Výsledky vyhledávání - "Jeffrey D Roizen"

Akademický článek

CLEC16A regulates splenocyte and NK cell function in part through MEK signaling.

Autor: Rahul Pandey, Marina Bakay, Heather S Hain, Bryan Strenkowski, Barakat Z B Elsaqa, Jeffrey D Roizen, Jake A Kushner, Jordan S Orange, Hakon Hakonarson

Publikováno v: PLoS ONE, Vol 13, Iss 9, p e0203952 (2018)

CLEC16A is implicated in multiple autoimmune diseases. We generated Clec16a inducible knockout (KO) mice to examine the functional link between CLEC16A auto-inflammation and autoimmunity. Clec16a KO mice exhibited weight loss and thymic and splenic a

Externí odkaz: https://doaj.org/article/563c11486a71460587c4bdf84af47c84

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A Pilot Randomized Clinical Trial of Intranasal Oxytocin to Promote Weight Loss in Individuals With Hypothalamic Obesity

Autor: Shana E McCormack, Zi Wang, Kristin L Wade, Anna Dedio, Nicolette Cilenti, Julia Crowley, Franziska Plessow, Vaneeta Bamba, Jeffrey D Roizen, Yaoguang Jiang, Jack Stylli, Arjun Ramakrishnan, Michael L Platt, Karuna Shekdar, Michael J Fisher, Victoria L Vetter, Matthew Hocking, Rui Xiao, Elizabeth A Lawson

Publikováno v: Journal of the Endocrine Society. 7

Context Hypothalamic obesity is a rare, treatment-resistant form of obesity. In preliminary studies, the hypothalamic hormone oxytocin (OXT) has shown promise as a potential weight loss therapy. Objective To determine whether 8 weeks of intranasal OX

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::67d85a1c8d1b0d04f2b620bbe03c1564
https://doi.org/10.1210/jendso/bvad037

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Improved genetic risk scoring algorithm for type 1 diabetes prediction

Autor: Hui‐Qi Qu, Jingchun Qu, Joseph Glessner, Yichuan Liu, Frank Mentch, Xiao Chang, Michael March, Jin Li, Jeffrey D. Roizen, John J. Connolly, Patrick Sleiman, Hakon Hakonarson

Publikováno v: Pediatr Diabetes

Precise risk prediction of type 1 diabetes (T1D) facilitates early intervention and identification of risk factors prior to irreversible beta-islet cell destruction, and can significantly improve T1D prevention and clinical care. Sharp et al. (2019)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2431e39fe0a32d996c1eab0baaaebe5
https://doi.org/10.1111/pedi.13310

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High dose dietary vitamin D allocates surplus calories to muscle and growth instead of fat via modulation of myostatin and leptin signaling

Autor: Caela Long, Zahra Tara, Alex Casella, Julian Mark, Jeffrey D. Roizen

Obesity is the leading proportional cause for diabetes, heart disease and cancer. Obesity occurs because the body stores surplus calories as fat. Fat cells secrete a hormone, leptin, that modulates energy balance at the brain. Changes in fat mass are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7ee8ca9ebd0a80d813e9604a2ddcde9f
https://doi.org/10.1101/2022.05.19.492715

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Differential Frequency of CYP2R1 Variants Across Populations Reveals Pathway Selection for Vitamin D Homeostasis

Autor: Caela Long, Lauren O'Lear, Meizan Lai, Ilana Caplan, Jingman Zhou, Jeffrey D. Roizen, Alex Casella, Michael A. Levine

Publikováno v: J Clin Endocrinol Metab

Context Normal vitamin D homeostasis is necessary to ensure optimal mineral metabolism. Dietary insufficiency of vitamin D and the lack of sunlight each have well understood roles in vitamin D deficiency; however, the extent to which common genetic v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8d13de933dbfc652df4fa8cf43adb29
https://doi.org/10.1210/clinem/dgaa056

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ODP576 A pilot randomized clinical trial of intranasal oxytocin to promote weight loss in children, adolescents, and adults with hypothalamic obesity

Autor: Vaneeta Bamba, Nicolette Cilenti, Julia Crowley, Anna E Dedio, Michael J Fisher, Matthew C Hocking, Elizabeth A Lawson, Franziska Plessow, Jeffrey D Roizen, Victoria L Vetter, Kristin L Wade, Zi C Wang, Rui Xiao, Shana McCormack

Publikováno v: Journal of the Endocrine Society. 6:A519-A519

Many individuals with brain tumors affecting the hypothalamus and pituitary gain weight excessively after tumor treatment. There is currently no FDA-approved treatment for this condition, which is called hypothalamic obesity. In animals and in some p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c38606810927406b575454839d94af87
https://doi.org/10.1210/jendso/bvac150.1079

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Insights into non-autoimmune type 1 diabetes with 13 novel loci in low polygenic risk score patients

Autor: Michael E. March, Hakon Hakonarson, Hui-Qi Qu, Patrick M. A. Sleiman, Jeffrey D. Roizen, Jingchun Qu, Xiao Chang, Lifeng Tian, John J. Connolly, Jonathan P. Bradfield, Joseph T. Glessner

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports

With polygenic risk score (PRS) for autoimmune type 1 diabetes (T1D), this study identified T1D cases with low T1D PRS and searched for susceptibility loci in these cases. Our hypothesis is that genetic effects (likely mediated by relatively rare gen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8cb23b7566f957bd96164179e603687
https://doi.org/10.1038/s41598-021-94994-9

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Genetics of Low Polygenic Risk Score Type 1 Diabetes Patients: rare variants in 22 novel loci

Autor: Lifeng Tian, Michael E. March, Jingchun Qu, Xiao Chang, Patrick M. A. Sleiman, Hui-Qi Qu, Hakon Hakonarson, Joseph T. Glessner, Jonathan P. Bradfield, Jeffrey D. Roizen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d8fbeaffb37b0826d2d4413a0bbd8388
https://doi.org/10.1101/2020.10.13.20211987

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