Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Jeffrey D. Amack"'
Autor:
Osama Abdel-Razek, Amanda Marzouk, Madison MacKinnon, Edward T. Guy, Sonny A. Pohar, Emily Zhushma, Junjie Liu, Isabel Sia, Jason J. Gokey, Hwee Goon Tay, Jeffrey D. Amack
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Several of our internal organs, including heart, lungs, stomach, and spleen, develop asymmetrically along the left-right (LR) body axis. Errors in establishing LR asymmetry, or laterality, of internal organs during early embryonic development can res
Externí odkaz:
https://doaj.org/article/8d527d695b9147eaa09b2c2ae8c903a8
Autor:
Jun Wang, Holly R. Thomas, Robert G. Thompson, Stephanie C. Waldrep, Joseph Fogerty, Ping Song, Zhang Li, Yongjie Ma, Peu Santra, Jonathan D. Hoover, Nan Cher Yeo, Iain A. Drummond, Bradley K. Yoder, Jeffrey D. Amack, Brian Perkins, John M. Parant
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 12 (2022)
Externí odkaz:
https://doaj.org/article/5728cfeb2b524af68015cb523dbf9266
Autor:
Kadeen Forrest, Alexandria C. Barricella, Sonny A. Pohar, Anna Maria Hinman, Jeffrey D. Amack
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Vital internal organs display a left-right (LR) asymmetric arrangement that is established during embryonic development. Disruption of this LR asymmetry—or laterality—can result in congenital organ malformations. Situs inversus totalis (SIT) is a
Externí odkaz:
https://doaj.org/article/c24dc028abaf4dbf97fab1d7b2f02466
Autor:
Jeffrey D. Amack
Publikováno v:
Cell Communication and Signaling, Vol 19, Iss 1, Pp 1-16 (2021)
Abstract Epithelial-mesenchymal transition (EMT) refers to a process in which epithelial cells lose apical-basal polarity and loosen cell–cell junctions to take on mesenchymal cell morphologies and invasive properties that facilitate migration thro
Externí odkaz:
https://doaj.org/article/7dd39b6ca52e4b8cac1415d8a0bdf58a
Autor:
Peu Santra, Jeffrey D. Amack
Publikováno v:
Disease Models & Mechanisms, Vol 14, Iss 7 (2021)
The vacuolar-type H+-ATPase (V-ATPase) is a multi-subunit proton pump that regulates cellular pH. V-ATPase activity modulates several cellular processes, but cell-type-specific functions remain poorly understood. Patients with mutations in specific V
Externí odkaz:
https://doaj.org/article/ca4778cbee7243e6bf3a0794a577e727
Autor:
Manush Saydmohammed, Hisato Yagi, Michael Calderon, Madeline J. Clark, Timothy Feinstein, Ming Sun, Donna B. Stolz, Simon C. Watkins, Jeffrey D. Amack, Cecilia W. Lo, Michael Tsang
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
The actin-based motor Myosin1d is needed to establish left–right asymmetry in Drosophila. Here the authors show that myosin 1d has a role in lumen formation, vacuole trafficking and left-right asymmetry establishment during zebrafish development.
Externí odkaz:
https://doaj.org/article/cfc943d44642444da1d90ae13429f6f8
Autor:
Miao Yu, Yu Liu, Jing Li, Brianna N. Natale, Shuqin Cao, Dongliang Wang, Jeffrey D. Amack, Huaiyu Hu
Publikováno v:
Biology Open, Vol 5, Iss 11, Pp 1662-1673 (2016)
Mutations in the extracellular matrix protein eyes shut homolog (EYS) cause photoreceptor degeneration in patients with retinitis pigmentosa 25 (RP25). Functions of EYS remain poorly understood, due in part to the lack of an EYS gene in mouse. We inv
Externí odkaz:
https://doaj.org/article/7d185410e32e4043ada5890bf3acc609
Autor:
Jeffrey D. Amack
Publikováno v:
Molecular Reproduction and Development. 89:579-596
Cilia are hair-like structures that project from the surface of cells. In vertebrates, most cells have an immotile primary cilium that mediates cell signaling, and some specialized cells assemble one or multiple cilia that are motile and beat synchro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c310cbe59ffa7d8a5330c8dc18e913c4
https://doi.org/10.1002/mrd.23650
https://doi.org/10.1002/mrd.23650
Autor:
Agnik Dasgupta, Matthias Merkel, Madeline J Clark, Andrew E Jacob, Jonathan Edward Dawson, M Lisa Manning, Jeffrey D Amack
Publikováno v:
eLife, Vol 7 (2018)
How epithelial cell behaviors are coordinately regulated to sculpt tissue architecture is a fundamental question in biology. Kupffer’s vesicle (KV), a transient organ with a fluid-filled lumen, provides a simple system to investigate the interplay
Externí odkaz:
https://doaj.org/article/e2e073458c1c4c08b7a0a37f5b987a28
Autor:
Plansky Hoang, Adriana M. Archilla, A. Gulhan Ercan-Sencicek, Andrew Kowalczewski, Wenzhong Liu, Jeffrey D. Amack, Zhen Ma, Tackla S. Winston, Abha R. Gupta, Maria I. Kontaridis, Shiyang Sun, Stephanie M. Lemus
Publikováno v:
Stem Cell Reports
Summary Emerging technologies in stem cell engineering have produced sophisticated organoid platforms by controlling stem cell fate via biomaterial instructive cues. By micropatterning and differentiating human induced pluripotent stem cells (hiPSCs)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2a702c3c2ff822addec04354cc247ef
https://doi.org/10.1016/j.stemcr.2021.03.013
https://doi.org/10.1016/j.stemcr.2021.03.013