Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Jeffrey C. Klein"'
Publikováno v:
Biochemistry. 48:779-785
The initial events of HIV-1 cell infection involve the sequential binding of the viral envelope glycoprotein gp120 to the cellular CD4 receptor and the coreceptor, usually CCR5 or CXCR4. Binding to the coreceptor triggers the chain of events that cul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3ac2e451aaf59e4c4f8a7b13e015781
https://doi.org/10.1021/bi8021476
https://doi.org/10.1021/bi8021476
Autor:
Vanessa Pirrone, Shendra R. Miller, Simon Cocklin, Sabine Baxter, Ferit Tuzer, Irwin Chaiken, Judith M. LaLonde, M. Umashankara, Jeffrey C. Klein, Navneet Jawanda, Fred C. Krebs, Arne Schön, Amos B. Smith, Joseph Sodroski, Ernesto Freire, Navid Madani, Hosahudya N. Gopi, Isaac Zentner
Publikováno v:
Journal of Medicinal Chemistry. 51:2638-2647
Structure-activity correlations were investigated for substituted peptide conjugates that function as dual receptor site antagonists of HIV-1 gp120. A series of peptide conjugates were constructed via click reaction of both aryl and alkyl acetylenes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f3bd9ceed55edf3bccdc7ccc21887b3
https://doi.org/10.1021/jm070814r
https://doi.org/10.1021/jm070814r
Autor:
Arne Schön, Amos B. Smith, Xinzhen Yang, Joseph Sodroski, Jeffrey C. Klein, Amy M. Hubicki, Ernesto Freire, Danny Ng, Navid Madani
Publikováno v:
Biochemistry. 45:10973-10980
The entry of human immunodeficiency virus (HIV-1) into target cells is mediated by the gp120 exterior envelope glycoprotein and the gp41 transmembrane envelope glycoprotein, which assemble into trimers on the virion surface (1, 2). Upon engaging the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e20ca3b0245c01c1262b4bd8d7c4151
https://doi.org/10.1021/bi061193r
https://doi.org/10.1021/bi061193r
Autor:
Jason J. Chruma, Arne Schön, Liping Wang, Amos B. Smith, Joseph Sodroski, Jason M. Cox, Ernesto Freire, Navid Madani, Irwin Chaiken, Alyssa C. Biorn, Ngoc Phan, Simon Cocklin, Jeffrey C. Klein, Zhihai Si
Publikováno v:
Proceedings of the National Academy of Sciences. 101:5036-5041
When interacting with the CD4 receptor, the HIV gp120 envelope glycoprotein undergoes conformational changes that allow binding to the chemokine receptor. Receptor binding is proposed to lead to conformational changes in the gp41 transmembrane envelo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c2611b4d8538bdf658dbb6507fb69b3
https://doi.org/10.1073/pnas.0307953101
https://doi.org/10.1073/pnas.0307953101
Publikováno v:
Pediatric Transplantation. 7:80-82
The vascular supply of the liver and gallbladder is characterized by a striking degree of polymorphism. The occurrence of variants that differ from the usual pattern is both surprisingly common and unpredictable. Knowledge of this variable anatomy is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14838afd6c0d7ff301c6d17947bd6a51
https://doi.org/10.1034/j.1399-3046.2003.02046.x
https://doi.org/10.1034/j.1399-3046.2003.02046.x
Autor:
Stephanie A. Leavitt, Uma V. Manjappara, Arne Schön, Jeffrey C. Klein, Ernesto Freire, Irwin Chaiken
Publikováno v:
Current proteinpeptide science. 5(1)
During the course of infection, a subset of HIV-1 proteins interacts with multiple cellular partners, sometimes in a hierarchical or sequential way. These proteins include those associated with the initial infection event, with the preparation of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85577b0093146518f60b423f9fac4e4c
https://pubmed.ncbi.nlm.nih.gov/14965316
https://pubmed.ncbi.nlm.nih.gov/14965316
Autor:
Hosahudya Gopi, M. Umashankara, Vanessa Pirrone, Judith LaLonde, Navid Madani, Ferit Tuzer, Sabine Baxter, Isaac Zentner, Simon Cocklin, Navneet Jawanda, Shendra R. Miller, Arne Schön, Jeffrey C. Klein, Ernesto Freire, Fred C. Krebs, Amos B. Smith, Joseph Sodroski, Irwin Chaiken
Publikováno v:
Journal of Medicinal Chemistry; Apr2008, Vol. 51 Issue 9, p2638-2647, 10p