Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Jeffrey Clough"'
Autor:
Brystana G, Kaufman, David, Anderson, William K, Bleser, David B, Muhlestein, Nathan, Smith, Jeffrey, Clough, Mark B, McClellan, Robert, Saunders
Publikováno v:
Journal of healthcare management / American College of Healthcare Executives. 66(3)
Accountable care organizations (ACOs) need confidence in their return on investment to implement changes in care delivery that prioritize seriously ill and high-cost Medicare beneficiaries. The objective of this study was to characterize spending on
Autor:
Jeffrey Clough, Elliott B. Grossbard, Gary Park, David Lau, Somasekhar Bhamidipati, Weiqun Li, Rajinder Singh, Muhammad Baluom, David J. Sweeny
Publikováno v:
Drug Metabolism and Disposition. 38:1166-1176
The metabolism of the spleen tyrosine kinase inhibitor N4-(2,2-dimethyl-3-oxo-4-pyrid[1,4]oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethyoxyphenyl)-2,4-pyrimidinediamine (R406) and its oral prodrug N4-(2,2-dimethyl-4-[(dihydrogenphosphonoxy)methyl]-3-oxo-5-
Autor:
Alexander B. Rossi, Hui Li, Donald G. Payan, Jeffrey Clough, Ankush Argade, Somasekhar Bhamidipati, Esteban Masuda, Rajinder Singh, Christina Coquilla, Holger Keim, Catherine Sylvain, Sarkiz D. Issakani, David Carroll
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(10)
Here we report the optimization of small molecule inhibitors of human mast cell degranulation via anti-IgE-mediated tryptase release following cross-linking and activation of IgE-loaded FceR1 receptors. The compounds are selective upstream inhibitors
Autor:
Somasekhar Bhamidipati, Sarkiz D. Issakani, David Carroll, Donald G. Payan, Vanessa Taylor, Catherine Sylvain, Holger Keim, Rajinder Singh, Hui Li, Jeffrey Clough, Ellen Herlaar, Brian Wong, Sylvia Braselmann, Esteban Masuda, Ankush Argade, Haoran Zhao
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(10)
Using cultured human mast cells (CHMC) the optimization of 2,4-diaminopyrimidine compounds leading to 22, R406 is described. Compound 22 is a potent upstream inhibitor of mast cell degranulation and its mechanism of action is via inhibition of Syk ki
Autor:
Shaoqing Chen, Stuart Lam, Romeo Ciabatti, Joaquim Trias, Richard White, Gianpaolo Candiani, C J Hackbarth, Jeffrey W. Jacobs, Stefano Donadio, Eric M. Gordon, Jeffrey Clough, Gabriella Romano
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:3409-3414
Thiazole peptide GE2270 A (1) possesses potent antimicrobial activity against many gram-positive pathogens, including methicillin resistant Staphylococcus aureus (S. aureus, MRSA; MIC(90)=0.06 microg/mL) and vancomycin resistant Enterococcus spp. (VR
Autor:
Jeffrey Clough, Neil I. Goldfarb
Publikováno v:
American Journal of Medical Quality. 22:383-385
Autor:
Gary Park, John McLaughlin, Vadim Markovtsov, Andrea Reitsma, Donald G. Payan, Shuling Fang, Chian Liu, Kazuya Shimoda, Elizabeth Tonkin, Haruko Shimoda, Jason Romero, Marina Gelman, Takuya Matsunaga, Allan Torneros, Rajinder Singh, Caroline Low, Wayne Lang, Jeffrey Clough, Polly Pine, Somasekhar Bhamidipati, Stacey Siu, Kotaro Shide, Matt Duan, Takuro Kameda, Yasumichi Hitoshi
Publikováno v:
Blood. 117(25)
The activating mutations in JAK2 (including JAK2V617F) that have been described in patients with myeloproliferative neoplasms (MPNs) are linked directly to MPN pathogenesis. We developed R723, an orally bioavailable small molecule that inhibits JAK2
Autor:
Gary Park, Elizabeth Tonkin, Donald G. Payan, George Clemens, John R. McLaughlin, Wayne Lang, Chiang Liu, Andrea Reitsma, Caroline M. R. Low, Polly Pine, Allan Torneros, Stacey Siu, Ruby Daniel, Vadim Markovtsov, Sacha Holland, Jason Romero, Vanessa Taylor, Shuling Fang, David Sweeney, Jeffrey Clough, Matt Duan, Marina Gelman, Yasumichi Hitoshi, Somasekhar Bhamidipati, Rajinder Singh
Publikováno v:
Blood. 112:3721-3721
Recent advances in understanding the role of JAK2 V617F mutation in Bcr-Abl negative myeloproliferative (MPD) diseases pathogenesis opened up a possibility to develop highly targeted therapies against these debilitating ailments. We used a Ba/F3 cell
Autor:
Betty Chang, Elizabeth Tonkin, Gary Park, Marina Gelman, Sohasekhar Bhamidipati, Wayne Lang, David Sweeney, Shuling Fang, Polly Pine, Roy Frances, Stacey Huynh, Donald G. Payan, John R. McLaughlin, Rena Bahjat, Vanessa Taylor, Diane Yu, Jeffrey Clough, Ruby Daniel, Vadim Markovtsov, Rajinder Singh, Sacha Holland, Yasumichi Hitoshi
Publikováno v:
Blood. 110:3550-3550
Limited options provided by the current standard of care for the patients suffering from myeloproliferative diseases (MPDs) prompted an extensive search for the underlying molecular mechanisms of these disorders. Recent discovery of a single activati
Publikováno v:
Current Medical Research & Opinion; Mar2008, Vol. 24 Issue 3, p815-819, 5p