McPhail, Jane E. Ishmael, Ville Paavilainen
Coibamide A (CbA) is a marine natural product with potent antiproliferative activity against human cancer cells and a unique selectivity profile. Despite promising antitumor activity, the mechanism of cytotoxicity and specific cellular target remain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78e9408df5769a427dc35c48a97723dc
https://doi.org/10.26434/chemrxiv.10092182
https://doi.org/10.26434/chemrxiv.10092182
Autor:
Shirley Parker-Nance, David A. Gallegos, Rosemary A. Dorrington, Jeffrey D. Serrill, Kerry L. McPhail, Jane E. Ishmael
Publikováno v:
Planta Medica. 81:S1-S381