Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Jeffrey C. Martin"'
Autor:
Jeffrey C. Martin, Tatiane da Silva Fernandes, Kanita A. Chaudhry, Masanori Oshi, Scott I. Abrams, Kazuaki Takabe, Spencer R. Rosario, Anna Bianchi-Smiraglia
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Triple-negative breast cancer (TNBC) is one of the most aggressive types of cancer. Despite decades of intense investigation, treatment options remain limited, and rapid recurrence with distant metastases remains a significant challenge. Can
Externí odkaz:
https://doaj.org/article/a7c14905d0a540b290c52c0f37711b58
Autor:
Kanita A. Chaudhry, Justine J. Jacobi, Bryan M. Gillard, Ellen Karasik, Jeffrey C. Martin, Tatiane da Silva Fernandes, Edward Hurley, Maria Laura Feltri, Kristopher M. Attwood, Clare J. Twist, Dominic J. Smiraglia, Mark D. Long, Anna Bianchi-Smiraglia
Publikováno v:
iScience, Vol 26, Iss 11, Pp 108303- (2023)
Summary: Neuroblastoma is the most common extracranial solid tumor in children. MYCN amplification is detected in almost half of high-risk cases and is associated with poorly differentiated tumors, poor patient prognosis and poor response to therapy,
Externí odkaz:
https://doaj.org/article/0f7c74a86b7e44b09089d3f48142cad7
Autor:
Jeffrey C. Martin, Jennie R. Sims, Ajay Gupta, Tamara J. Hagoel, Lingqiu Gao, Miranda L. Lynch, Anna Woloszynska, Thomas Melendy, Jeremy F. Kane, Joseph Kuechle, Joyce E. Ohm
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-10 (2022)
Abstract Ewing sarcoma is the second most common bone malignancy in children and adolescents. In recent years, a large body of evidence has emerged that suggests Ewing tumors harbor large amounts of replication stress (RS). CDC7, also known as DDK (D
Externí odkaz:
https://doaj.org/article/2a7eb0001dd44a14a8ad4db3dab0f299
Publikováno v:
Cancer Res Commun
Ewing sarcoma is an aggressive childhood cancer for which treatment options remain limited and toxic. There is an urgent need for the identification of novel therapeutic strategies. Our group has recently shown that Ewing cells rely on the S-phase ki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::802153af516a255cd757f0b84431cae9
https://doi.org/10.1158/2767-9764.crc-22-0130
https://doi.org/10.1158/2767-9764.crc-22-0130
This figure includes supplementary data to show that CDC7 (DDK) inhibition delays mitotic entry in Ewing cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69c936c4f428bece1ebf3a7786f81691
https://doi.org/10.1158/2767-9764.22544838
https://doi.org/10.1158/2767-9764.22544838
This table provides additional information about the materials used in this study.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f9dababdd33dee1734ef7e4f9571f78
https://doi.org/10.1158/2767-9764.22544829.v1
https://doi.org/10.1158/2767-9764.22544829.v1
Ewing sarcoma is an aggressive childhood cancer for which treatment options remain limited and toxic. There is an urgent need for the identification of novel therapeutic strategies. Our group has recently shown that Ewing cells rely on the S-phase ki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74e4df1016cb9cd236bf7cd4762ef6b1
https://doi.org/10.1158/2767-9764.c.6550758
https://doi.org/10.1158/2767-9764.c.6550758
Autor:
Tamara J. Hagoel, Jeremy Kane, Anna Woloszynska, Thomas Melendy, Joyce E. Ohm, Jeffrey C Martin, Lingui Gao, Joseph Kuechle, Ajay Gupta, Miranda L. Lynch
Ewing sarcoma is the second most common bone malignancy in children and adolescents. Patients with upfront metastatic or recurrent disease have poor outcomes with 5-year survival rates of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50b378d08796f6e6e1915d1cc08fbf5f
https://doi.org/10.1101/2021.11.02.466939
https://doi.org/10.1101/2021.11.02.466939
Autor:
Tamara J, Hagoel, Eduardo, Cortes Gomez, Ajay, Gupta, Clare J, Twist, Rafal, Kozielski, Jeffrey C, Martin, Lingui, Gao, Joseph, Kuechle, Prashant K, Singh, Miranda, Lynch, Lei, Wei, Song, Liu, Jianmin, Wang, Joyce E, Ohm
Publikováno v:
Cold Spring Harbor Molecular Case Studies
Undifferentiated soft tissue sarcomas (UDSTSs) are a group of mesenchymal tumors that remain a diagnostic challenge because of their morphologic heterogeneity and unclear histologic origin (Peters et al., Mod Pathol 28: 575 [2015]). In this case repo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4f0f57aaf15a9fb2751f2e6ff951849f
https://pubmed.ncbi.nlm.nih.gov/34819304
https://pubmed.ncbi.nlm.nih.gov/34819304
Autor:
Anna Woloszynska, Jeffrey C Martin, Miranda L. Lynch, Joyce E. Ohm, Tamara J Hoegel, Thomas Melendy
Publikováno v:
Mol Cancer Res
Ewing sarcoma is an aggressive pediatric tumor of the bone and soft tissue. The current standard of care is radiation and chemotherapy, and patients generally lack targeted therapies. One of the defining molecular features of this tumor type is the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee3bbe365f403b2ba588186a573119df
https://pubmed.ncbi.nlm.nih.gov/33020173
https://pubmed.ncbi.nlm.nih.gov/33020173