Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Jeffrey D. Bray"'
Autor:
Donald P. McDonnell, John D. Norris, Dmitri Kazmin, Scott K. Thompson, Jaclyn R. Patterson, Marlys Hammond, Walter Trizna, Nicholas J. Laping, Jeffrey D. Bray, Christine G. Schnackenberg, Daniel E. Frigo, Andrea B. Sherk
Androgens, through their actions on the androgen receptor (AR), are required for the development of the prostate and contribute to the pathologic growth dysregulation observed in prostate cancers. Consequently, androgen ablation has become an essenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95e83eb3282c67e787f8942ba5a7c35a
https://doi.org/10.1158/0008-5472.c.6498402
https://doi.org/10.1158/0008-5472.c.6498402
Autor:
Donald P. McDonnell, John D. Norris, Dmitri Kazmin, Scott K. Thompson, Jaclyn R. Patterson, Marlys Hammond, Walter Trizna, Nicholas J. Laping, Jeffrey D. Bray, Christine G. Schnackenberg, Daniel E. Frigo, Andrea B. Sherk
Supplementary Data from Development of a Small-Molecule Serum- and Glucocorticoid-Regulated Kinase-1 Antagonist and Its Evaluation as a Prostate Cancer Therapeutic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd34ad071b42869122db0e920ae8004b
https://doi.org/10.1158/0008-5472.22377012.v1
https://doi.org/10.1158/0008-5472.22377012.v1
Autor:
Huixiao Hong, Lei Xu, Roger Perkins, Abigail Jacobs, Susie Y. Dai, Jeffrey D. Bray, Wafa Harrouk, Richard S. Judson, Zhenqiang Su, Guangxu Zhou, Weigong Ge, Hong Fang, Thomas Colatsky, Ann M. Richard, Stephen C. Harris, Jason Aungst, Weida Tong, Christina T. Teng, Jie Shen
Publikováno v:
Toxicological Sciences. 135:277-291
Endocrine-active chemicals can potentially have adverse effects on both humans and wildlife. They can interfere with the body's endocrine system through direct or indirect interactions with many protein targets. Estrogen receptors (ERs) are one of th
Autor:
Emily J. Su, Toshiyuki Kakinuma, Jeffrey D. Bray, Diana Monsivais, Matthew T. Dyson, Mary Ellen Pavone, Antonia Navarro, Serdar E. Bulun
Publikováno v:
Fertility and Sterility. 98:117-125
Objective To define altered gene expression networks in endometriosis. Design Experiments using endometriotic tissues and primary cells. Setting Division of Reproductive Biology Research, Northwestern University. Patient(s) Premenopausal women. Inter
Autor:
Rakesh Nagilla, Sharada Manns, Eugene L. Stewart, Marlys Hammond, Tram H. Hoang, Scott K. Thompson, Walter Trizna, Chaya Duraiswami, Eugene T. Grygielko, Thuy B. Tran, James S. Frazee, Kevin P. Madauss, Johnson Latisha C, Shawn P. Williams, Lindsay E. Glace, David G. Washburn, Jeffrey D. Bray
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:4664-4668
We have designed and synthesized a novel series of pyrrolidinones as progesterone receptor partial agonists. Compounds from this series had improved AR selectivity, rat pharmacokinetic properties, and in vivo potency compared to the lead compound. In
Autor:
Eugene T. Grygielko, Eugene L. Stewart, Jeffrey D. Bray, Nicholas J. Laping, Charlene Wu, Shawn P. Williams, Thomas B. Stanley, Kevin P. Madauss, Su-Jun Deng, Steve A. Short, Anthony Sulpizio, Scott K. Thompson
Publikováno v:
Molecular Endocrinology. 21:1066-1081
Selective progesterone receptor modulators (SPRMs) have been suggested as therapeutic agents for treatment of gynecological disorders. One such SPRM, asoprisnil, was recently in clinical trials for treatment of uterine fibroids and endometriosis. We
Publikováno v:
Steroids. 71:792-798
The conformation of proteins often influences their functional activity. The effect of progesterone receptor ligands on the C-terminal conformation of the progesterone receptor affects the recruitment of transcriptional cofactors. These conformations
Publikováno v:
Steroids. 68:995-1003
Progestins play an important role in women’s health and are used in oral contraception, hormone therapy, and treatment of reproductive disorders. The effects of progestins upon gene expression in breast epithelium are poorly understood. In an attem
Publikováno v:
Genomics. 79:799-808
Translin-associated factor X (TRAX) is the predominantly cytoplasmic binding partner of TB-RBP/translin in mouse testis. Four mouse testis cDNAs encoding specific TRAX-interacting proteins were isolated from a yeast two-hybrid library screen. One nov
Publikováno v:
Journal of Biological Chemistry. 276:13256-13263
Trax (Translin-associated factor X) has been shown to interact with TB-RBP/Translin by its coimmunoprecipitation and in yeast two-hybrid assays. Here we demonstrate that Trax is widely expressed, does not bind to DNA or RNA, but forms heterodimers wi