Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Jeffrey C. Hoyt"'
Autor:
Jenny Pattengill, Jeffrey C. Hoyt, Alp Umar, John M. Hayden, Richard A. Robbins, Grigory Horonenko, Clement Singarajah
Publikováno v:
Chest. 132:58-63
Rationale: The diagnosis of ventilator-associated pneumonia (VAP) can be difficult. Soluble triggering receptor expressed on myeloid cell-1 (sTREM-1) has been reported to be elevated in BAL fluid from patients with VAP. Objectives: To evaluate the ut
Autor:
Richard A. Robbins, Muhammad Kashif Raza, John M Hayden, Janelle G. Ballering, Jeffrey C. Hoyt
Publikováno v:
Experimental Lung Research. 32:15-26
Certain antibiotics possess anti-inflammatory properties and could potentially be used to treat inflammatory lung diseases associated with an influx of monocytes such as panbronchiolitis, asthma, cystic fibrosis, and bronchitis. Doxycycline is report
Publikováno v:
The Journal of Immunology. 176:567-572
Many effective therapeutic agents exhibit effects that are different from their intended primary mode of action. Antibiotics such as doxycycline and erythromycin A are no exception. They also display anti-inflammatory activity. Using LA4 murine lung
Autor:
Jeffrey C. Hoyt, Dan K. Nelson, Richard A. Robbins, Sekiya Koyama, Etsuro Sato, Michael P. Habib, Jun Amano, Hiroki Numanami, Masayuki Haniuda, Jon L. Freels
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 29:613-619
Smoking is associated with lung inflammation and a protease-antiprotease imbalance. We previously reported that cigarette smoke extract (CSE) stimulates human lung fibroblasts to release chemotactic cytokines. We hypothesized that serine protease inh
Autor:
Michael P. Habib, Richard A. Robbins, Jeffrey C. Hoyt, Masayuki Haniuda, Dan K. Nelson, Jon L. Freels, Jun Amano, Hiroki Numanami, Sekiya Koyama
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 29:239-244
Peroxynitrite, formed by nitric oxide and superoxide, has been shown to nitrate and reduce the function of proinflammatory proteins such as interleukin (IL)-8, monocyte chemoattractant protein-1, and eotaxin, but in contrast, to enhance the function
Publikováno v:
Molecular Microbiology. 46:505-517
Summary Streptomyces viridifaciens MG456-hF10 produces the antibiotic valanimycin, a naturally occurring azoxy compound. Valanimycin is known to be derived from valine and serine with the intermediacy of isobutylamine and isobutylhydroxylamine, but l
Autor:
Jeffrey C. Hoyt, Richard A. Robbins
Publikováno v:
FEMS Microbiology Letters. 205:1-7
Many clinically effective therapeutic agents can exhibit localized and systemic effects that are manifestly different from their intended primary pharmacological mode of action. Macrolide antibiotics such as erythromycin and its derivatives are no ex
Autor:
Veronica K Robinson, Etsuro Sato, Jeffrey C. Hoyt, Richard A. Robbins, Sharon L. Camhi, Dan K. Nelson
Publikováno v:
Free Radical Biology and Medicine. 30:986-991
Peroxynitrite, formed by nitric oxide (NO) and superoxide, can alter protein function by nitrating amino acids such as tyrosine, cysteine, trytophan, or methionine. Inducible nitric oxide synthase (Type 2 NOS or iNOS) converts arginine to citrulline,
Publikováno v:
Experimental Lung Research. 27:173-183
Eotaxin, a potent eosinophil-specific chemotactic factor, is increased in the lower respiratory tract of asthma patients. Recently, lung fibroblasts have been reported to produce eotaxin and their activation can be modulated by inflammatory cytokines
Publikováno v:
Immunopharmacology. 48:217-221