Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Jeffrey D Hermes"'
Representing high throughput expression profiles via perturbation barcodes reveals compound targets.
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 2, p e1005335 (2017)
High throughput mRNA expression profiling can be used to characterize the response of cell culture models to perturbations such as pharmacologic modulators and genetic perturbations. As profiling campaigns expand in scope, it is important to homogeni
Externí odkaz:
https://doaj.org/article/9ef656e486684a0cb10a586c64ff5b5d
Autor:
Brad Sherborne, Andrea M. Peier, Cesear Corona, Ahmad Sadruddin, David P. Lane, Fernando J. Ferrer-Gago, Kaustav Biswas, Dawn Thean, Arun Chandramohan, Tomi K. Sawyer, Christopher J. Brown, Nicolas Boyer, Lan Ge, Tsz Ying Yuen, Lin Yan, John R. Frost, Hung Yi Kristal Kaan, Scott D. Edmondson, Jeffrey D. Hermes, Anthony W. Partridge, Xue Er Lee, Ruchia Duggal, Chad Zimprich, Matthew B. Robers, Charles W. Johannes
Publikováno v:
ACS chemical biology. 16(2)
Macrocyclic peptides open new opportunities to target intracellular protein-protein interactions (PPIs) that are often considered nondruggable by traditional small molecules. However, engineering sufficient membrane permeability into these molecules
Autor:
Elisabeth MacColl, Paul Zuck, Victor N. Uebele, Michelle F Homsher, Jeffrey D. Hermes, Jason Cassaday, Jennifer Nothstein
Publikováno v:
SLAS Technology. 22:485-492
Automated mechanism of action studies are introducing the need for tailored compound delivery, which can be challenging for standard compound management procedures. Jump dilution assays investigating inhibitor reversibility require compound delivery
Autor:
Douglas C. Beshore, Stephen Day, Jason Cassaday, Michelle F. Homsher, Brian Squadroni, David Pechter, Michelle Smith, Lei Ma, Jeffrey D. Hermes, Elizabeth Mohammed, Michelle Hartnett, Paul Zuck, Michael F.A. Finley, Victor N. Uebele, Fredrick Monsma
Publikováno v:
SLAS Discovery. 22:1060-1066
Agonist shift assays feature cross-titrations of allosteric modulators and orthosteric ligands. Information generated in agonist shift assays can include a modulator's effect on the orthosteric agonist's potency (alpha) and efficacy (beta), as well a
Autor:
Adam B Weinglass, Nicholas B Hastings, Bradley S Sherborne, Jennifer M. Johnston, Andrew D Howard, Maria Webb, Steven L. Colletti, Clemens Vonrhein, Kevin J. Lumb, Srivanya Tummala, Frank K Brown, Jennifer Hadix, Hubert Josien, Stephen M. Soisson, Guo Yan, Harry R. Chobanian, John Wang, Michael W. Miller, Brande Thomas-Fowlkes, Dawn L. Hall, Jeffrey D. Hermes, Thu Ho, Barbara Pio, Payal R. Sheth, Sujata Sharma, Maria Kornienko, Samantha J Allen, Sangita B. Patel, Jerry Di Salvo, Sarah Souza, Gérard Bricogne, Christopher W Plummer, Jun Lu, Noel Byrne
Publikováno v:
Nature Structural & Molecular Biology. 24:570-577
Clinical studies indicate that partial agonists of the G-protein-coupled, free fatty acid receptor 1 GPR40 enhance glucose-dependent insulin secretion and represent a potential mechanism for the treatment of type 2 diabetes mellitus. Full allosteric
Autor:
Bharti Gajera, Albert Rauch, Paul Zuck, Sylvie Jezequel-Sur, Michael F.A. Finley, Jason Cassaday, Jeffrey D. Hermes, Victor N. Uebele, Brian Squadroni
Publikováno v:
SLAS Technology. 22:195-205
In the triage of hits from a high-throughput screening campaign or during the optimization of a lead compound, it is relatively routine to test compounds at multiple concentrations to determine potency and maximal effect. Additional follow-up experim
Autor:
Jay A. Grobler, Paul Zuck, Victor N. Uebele, Jeffrey D. Hermes, Vandna Munshi, Gregory C. Adam, Juncai Meng, Ming-Tain Lai, John A. McCauley, Eric N. Johnson
Publikováno v:
SLAS Discovery. 20:606-615
HIV-1 protease (PR) represents one of the primary targets for developing antiviral agents for the treatment of HIV-infected patients. To identify novel PR inhibitors, a label-free, high-throughput mass spectrometry (HTMS) assay was developed using th
Autor:
Michelle F, Homsher, Douglas C, Beshore, Jason, Cassaday, Brian, Squadroni, Elizabeth, Mohammed, Michelle, Hartnett, Stephen, Day, Lei, Ma, David, Pechter, Michelle D, Smith, Fredrick, Monsma, Paul, Zuck, Michael F, Finley, Victor N, Uebele, Jeffrey D, Hermes
Publikováno v:
SLAS discovery : advancing life sciences RD. 22(8)
Agonist shift assays feature cross-titrations of allosteric modulators and orthosteric ligands. Information generated in agonist shift assays can include a modulator's effect on the orthosteric agonist's potency (alpha) and efficacy (beta), as well a
Autor:
Kelly-Ann S. Schlegel, Peter S. Kutchukian, Lee Warren, Sophie Parmentier-Batteur, Jason Cassaday, Victor N. Uebele, Brian C. Magliaro, Brian Squadroni, Danielle M. Hurzy, Eric N. Johnson, J. Chris Culberson, Gregory O'Donnell, Adam Amoss, Fiona Thomson, Michael F.A. Finley, Paul Zuck, Andrew J. Cooke, Danette Pascarella, Jeffrey D. Hermes
N-methyl-d-aspartate receptors (NMDARs) mediate glutamatergic signaling that is critical to cognitive processes in the central nervous system, and NMDAR hypofunction is thought to contribute to cognitive impairment observed in both schizophrenia and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83ee89032dec0bd4c1bf64d0fea584c0
https://eprints.gla.ac.uk/146530/1/146530.pdf
https://eprints.gla.ac.uk/146530/1/146530.pdf
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 2, p e1005335 (2017)
PLoS Computational Biology
PLoS Computational Biology
High throughput mRNA expression profiling can be used to characterize the response of cell culture models to perturbations such as pharmacologic modulators and genetic perturbations. As profiling campaigns expand in scope, it is important to homogeni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3ead4b7b172121b105841bafee32695