Výsledky vyhledávání - "Jeffrey C. Stevens"

Mass Cytometry: A Highly Multiplexed Single-Cell Technology for Advancing Drug Development

Autor: Kondala R Atkuri, Hendrik Neubert, Jeffrey C. Stevens

Publikováno v: Drug Metabolism and Disposition. 43:227-233

Advanced single-cell analysis technologies (e.g., mass cytometry) that help in multiplexing cellular measurements in limited-volume primary samples are critical in bridging discovery efforts to successful drug approval. Mass cytometry is the state-of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f0594e742d51815f598a05410ac2b79
https://doi.org/10.1124/dmd.114.060798

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Preclinical and Clinical Evidence for the Collaborative Transport and Renal Secretion of an Oxazolidinone Antibiotic by Organic Anion Transporter 3 (OAT3/SLC22A8) and Multidrug and Toxin Extrusion Protein 1 (MATE1/SLC47A1)

Autor: Wade J. Adams, Steven R. Cox, Larissa M. Balogh, Vikas Kumar, Yurong Lai, Kathleen E. Sampson, Timothy G. Brayman, Jeffrey C. Stevens

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 334:936-944

N-({(5S)-3-[4-(1,1-dioxidothiomorpholin-4-yl)-3,5-difluorophenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)acetamide (PNU-288034), an oxazolidinone antibiotic, was terminated in phase I clinical development because of insufficient exposure. Analysis of the d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19f4afda482ad8ae252c07ca00ab1804
https://doi.org/10.1124/jpet.110.170753

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A Humanized UGT1 Mouse Model Expressing the UGT1A1*28 Allele for Assessing Drug Clearance by UGT1A1-Dependent Glucuronidation

Autor: Hongliang Cai, Nghia Nguyen, Deirdre Beaton La Placa, Shujuan Chen, Vincent Peterkin, Robert H. Tukey, Kathy Hotz, Young Sun Yang, Jeffrey C. Stevens

Publikováno v: Drug Metabolism and Disposition. 38:879-886

Humanized mice that express the human UDP-glucuronosyltransferase (UGT) 1 locus have been developed in a Ugt1-null background as a model to improve predictions of human UGT1A-dependent drug clearance. Enzyme kinetic parameters (K(m) and V(max)) and p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::770cc86df07bb79276fbcae4124d599e
https://doi.org/10.1124/dmd.109.030130

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Editorial

Autor: Jeffrey C, Stevens

Publikováno v: Drug Metabolism and Disposition. 46:88-88

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61cc2d31a15d879227d98f824e60c4d6
https://doi.org/10.1124/dmd.117.079772

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Developmental Changes in Human Liver CYP2D6 Expression

Autor: Karthika Divakaran, Matthew J. Zaya, Ronald N. Hines, Karen J. Regina, Sandra A. Marsh, Min Le, Jeffrey C. Stevens

Publikováno v: Drug Metabolism and Disposition. 36:1587-1593

Within the human cytochrome P450 family, specific forms show developmental expression patterns that can affect drug clearance, efficacy, and safety. The objective of this study was to use dextromethorphan O-demethylase activity and quantitative Weste

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::164742db0889facb0a6311caad855c5f
https://doi.org/10.1124/dmd.108.021873

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New perspectives on the impact of cytochrome P450 3A expression for pediatric pharmacology

Autor: Jeffrey C. Stevens

Publikováno v: Drug Discovery Today. 11:440-445

Advances in the basic and clinical sciences of drug actions and safety have been applied almost exclusively to the largest demographic patient group--adults. Metabolism-dependent drug clearance is not only a primary determinant for obtaining efficaci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a887387f429f2d0ff4f78cdc2c83208
https://doi.org/10.1016/j.drudis.2006.03.002

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Developmental Expression of the Major Human Hepatic CYP3A Enzymes

Autor: Sevasti B. Koukouritaki, Jason Manro, Chungang Gu, Ronald N. Hines, Peter J. Tandler, Jeffrey C. Stevens, Matthew J. Zaya

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 307:573-582

The human cytochrome P4503A forms show expression patterns subject to developmental influence. CYP3A7 and CYP3A4 are generally classified as the major fetal and adult liver forms, respectively. However, characterization of CYP3A4, -3A5, and -3A7 deve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be42896c806cbe2c27236154ba7292a7
https://doi.org/10.1124/jpet.103.054841

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The Changing Environment of Graduate and Postdoctoral Training in Drug Metabolism: Viewpoints from Academia, Industry, and Government

Autor: Dennis C. Dean, Peter C. Preusch, Jeffrey C. Stevens, Maria Almira Correia

Publikováno v: Drug Metabolism and Disposition. 31:360-366

This article is an invited report of a symposium sponsored by the Drug Metabolism Division of the American Society for Pharmacology and Experimental Therapeutics held at Experimental Biology 2002 in New Orleans. The impetus for the symposium was a pe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb065ab27828e701befee1681700689c
https://doi.org/10.1124/dmd.31.4.360

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