Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Jeffrey D Singer"'
Autism risk gene Cul3 alters neuronal morphology via caspase-3 activity in mouse hippocampal neurons
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
Autism Spectrum Disorders (ASDs) are neurodevelopmental disorders (NDDs) in which children display differences in social interaction/communication and repetitive stereotyped behaviors along with variable associated features. Cul3, a gene linked to AS
Externí odkaz:
https://doaj.org/article/b9774902bf764aa3bff2635fdb873842
Autor:
Qiang-Qiang Xia, Angela K Walker, Chenghui Song, Jing Wang, Anju Singh, James A Mobley, Zhong X Xuan, Jeffrey D Singer, Craig M Powell
Publikováno v:
PLoS ONE, Vol 18, Iss 7, p e0283299 (2023)
Autism Spectrum Disorder (ASD) is a developmental disorder in which children display repetitive behavior, restricted range of interests, and atypical social interaction and communication. CUL3, coding for a Cullin family scaffold protein mediating as
Externí odkaz:
https://doaj.org/article/3822b5b797b9457ab8bef3f0813fc6a5
Publikováno v:
Immunohorizons
The E3 ubiquitin ligase cullin 3 (Cul3) is critical for invariant NKT (iNKT) cell development, as iNKT cells lacking Cul3 accumulate in the immature developmental stages. However, the mechanisms by which Cul3 mediates iNKT cell development remain unk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2df20182d54e7b31264f340e64aafaf
https://europepmc.org/articles/PMC10122431/
https://europepmc.org/articles/PMC10122431/
Publikováno v:
Cell and Tissue Research. 385:49-63
Cullin 3 (Cul3) has recently been implicated in a multitude of different processes, including the oxidative stress response, autophagy, tumorigenesis, and differentiation. To investigate the role of Cul3 in mammary gland development, we created a mou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a630eb47374ec68ab9ef0db0f4143fec
https://doi.org/10.1007/s00441-021-03456-1
https://doi.org/10.1007/s00441-021-03456-1
Publikováno v:
Cell and tissue research. 385(1)
Cullin 3 (Cul3) has recently been implicated in a multitude of different processes, including the oxidative stress response, autophagy, tumorigenesis, and differentiation. To investigate the role of Cul3 in mammary gland development, we created a mou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a72199a6930d7dcbcf91eef25548dd7e
https://pubmed.ncbi.nlm.nih.gov/33825963
https://pubmed.ncbi.nlm.nih.gov/33825963
Autor:
Benjamin J. Swanson, John M. Asara, Audrey J. Lazenby, Jeffrey D. Singer, Wei Gong, Haitao Wen, Laura E. Herring, Lupeng Li, Zhibin Zhang, Xinghui Li
Publikováno v:
The Journal of Experimental Medicine
Li et al. show that OGT-mediated STAT3 O-GlcNAcylation, which is modulated by CUL3-Nrf2 signaling, negatively regulates STAT3 phosphorylation and IL-10 production in macrophages and exacerbates experimental colitis and colitis-associated cancer.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::769d89cd3c0890b953f2b224ae4b6135
http://europepmc.org/articles/PMC5379975
http://europepmc.org/articles/PMC5379975
Autor:
Frederick W. Quelle, Curt D. Sigmund, Ko-Ting Lu, Jeffrey D. Singer, James A. McCormick, Henry L. Keen, Larry N. Agbor, Anand R. Nair, Jing Wu, Deborah R. Davis
Patients with mutations in Cullin-3 (CUL3) exhibit severe early onset hypertension but the contribution of the smooth muscle remains unclear. Conditional genetic ablation of CUL3 in vascular smooth muscle (S-CUL3KO) causes progressive impairment in r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a5f224eac7626721b7cc665c8365457
https://europepmc.org/articles/PMC6675584/
https://europepmc.org/articles/PMC6675584/
Autor:
Kavya Tallapaka, Adam Bournazos, Jordan Blondelle, Jane T. Seto, Madison Clark, Jeffrey D. Singer, Majid Ghassemian, J. Laitila, Stephan Lange
Publikováno v:
JCI Insight. 4
Nemaline myopathy is a congenital neuromuscular disorder characterized by muscle weakness, fiber atrophy, and presence of nemaline bodies within myofibers. However, understanding of the underlying pathomechanisms is lacking. Recently, mutations in KB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8db5caa59b10ea5c657aaa1a96344d30
https://doi.org/10.1172/jci.insight.125665
https://doi.org/10.1172/jci.insight.125665
Autor:
Christoph Kuppe, Marcus J. Moeller, Jeffrey D. Singer, Catherina A. Cuevas, Turgay Saritas, Rafael Kramann, Mohammed Z. Ferdaus, James A. McCormick, Jürgen Floege
Publikováno v:
Scientific Reports
Scientific Reports, 9:4596. Nature Publishing Group
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports, 9:4596. Nature Publishing Group
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Cullin 3 (CUL3) is part of the ubiquitin proteasomal system and controls several cellular processes critical for normal organ function including the cell cycle, and Keap1/Nrf2 signaling. Kidney tubule-specific Cul3 disruption causes tubulointerstitia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56d518651b19367ddac95a621d5f6d55
http://europepmc.org/articles/PMC6418206
http://europepmc.org/articles/PMC6418206
Autor:
Lauren N. Miller, Mohammed Z. Ferdaus, Jeffrey D. Singer, Turgay Saritas, Larry N. Agbor, James A. McCormick, Curt D. Sigmund
Mutations in the ubiquitin ligase scaffold protein Cullin 3 (CUL3) cause the disease familial hyperkalemic hypertension (FHHt). In the kidney, mutant CUL3 (CUL3-Δ9) increases abundance of With-No-Lysine [K] Kinase 4 (WNK4), with excessive activation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::131aa6c643c915c18ebf31ca966c8c1e