Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Jeffrey D Rudolf"'
Autor:
Zining Li, Sana Jindani, Volga Kojasoy, Teresa Ortega, Erin M. Marshall, Khalil A. Abboud, Sandra Loesgen, Dean J. Tantillo, Jeffrey D. Rudolf
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 20, Iss 1, Pp 1320-1326 (2024)
Eunicellane diterpenoids are a unique family of natural products containing a foundational 6/10-bicyclic framework and can be divided into two main classes, cis and trans, based on the configurations of their ring fusion at C1 and C10. Previous studi
Externí odkaz:
https://doaj.org/article/073d4566b5b3463cbfbc80becdef62e1
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 20, Iss 1, Pp 2720-2721 (2024)
Externí odkaz:
https://doaj.org/article/715506c5551642099e8687aa6d3c0a33
Autor:
Jeffrey D. Rudolf, Sandra Loesgen
Publikováno v:
ACS Central Science, Vol 10, Iss 3, Pp 511-513 (2024)
Externí odkaz:
https://doaj.org/article/7952fb3f99104b51a10fe2e44caa7775
Publikováno v:
Communications Chemistry, Vol 5, Iss 1, Pp 1-8 (2022)
Crystal structure elucidation of terpene synthases plays an important role to understand the sequence-structure-function relationships of this enzyme class. Here, the authors determine the crystal structure of bacterial terpene synthase Tpn2, probe t
Externí odkaz:
https://doaj.org/article/f597421e33344233a4e461a7fd8580b6
Autor:
Liao-Bin Dong, Jeffrey D. Rudolf, Dingding Kang, Nan Wang, Cyndi Qixin He, Youchao Deng, Yong Huang, K. N. Houk, Yanwen Duan, Ben Shen
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Thioplatensimycin (thioPTM) and thioplatencin (thioPTN) are recently discovered thiocarboxylic acid congeners of the antibacterial compounds PTM and PTN. Here, the authors identify a thioacid cassette encoding PtmA3 and PtmU4 that are responsible for
Externí odkaz:
https://doaj.org/article/e89626e016aa4682b96d98ed37e5b624
Autor:
Thibault Annaval, Jeffrey D. Rudolf, Chin-Yuan Chang, Jeremy R. Lohman, Youngchang Kim, Lance Bigelow, Robert Jedrzejczak, Gyorgy Babnigg, Andrzej Joachimiak, George N. Phillips, Ben Shen
Publikováno v:
ACS Omega, Vol 2, Iss 8, Pp 5159-5169 (2017)
Externí odkaz:
https://doaj.org/article/f93dca24cda6473ab72e51f3e5444751
Autor:
Zengyuan Wang, Qian Yang, Jingyi He, Haixin Li, Xingming Pan, Zining Li, Hui-Min Xu, Jeffrey D. Rudolf, Dean J. Tantillo, Liao-Bin Dong
Terpene cyclization, one of the most complex chemical reactions in nature, is generally catalyzed by two classes of terpene cyclases (TCs). Cytochrome P450s that act as unexpected TC-like enzymes are known but are very rare. Here, we genome-mined a c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a0e0738226982d985d6b103f703236c
https://doi.org/10.26434/chemrxiv-2023-wc46q
https://doi.org/10.26434/chemrxiv-2023-wc46q
Publikováno v:
Organic & Biomolecular Chemistry. 20:8833-8837
Bnd4 catalyzes the first committed step in the biosynthesis of the bacterial diterpenoid benditerpenoic acid and was the first eunicellane synthase identified from nature. We investigated the catalytic roles of the aromatic residues in the active sit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bfc3ad11ea4c8b30e60f7db3b3923fe
https://doi.org/10.1039/d2ob01931k
https://doi.org/10.1039/d2ob01931k
Autor:
Jeffrey A. van Santen, Alison H. Hughes, Roger G. Linington, Jeffrey D. Rudolf, David P. Fewer, Elisabeth M.-L. Janssen, Trevor N. Clark, Tyler A. Alsup, Claire H. Fergusson, Dasha Iskakova, Jonathan Parra, Katherine R. Duncan, Ella F. Poynton, Sylvia Soldatou, Caitlin A. McCadden, Emily McMann
Publikováno v:
Nucleic Acids Research
Within the natural products field there is an increasing emphasis on the study of compounds from microbial sources. This has been fuelled by interest in the central role that microorganisms play in mediating both interspecies interactions and host-mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::649477591caa8aa7b97596d064977407
http://europepmc.org/articles/PMC8728154
http://europepmc.org/articles/PMC8728154
Autor:
I‐Hsuan Chen, Ting Cheng, Yung‐Lin Wang, Szu‐Jo Huang, Yu‐Hsuan Hsiao, Yi‐Ting Lai, Shu‐Ing Toh, John Chu, Jeffrey D. Rudolf, Chin‐Yuan Chang
Publikováno v:
Chembiochem : a European journal of chemical biology.
Capreomycidine (Cap) is a nonproteinogenic amino acid and building block of nonribosomal peptide (NRP) natural products. We report the formation and activation of Cap in capreomycin biosynthesis. CmnC and CmnD catalyzed hydroxylation and cyclization,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6eb676d4b2362b292c4db47e3f67752
https://pubmed.ncbi.nlm.nih.gov/36278314
https://pubmed.ncbi.nlm.nih.gov/36278314