Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Jeffrey D, Browning"'
Autor:
Xiaorong Fu, Justin A. Fletcher, Stanisław Deja, Melissa Inigo-Vollmer, Shawn C. Burgess, Jeffrey D. Browning
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 9 (2023)
BACKGROUND Hepatic de novo lipogenesis (DNL) and β-oxidation are tightly coordinated, and their dysregulation is thought to contribute to the pathogenesis of nonalcoholic fatty liver (NAFL). Fasting normally relaxes DNL-mediated inhibition of hepati
Externí odkaz:
https://doaj.org/article/759d699f134e4b338a78e82adc8cb48b
Autor:
Xiaorong Fu, Stanisław Deja, Justin A. Fletcher, Norma N. Anderson, Monika Mizerska, Gonçalo Vale, Jeffrey D. Browning, Jay D. Horton, Jeffrey G. McDonald, Matthew A. Mitsche, Shawn C. Burgess
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
Fat synthesis is necessary for normal physiology, but its dysregulation contributes to the pathology of many diseases. Here, the authors report a high-resolution mass spectrometry approach that quantifies fat synthesis flux in humans and mice followi
Externí odkaz:
https://doaj.org/article/b1cab25a3bac4392a10db218cc30d323
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 9, Pp 1685-1694 (2018)
It is a challenge to assess metabolic dysregulation in fatty liver of human patients prior to clinical manifestations. Here, we recruited obese, but otherwise healthy, subjects to examine biochemical processes in the liver with simple triglyceride ac
Externí odkaz:
https://doaj.org/article/9118e872584e43d796c87543bd99b66c
Autor:
Minh‐da Le, Yiling Wu, Jarett D. Berry, Jeffrey D. Browning, James A. de Lemos, Ian J. Neeland, Ildiko Lingvay
Publikováno v:
Diabetes, Obesity and Metabolism. 25:586-595
To evaluate the associations between liver fat content and cardiometabolic parameters to explore potential threshold values that define metabolically healthy liver fat content, and to examine the association of liver fat content with cardiovascular e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bcc450e989687c0a49bf5aabf878343
https://doi.org/10.1111/dom.14905
https://doi.org/10.1111/dom.14905
Autor:
Stanislaw Deja, Blanka Kucejova, Xiaorong Fu, Jeffrey D. Browning, Jamey D. Young, Shawn Burgess
Publikováno v:
Metabolites, Vol 11, Iss 5, p 279 (2021)
Ketogenesis occurs in liver mitochondria where acetyl-CoA molecules, derived from lipid oxidation, are condensed into acetoacetate (AcAc) and reduced to β-hydroxybutyrate (BHB). During carbohydrate scarcity, these two ketones are released into circu
Externí odkaz:
https://doaj.org/article/6564245739284e7ca315cb3f38beba41
Autor:
null Minh‐da Le, null Yiling Wu, null Jarett D. Berry, null Jeffrey D. Browning, null James A deLemos, null Ian J. Neeland, null Ildiko Lingvay
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c51255529f8d1d1ac81b781ba64a0653
https://doi.org/10.1111/dom.14905/v2/response1
https://doi.org/10.1111/dom.14905/v2/response1
Autor:
Joao A.G. Duarte, Filipa Carvalho, Mackenzie Pearson, Jay D. Horton, Jeffrey D. Browning, John G. Jones, Shawn C. Burgess
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 12, Pp 2541-2553 (2014)
Intracellular lipids and their synthesis contribute to the mechanisms and complications of obesity-associated diseases. We describe an NMR approach that provides an abbreviated lipidomic analysis with concurrent lipid biosynthetic fluxes. Following d
Externí odkaz:
https://doaj.org/article/d1a0b5ff917147909aec369f2ae03115
Autor:
Santhosh Satapati, Nishanth E. Sunny, Blanka Kucejova, Xiaorong Fu, Tian Teng He, Andrés Méndez-Lucas, John M. Shelton, Jose C. Perales, Jeffrey D. Browning, Shawn C. Burgess
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 6, Pp 1080-1092 (2012)
The manner in which insulin resistance impinges on hepatic mitochondrial function is complex. Although liver insulin resistance is associated with respiratory dysfunction, the effect on fat oxidation remains controversial, and biosynthetic pathways t
Externí odkaz:
https://doaj.org/article/ba94d3a6be124555b8986617945852ef
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 3, Pp 577-586 (2012)
Fasting promotes triglyceride (TG) accumulation in lean tissues of some animals, but the effect in humans is unknown. Additionally, fasting lipolysis is sexually dimorphic in humans, suggesting that lean tissue TG accumulation and metabolism may diff
Externí odkaz:
https://doaj.org/article/07ed2735d1f04be6911ba0cdb43dd8f5
Autor:
Jeffrey D. Browning, Jay D. Horton
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 11, Pp 3359-3363 (2010)
Proprotein convertase, subtilisin/kexin type 9 (PCSK9), a key regulator of plasma LDL-cholesterol (LDL-c) and cardiovascular risk, is produced in liver and secreted into plasma where it binds hepatic LDL receptors (LDLR), leading to their degradation
Externí odkaz:
https://doaj.org/article/8a09b1d0e4174b03a618f2008ecd05a9