Výsledky vyhledávání - "Jeffrey C. Roeser"

p120 Catenin is required for normal tubulogenesis but not epithelial integrity in developing mouse pancreas

Autor: Megan H. Cleveland, Ross W. Bittman, Jeffrey C. Roeser, Elayne Provost, Audrey M. Hendley, Anirban Maitra, Steven D. Leach, Yue J. Wang, Jennifer M. Bailey, Albert B. Reynolds, Danielle Blake

Publikováno v: Developmental Biology. 399:41-53

The intracellular protein p120 catenin aids in maintenance of cell–cell adhesion by regulating E-cadherin stability in epithelial cells. In an effort to understand the biology of p120 catenin in pancreas development, we ablated p120 catenin in mous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b538bcfd19d0b2f49507719dc1934be7
https://doi.org/10.1016/j.ydbio.2014.12.010

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Emerging strategies for cancer immunoprevention

Autor: Florencia McAllister, Steven D. Leach, Jeffrey C. Roeser

Publikováno v: Oncogene. 34(50)

The crucial role of the immune system in the formation and progression of tumors has been widely accepted. On one hand, the surveillance role of the immune system plays an important role in endogenous tumor prevention, but on the other hand, in some

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60e769c711e2581d373b9d02fe42e6de
https://pubmed.ncbi.nlm.nih.gov/26364615

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Re: AR-V7 and Resistance to Enzalutamide and Abiraterone in Prostate Cancer

Publikováno v: European Urology. 68:162-163

Background The androgen-receptor isoform encoded by splice variant 7 lacks the ligand-binding domain, which is the target of enzalutamide and abiraterone, but remains constitutively active as a transcription factor. We hypothesized that detection of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6083455aef228df0ee223bd1aa38bb35
https://doi.org/10.1016/j.eururo.2015.03.054

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Potentiation of the hypoxic ventilatory response by 1 day of hyperoxia in neonatal rats

Autor: Ryan W. Bavis, Eliza S Heerden, Jeffrey C. Roeser, Diane G. Brackett, Kristen M. Young

Publikováno v: Respiratory physiologyneurobiology. 176(1-2)

The O2 sensitivity of the neonatal rat carotid body is increased after one day in moderate hyperoxia (60% O2) (Donnelly et al., Respir. Physiol. Neurobiol. 168: 189–197, 2009). We investigated whether this enhanced peripheral chemosensitivity incre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53202a61d98f87aa6c3fa2879cbed480
https://pubmed.ncbi.nlm.nih.gov/21238615

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Abstract 2910: Androgen receptor splice variant-7 predicts resistance to enzalutamide in patients with castration-resistant prostate cancer

Autor: Brandon Luber, Mario A. Eisenberger, John T. Isaacs, Helen L. Fedor, Hao Wang, Jun Luo, Tamara L. Lotan, Michael A. Carducci, Angelo M. De Marzo, Samuel R. Denmeade, Changxue Lu, Yan Chen, William B. Isaacs, Rosa Nadal, Emmanuel S. Antonarakis, Mary Nakazawa, Channing J. Paller, Jeffrey C. Roeser

Publikováno v: Cancer Research. 74:2910-2910

Background: Androgen receptor splice variant-7 (AR-V7) is a truncated form of the androgen receptor (AR) protein which lacks the ligand-binding domain, the target of enzalutamide, but remains constitutively active as a transcription factor. Following

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::074e68d53e6ce7d6bbbc6db5de548363
https://doi.org/10.1158/1538-7445.am2014-2910

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Abstract 2867: TH17 cells promote early pancreatic tumorigenesis

Autor: Elizabeth M. Jaffee, Christopher J. Nirschl, Rachana H. Lankapalli, Cynthia L. Sears, Jeffrey C. Roeser, Jennifer M. Bailey, Charles G. Drake, Florencia McAllister, Steven D. Leach, Drew M. Pardoll, Jay K. Kolls, Janivette Alsina

Publikováno v: Cancer Research. 73:2867-2867

Chronic pancreatitis increases by 16 fold the risk of developing pancreatic ductal adenocarcinoma (PDAC), one of the deadliest human cancers. Activating Kras mutations have been detected in 30% of early pancreatic intraepithelial neoplasias (PanINs),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b74deb8da45f95ce4ea7196a0ca72026
https://doi.org/10.1158/1538-7445.am2013-2867

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TH17 cells and early pancreatic tumorigenesis

Autor: Jennifer M. Bailey, Jeffrey C. Roeser, Steven D. Leach, Janivette Alsina, Danielle Blake, Charles G. Drake, Elizabeth M. Jaffee, Cynthia L. Sears, Rachana Lankapali, Florencia McAllister, Christopher J. Nirschl, Drew M. Pardoll, Jay K. Kolls

Publikováno v: Journal of Clinical Oncology. 31:144-144

144 Background: Chronic pancreatitis increases the risk of developing pancreatic ductal adenocarcinoma (PDAC), one of the deadliest human cancers. Activating Kras mutations have been detected in 30% of early pancreatic intraepithelial neoplasias (Pan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0a5b1d25faa0cc4f7292d167b595ac2f
https://doi.org/10.1200/jco.2013.31.4_suppl.144

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