Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Jeffrey D. Kittendorf"'
Autor:
Jeffrey D. Kittendorf, Eli B. Eisman, Christopher M. Rath, Jonathan D. Mortison, Douglas A. Hansen, Yeo Joon Yoon, David H. Sherman, Alison R. H. Narayan
Publikováno v:
Journal of the American Chemical Society. 135:11232-11238
A biocatalytic platform that employs the final two monomodular type I polyketide synthases (PKS) of the pikromycin pathway in vitro followed by direct appendage of D-desosamine and final C-H oxidation(s) in vivo was developed and applied toward the s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cbdf6aa9bf188e9843bfcfb26104605
https://doi.org/10.1021/ja404134f
https://doi.org/10.1021/ja404134f
Autor:
DeeAnne M. Goodenough-Lashua, Yi Chen Chen, H. D. Hollis Showalter, Allen F. Brooks, George A. Garcia, Jeffrey D. Kittendorf
Publikováno v:
Nucleic Acids Research
The enzyme tRNA-guanine transglycosylase (TGT) is involved in the queuosine modification of tRNAs in eukarya and eubacteria and in the archaeosine modification of tRNAs in archaea. However, the different classes of TGTs utilize different heterocyclic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93c25ae986716e74c27c4c4b550481ad
https://doi.org/10.1093/nar/gkq1188
https://doi.org/10.1093/nar/gkq1188
Autor:
Jamie B. Scaglione, David L. Akey, Rachel Sullivan, Jeffrey D. Kittendorf, Christopher M. Rath, Eung-Soo Kim, Janet L. Smith, David H. Sherman
Publikováno v:
Angewandte Chemie. 122:5862-5866
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a2705d2aec9de24448cc8f37065aee1
https://doi.org/10.1002/ange.201000032
https://doi.org/10.1002/ange.201000032
Autor:
David H. Sherman, Rachel A. Sullivan, Christopher M. Rath, Jamie B. Scaglione, Janet L. Smith, Eung-Soo Kim, David L. Akey, Jeffrey D. Kittendorf
Publikováno v:
Angewandte Chemie International Edition. 49:5726-5730
Tautomycetin (TMC) is a polyketide metabolite produced by Streptomyces sp. CK4412 and Streptomyces griseochromogenes.[1] This intriguing molecule was previously shown to possess activated T-cell specific immunosuppressive activity with a novel mode o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c33023182869acf9c65f4c2ccf81345c
https://doi.org/10.1002/anie.201000032
https://doi.org/10.1002/anie.201000032
Publikováno v:
Biochemistry. 48:11243-11251
The modified RNA base queuine [7-(4,5-cis-dihydroxy-1-cyclopenten-3-ylaminomethyl)-7-deazaguanine] is present in tRNA because of a unique base-exchange process catalyzed by tRNA-guanine transglycosylase (TGT). Previous studies have suggested the inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0cdaf3d5274dae47df631b5a6471a9d
https://doi.org/10.1021/bi901501a
https://doi.org/10.1021/bi901501a
Publikováno v:
Chemistry & Biology. 14(8):944-954
SummaryThe pikromycin polyketide synthase (PKS) is unique in its ability to generate both 12 and 14 membered ring macrolactones. As such, dissection of the molecular basis for controlling metabolic diversity in this system remains an important object
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b868c3753149e2372d4af1472cd1582
Publikováno v:
Current Opinion in Biotechnology. 17:597-605
Bacterial type I polyketide synthases (PKSs) are complex, multifunctional enzymes that synthesize structurally diverse and medicinally important natural products. Given their modular organization, the manipulation of type I PKSs holds tremendous prom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7838e8e92f2bc28831779e220c2105d9
https://doi.org/10.1016/j.copbio.2006.09.005
https://doi.org/10.1016/j.copbio.2006.09.005
Autor:
Jeffrey D. Kittendorf, Robert A. Fecik, John William Giraldes, Janet L. Smith, David H. Sherman, David L. Akey
Publikováno v:
Nature Chemical Biology. 2:531-536
Polyketides are a diverse class of natural products having important clinical properties, including antibiotic, immunosuppressive and anticancer activities. They are biosynthesized by polyketide synthases (PKSs), which are modular, multienzyme comple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33ae38a568e568d331a7744594b1bca6
https://doi.org/10.1038/nchembio822
https://doi.org/10.1038/nchembio822
Autor:
Robert A. Fecik, Janet L. Smith, David H. Sherman, Jeffrey D. Kittendorf, John William Giraldes, David L. Akey
Publikováno v:
Nature Chemical Biology. 2:537-542
Polyketides are a class of biologically active microbial and plant-derived metabolites that possess a high degree of structural and functional diversity and include many human therapeutics, among them anti-infective and anti-cancer drugs, growth prom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ff7421c04abcc14b1201ebaab48bbf5
https://doi.org/10.1038/nchembio824
https://doi.org/10.1038/nchembio824
Publikováno v:
Bioorganic Chemistry. 33:229-251
The vast majority of the ca. 100 chemically distinct modified nucleosides in RNA appear to arise via the chemical transformation of a genetically encoded nucleoside. Two notable exceptions are queuosine and pseudouridine, which are incorporated into
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79726fb60ba62595d3b306e2607463ae
https://doi.org/10.1016/j.bioorg.2005.01.001
https://doi.org/10.1016/j.bioorg.2005.01.001