Výsledky vyhledávání - "Jeffrey D Winkler"

Akademický článek

Sex steroids regulate skin pigmentation through nonclassical membrane-bound receptors

Autor: Christopher A Natale, Elizabeth K Duperret, Junqian Zhang, Rochelle Sadeghi, Ankit Dahal, Kevin Tyler O'Brien, Rosa Cookson, Jeffrey D Winkler, Todd W Ridky

Publikováno v: eLife, Vol 5 (2016)

The association between pregnancy and altered cutaneous pigmentation has been documented for over two millennia, suggesting that sex hormones play a role in regulating epidermal melanocyte (MC) homeostasis. Here we show that physiologic estrogen (17�

Externí odkaz: https://doaj.org/article/5a94f997ed32420a82a0f13011bcb7fa

Zobrazit plný text záznamu

Akademický článek

The Suramin Derivative NF449 Interacts with the 5-fold Vertex of the Enterovirus A71 Capsid to Prevent Virus Attachment to PSGL-1 and Heparan Sulfate.

Autor: Yorihiro Nishimura, Noel P McLaughlin, Jieyan Pan, Sara Goldstein, Susan Hafenstein, Hiroyuki Shimizu, Jeffrey D Winkler, Jeffrey M Bergelson

Publikováno v: PLoS Pathogens, Vol 11, Iss 10, p e1005184 (2015)

NF449, a sulfated compound derived from the antiparasitic drug suramin, was previously reported to inhibit infection by enterovirus A71 (EV-A71). In the current work, we found that NF449 inhibits virus attachment to target cells, and specifically blo

Externí odkaz: https://doaj.org/article/3297c7bc6d0a44e89e49960f6999e85e

Zobrazit plný text záznamu

Akademický článek

PPT1 inhibition enhances the antitumor activity of anti–PD-1 antibody in melanoma

Publikováno v: JCI Insight, Vol 5, Iss 17 (2020)

New strategies are needed to enhance the efficacy of anti–programmed cell death protein antibody (anti–PD-1 Ab) in cancer. Here, we report that inhibiting palmitoyl-protein thioesterase 1 (PPT1), a target of chloroquine derivatives like hydroxych

Externí odkaz: https://doaj.org/article/1eb69c668c3c47a4ac86a114612e04f4

Zobrazit plný text záznamu

Akademický článek

CDK4/6 and autophagy inhibitors synergistically induce senescence in Rb positive cytoplasmic cyclin E negative cancers

Autor: Smruthi Vijayaraghavan, Cansu Karakas, Iman Doostan, Xian Chen, Tuyen Bui, Min Yi, Akshara S. Raghavendra, Yang Zhao, Sami I. Bashour, Nuhad K. Ibrahim, Meghan Karuturi, Jing Wang, Jeffrey D. Winkler, Ravi K. Amaravadi, Kelly K. Hunt, Debu Tripathy, Khandan Keyomarsi

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)

CDK4/6-Cyclin D pathway is often deregulated in cancer; therefore specific inhibitors have been developed. Here the authors show that treatment with CDK4/6 inhibitors activate autophagy in breast cancer cells; thus, combination of such inhibitors wit

Externí odkaz: https://doaj.org/article/29244e97db3b4325b02bb495622f99c7

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání