Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Jeffrey C. Pelletier"'
Autor:
Kevinn Eddy, Kajal Gupta, Jeffrey C. Pelletier, Allison L. Isola, Christina Marinaro, Maryam Abdur Rasheed, Joseph Campagnolo, Mohamad Naser Eddin, Marco Rossi, Anna Fateeva, Kenneth Reuhl, Raj Shah, Ann K. Robinson, Anna Chaly, Katie B. Freeman, Wenjin Chen, Jesus Diaz, Philip Furmanski, Ann W. Silk, Allen B. Reitz, Andrew Zloza, Suzie Chen
Publikováno v:
Journal of Investigative Dermatology.
Autor:
Manfred Windisch, Jeffrey C. Pelletier, Daniel Martin Watterson, Saktimayee M. Roy, Ottavio Arancio
Publikováno v:
Alzheimer's & Dementia. 16
Autor:
D Martin Watterson, Valerie L Grum-Tokars, Saktimayee M Roy, James P Schavocky, Brinda Desai Bradaric, Adam D Bachstetter, Bin Xing, Edgardo Dimayuga, Faisal Saeed, Hong Zhang, Agnieszka Staniszewski, Jeffrey C Pelletier, George Minasov, Wayne F Anderson, Ottavio Arancio, Linda J Van Eldik
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e66226 (2013)
Serine-threonine protein kinases are critical to CNS function, yet there is a dearth of highly selective, CNS-active kinase inhibitors for in vivo investigations. Further, prevailing assumptions raise concerns about whether single kinase inhibitors c
Externí odkaz:
https://doaj.org/article/b2d92bb12d1e444bacfe050f97863231
Autor:
Katie B. Freeman, Jeffrey C. Pelletier, Richard W. Scott, Damian G. Weaver, Simon D P Baugh, Allen B. Reitz, Sandeep Thanna, Anna L Chaly
Publikováno v:
Bioorganicmedicinal chemistry letters. 33
Invasive fungal infections have become an important healthcare issue due in large part to high mortality rates under standard of care (SOC) therapies creating an urgent need for new and effective anti-fungal agents. We have developed a series of non-
Autor:
Wayne F. Anderson, D. Martin Watterson, Ottavio Arancio, Jeffrey C. Pelletier, Linda J. Van Eldik, George Minasov, Saktimayee M. Roy, Laura Wing Chico
Publikováno v:
Journal of Medicinal Chemistry
[Image: see text] The p38αMAPK is a serine/threonine protein kinase and a key node in the intracellular signaling networks that transduce and amplify stress signals into physiological changes. A preponderance of preclinical data and clinical observa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c728bd759acd158ca318d929952031e
https://europepmc.org/articles/PMC6580366/
https://europepmc.org/articles/PMC6580366/
Autor:
George Minasov, Ottavio Arancio, Linda J. Van Eldik, Wayne F. Anderson, Jeffrey C. Pelletier, D. Martin Watterson, Saktimayee M. Roy, Laura Wing Chico
Publikováno v:
Journal of Medicinal Chemistry. 63:8649-8649
Autor:
Jeffrey C. Pelletier, Faisal Saeed, Valerie Grum-Tokars, Agnieszka Staniszewski, Wayne F. Anderson, George Minasov, Scott J. Webster, D. Martin Watterson, Saktimayee M. Roy, James P. Schavocky, Andrew F. Teich, Adam D. Bachstetter, Ottavio Arancio, Linda J. Van Eldik
Publikováno v:
ACS Chemical Neuroscience
The first kinase inhibitor drug approval in 2001 initiated a remarkable decade of tyrosine kinase inhibitor drugs for oncology indications, but a void exists for serine/threonine protein kinase inhibitor drugs and central nervous system indications.
Publikováno v:
Current Topics in Medicinal Chemistry. 14:2094-2102
We describe here the state of the art of certain aspects concerning potential small molecule therapy directed toward botulism, by inhibition of the zinc-protease containing light chain (LC) of botulinum neurotoxin BoNT/A from the anaerobic bacillus C
Autor:
Garry R. Smith, Deborah Barlow, Allen B. Reitz, Kristin M. Bompiani, Luke L. Lairson, Karen L. Houseknecht, Jeffrey C. Pelletier, Dejan Caglič, Michelle C. Krutein, Tobin J. Dickerson, Galit Benoni
Publikováno v:
Journal of Medicinal Chemistry
Botulinum neurotoxins (BoNT) are the most potent toxins known and a significant bioterrorist threat. Few small molecule compounds have been identified that are active in cell-based or animal models, potentially due to toxin enzyme plasticity. Here we
Autor:
Charles William Mann, Lloyd M. Garrick, Matthew D. Vera, Linda Shanno, Jeffrey C. Pelletier, John F. Rogers, Diane B. Hauze, Jay E. Wrobel, Daniel M. Green, Irene Feingold, Murty Chengalvala, John F. Mehlmann, Joseph T. Lundquist, Joshua E. Cottom
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:2512-2515
Antagonism of the gonadotropin releasing hormone (GnRH) receptor has resulted in positive clinical results in reproductive tissue disorders such as endometriosis and prostate cancer. Following the recent discovery of orally active GnRH antagonists ba