Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Jeffrey D. Kearbey"'
Autor:
Ramesh Narayanan, Jinmai Jiang, Yuriy Gusev, Amanda Jones, Jeffrey D Kearbey, Duane D Miller, Thomas D Schmittgen, James T Dalton
Publikováno v:
PLoS ONE, Vol 5, Iss 10, p e13637 (2010)
Androgen receptor (AR) function is critical for the development of male reproductive organs, muscle, bone and other tissues. Functionally impaired AR results in androgen insensitivity syndrome (AIS). The interaction between AR and microRNA (miR) sign
Externí odkaz:
https://doaj.org/article/bf68859a00b34ef0bfca5ad59d70b707
Autor:
James T. Dalton, Jeffrey D. Kearbey, Duane D. Miller, Christopher C. Coss, Christina M. Barrett, Ramesh Narayanan, Deanna N. Parke, Amanda Jones, Karen A. Veverka, Mitchell S. Steiner, Ronald A. Morton
Publikováno v:
Endocrinology. 153:1070-1081
Androgen deprivation therapy (ADT) is the mainstay of treatment for advanced prostate cancer. ADT improves overall and disease-free survival rates, but long-term therapy is associated with severe side effects of androgen and estrogen depletion includ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48f92848da8d65177e0d47dcce91d684
https://doi.org/10.1210/en.2011-1608
https://doi.org/10.1210/en.2011-1608
Autor:
Chien-Ming Li, Jeffrey D. Kearbey, Charles B. Duke, Duane D. Miller, James T. Dalton, Sunjoo Ahn
Publikováno v:
Drug Metabolism and Disposition. 39:636-643
3-(1H-Indol-2-yl)phenyl)(3,4,5-trimethoxyphenyl)methanone (I-387) is a novel indole compound with antitubulin action and potent antitumor activity in various preclinical models. I-387 avoids drug resistance mediated by P-glycoprotein and showed less
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73f03dd0a2c540711d747ad25486d14a
https://doi.org/10.1124/dmd.110.036673
https://doi.org/10.1124/dmd.110.036673
Autor:
Duane D. Miller, Mitch A. Phelps, Peter J. Reiser, Christopher C. Coss, Jeffrey D. Kearbey, Wenqing Gao, James T. Dalton
Publikováno v:
Endocrinology. 146:4887-4897
The partial agonist activity of a selective androgen receptor modulator (SARM) in the prostate was demonstrated in orchidectomized rats. In the current study, we characterized the full agonist activity of S-3-(4-acetylamino-phenoxy)-2-hydroxy-2-methy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d04f86599e1517a8181c6f6ac4add967
https://doi.org/10.1210/en.2005-0572
https://doi.org/10.1210/en.2005-0572
Autor:
Vipin A. Nair, Duane D. Miller, Wenqing Gao, Albert F. Parlow, Kiwon Chung, Jeffrey D. Kearbey, James T. Dalton
Publikováno v:
Endocrinology. 145:5420-5428
Tissue-selective androgen receptor modulators (SARMs) demonstrate tissue selectivity in both castrated and intact male rats, behaving as partial agonists in androgenic tissues (i.e. prostate and seminal vesicle), but full agonists in anabolic tissues
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48848c00547c6b1902cda3a4af406364
https://doi.org/10.1210/en.2004-0627
https://doi.org/10.1210/en.2004-0627
Autor:
Duane D. Miller, Yali He, Karen A. Veverka, Huiping Xu, Jeffrey D. Kearbey, Wenqing Gao, Donghua Yin, James T. Dalton, Craig A. Marhefka, Kiwon Chung
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 304:1334-1340
The present study aimed to identify selective androgen receptor modulators (SARMs) with in vivo pharmacological activity. We examined the in vitro and in vivo pharmacological activity of four chiral, nonsteroidal SARMs synthesized in our laboratories
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f661ccb7e734eed64cda4e755e16483
https://doi.org/10.1124/jpet.102.040840
https://doi.org/10.1124/jpet.102.040840
Autor:
Yan Lu, Zhao Wang, Chien-Ming Li, James T. Dalton, Deanna N. Parke, Ramesh Narayanan, Wei Li, Sunjoo Ahn, Jeffrey D. Kearbey, Duane D. Miller
Formation of microtubules is a dynamic process that involves polymerization and depolymerization of αβ-tubulin heterodimers. Drugs that enhance or inhibit tubulin polymerization can destroy this dynamic process, arresting cells in the G2/M phase of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7247a1f0a6d180b59fb71f046c68e366
https://europepmc.org/articles/PMC3039446/
https://europepmc.org/articles/PMC3039446/
Autor:
Thomas D. Schmittgen, Ramesh Narayanan, Yuriy Gusev, Duane D. Miller, Amanda Jones, Jinmai Jiang, Jeffrey D. Kearbey, James T. Dalton
Publikováno v:
PLoS ONE
PLoS ONE, Vol 5, Iss 10, p e13637 (2010)
PLoS ONE, Vol 5, Iss 10, p e13637 (2010)
Androgen receptor (AR) function is critical for the development of male reproductive organs, muscle, bone and other tissues. Functionally impaired AR results in androgen insensitivity syndrome (AIS). The interaction between AR and microRNA (miR) sign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5f36f641426b021d521ee78ac622a8b
http://europepmc.org/articles/PMC2965097
http://europepmc.org/articles/PMC2965097
Autor:
Enrico Gerace, Hans Geyer, Jeffrey D. Kearbey, Andreas Thomas, Wilhelm Schänzer, Nils Schlörer, Simon Beuck, James T. Dalton, Mario Thevis
Publikováno v:
Drug testing and analysis. 2(11-12)
Selective androgen receptor modulators (SARMs) have great therapeutic potential in various diseases including cancer cachexia, sarcopenia, and osteoporosis, and the number of drug candidates has been growing over the last decade. The SARM drug candid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::292e66e88241cabfd1acdbf2c0e7617e
https://pubmed.ncbi.nlm.nih.gov/20967890
https://pubmed.ncbi.nlm.nih.gov/20967890
Autor:
Karen A. Veverka, Christina M. Barrett, James T. Dalton, Sharan Raghow, Jeffrey D. Kearbey, Duane D. Miller, Ramesh Narayanan, Jeetendra Eswaraka, Muralimohan Yepuru
Publikováno v:
The Journal of biological chemistry. 285(41)
Obesity is an epidemic problem affecting millions of people in the Western hemisphere and costs the United States economy more than $200 billion annually. Currently, there are no effective treatments to combat obesity. Recent studies have implicated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37598e385323ca6f13c5a9da310f7aa6
https://pubmed.ncbi.nlm.nih.gov/20657011
https://pubmed.ncbi.nlm.nih.gov/20657011