Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Jeffrey D. Butler"'
Autor:
Thomas P. Kenny, Richy C Y Chen, Jeffrey D. Butler, Kathryn G. Guggenheim, Patrick S.C. Leung, Ross L. Coppel, Christopher L. Bowlus, Min-Hua Tao, Shang-An Shu, Jinjun Wang, Aftab A Ansari, Guo-Xiang Yang, Phornnop Naiyanetr, Marshall M. Kaplan, Ana Lleo, Mark J. Kurth, M. Eric Gershwin
Publikováno v:
Hepatology. 57:1498-1508
Antimitochondrial antibodies (AMAs) directed against the lipoyl domain of the E2 subunit of pyruvate dehydrogenase (PDC-E2) are detected in 95% of patients with primary biliary cirrhosis (PBC) and are present before the onset of clinical disease. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ed06e2b0433463c5df14771e2b9b2ac
https://doi.org/10.1002/hep.26157
https://doi.org/10.1002/hep.26157
Autor:
Liping Meng, Thomas P. Kenny, Phornnop Naiyanetr, Roman Reiger, Aftab A. Ansari, Kathryn G. Guggenheim, Janice Pfeiff, Jeffrey D. Butler, Ross L. Coppel, Mark J. Kurth, Kit S. Lam, M. Eric Gershwin, Marcos Lopez-Hoyos, Patrick S.C. Leung
Publikováno v:
Journal of Autoimmunity. 37:209-216
Our laboratory has hypothesized that xenobiotic modification of the native lipoyl moiety of the major mitochondrial autoantigen, the E2 subunit of the pyruvate dehydrogenase complex (PDC-E2), may lead to loss of self-tolerance in primary biliary cirr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9f86fe3533e2b5ca05c83fe8528ceef
https://doi.org/10.1016/j.jaut.2011.06.001
https://doi.org/10.1016/j.jaut.2011.06.001
Publikováno v:
Chemistry - A European Journal. 16:9002-9005
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ae7752c3cdcc84b0c5ae14c0873921f
https://doi.org/10.1002/chem.201001492
https://doi.org/10.1002/chem.201001492
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:87-91
A developing therapy of ΔF508-CFTR, the most common CFTR mutation causing cystic fibrosis, employs correction of defective CFTR chloride channel gating by a ‘potentiator’ and of defective CFTR protein folding by a ‘corrector’. Based on SAR d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df81ff6445c469e882dffb2d9b733b2d
https://doi.org/10.1016/j.bmcl.2009.11.020
https://doi.org/10.1016/j.bmcl.2009.11.020
Publikováno v:
Cell. 137:110-122
SummaryThe transcriptional status of a gene can be maintained through multiple rounds of cell division during development. This epigenetic effect is believed to reflect heritable changes in chromatin folding and histone modifications or variants at t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32707b5e852d6233c5e45e3cea7d1a64
https://doi.org/10.1016/j.cell.2009.02.017
https://doi.org/10.1016/j.cell.2009.02.017
Publikováno v:
ChemInform. 45
A concise total synthesis of the complex indole alkaloid (±)-actinophyllic acid was accomplished by a sequence of reactions requiring only 10 steps from readily-available, known starting materials. The approach featured a Lewis acid-catalyzed cascad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73ab7c7f73766b2f6781f4fd07f56ee7
https://doi.org/10.1002/chin.201445223
https://doi.org/10.1002/chin.201445223
Publikováno v:
Tetrahedron. 70(27-28)
A concise total synthesis of the complex indole alkaloid (±)-actinophyllic acid was accomplished by a sequence of reactions requiring only 10 steps from readily-available, known starting materials. The approach featured a Lewis acid-catalyzed cascad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97e3f5c2a00cfff53de3c04be69f9031
https://pubmed.ncbi.nlm.nih.gov/24882888
https://pubmed.ncbi.nlm.nih.gov/24882888
Publikováno v:
Tetrahedron Letters. 50:5110-5112
An unexpected selectivity trend in the nitrile oxide cycloaddition and epoxidation reactions of 4,4-disubstituted cyclopentenes is reported. A variety of facially distinct, ‘X-’ and ‘Y-substituted’ cyclopentenes were investigated.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50eb076afbb23aa26c5616f08e46b463
https://doi.org/10.1016/j.tetlet.2009.06.100
https://doi.org/10.1016/j.tetlet.2009.06.100
Autor:
Elizabeth I. Parkinson, Claire E. Knezevic, Bruce K. Hua, Paul J. Hergenrother, Stephen F. Martin, Brett A. Granger, Ivan T. Jewett, Jeffrey D. Butler
Publikováno v:
Journal of the American Chemical Society. 135(35)
Actinophyllic acid is a biologically active indole alkaloid with a unique structural framework that incorporates five contiguous stereocenters. A total synthesis of (±)-actinophyllic acid has been completed that proceeds in only 10 steps from readil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4676bbd95715f556bd9e54b236c0b99
https://pubmed.ncbi.nlm.nih.gov/23972114
https://pubmed.ncbi.nlm.nih.gov/23972114
Autor:
Kathryn G. Guggenheim, Mark J. Kurth, Dean J. Tantillo, Jeffrey D. Butler, Phillip P. Painter, Lorsbach Beth
Publikováno v:
ChemInform. 42
Routes to structurally unique spiro-fused pyrazolidoylisoxazolines are reported. These methods start with monosubstituted hydrazines or hydrazides and utilize the nitrile oxide 1,3-dipolar cycloaddition reaction to generate the targeted spiro-fused b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::003fc603027753681916950bf16379c5
https://doi.org/10.1002/chin.201148135
https://doi.org/10.1002/chin.201148135