Zobrazeno 1 - 10
of 202
pro vyhledávání: '"Jeffrey C. Fink"'
Autor:
Melissa Metry, Samuel A. Krug, Vijaya Kumari Karra, Maureen A. Kane, Jeffrey C. Fink, Yan Shu, Hongbing Wang, James E. Polli
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 10, Pp 2468-2478 (2022)
Abstract Metformin has been shown to repress transcription of the bile salt export pump (BSEP) in human primary hepatocytes. The primary objective of this study was to assess the effect of oral metformin on the human pharmacokinetics (PKs) of two BSE
Externí odkaz:
https://doaj.org/article/828740e9b66c4c97beeabb95fd2b9b82
Autor:
Jeffrey C. Fink, Rebecca M. Maguire, Thomas Blakeman, Laurie A. Tomlinson, Charles Tomson, Lee-Ann Wagner, Min Zhan
Publikováno v:
Kidney Medicine, Vol 4, Iss 9, Pp 100527- (2022)
Rationale & Objective: Some drugs prescribed for chronic kidney disease (CKD) may become hazardous on sick days with volume depletion by increasing the risk of acute kidney injury (AKI) and kidney function loss; however, the risks and benefits of the
Externí odkaz:
https://doaj.org/article/41c7baecb1d64757bde920875ec2a386
Autor:
Sarah J. Schrauben, Jesse Y. Hsu, Julie Wright Nunes, Michael J. Fischer, Anand Srivastava, Jing Chen, Jeanne Charleston, Susan Steigerwalt, Thida C. Tan, Jeffrey C. Fink, Ana C. Ricardo, James P. Lash, Myles Wolf, Harold I. Feldman, Amanda H. Anderson, Lawrence J. Appel, Alan S. Go, Jian He, John W. Kusek, Panduranga S. Rao, Mahboob Rahman, Raymond R. Townsend
Publikováno v:
Kidney International Reports, Vol 4, Iss 1, Pp 80-93 (2019)
Introduction: A cornerstone of kidney disease management is participation in guideline-recommended health behaviors. However, the relationship of these health behaviors with outcomes, and the identification of barriers to health behavior engagement,
Externí odkaz:
https://doaj.org/article/38bd67beab2c44ada3e1d4323df9ed75
Autor:
Jessica Cornell, Andrew Conchas, Xin‐Qun Wang, Jeffrey C. Fink, Hegang Chen, Maureen A. Kane, Nageswara Pilli, Nassima Ait‐Daoud, David A. Gorelick, Ming D. Li, Bankole A. Johnson, Chamindi Seneviratne
Publikováno v:
Alcoholism: Clinical and Experimental Research. 46:1888-1899
The serotonin transporter (SERT) mRNA was previously reported to be a quantitative and pathophysiology-based biomarker of heavy drinking in 5HTTLPR:LL genotype-carriers treated with ondansetron. Here, we validated the potential use of SERT mRNA for q
Autor:
Melissa Metry, Samuel A. Krug, Vijaya Kumari Karra, Maureen A. Kane, Jeffrey C. Fink, Yan Shu, Hongbing Wang, James E. Polli
Publikováno v:
Clinical and Translational Science. 15:2468-2478
Metformin has been shown to repress transcription of the bile salt export pump (BSEP) in human primary hepatocytes. The primary objective of this study was to assess the effect of oral metformin on the human pharmacokinetics (PKs) of two BSEP probe s
Autor:
Melissa Metry, Samuel A. Krug, Vijaya Kumari Karra, Sean Ekins, Stephen W. Hoag, Maureen A. Kane, Jeffrey C. Fink, James E. Polli
Publikováno v:
Pharmaceutical Research. 39:1881-1890
Publikováno v:
User Modeling and User-Adapted Interaction. 31:979-1025
Interaction with patient-facing medical devices requires integrated performance of both physical and cognitive tasks that are highly dependent on many user characteristics. Quantifying product use variability early in the design process is useful for
Publikováno v:
Kidney360
Background The comparative utility of performance-based functional assessments in predicting adverse outcomes in CKD is unknown. To examine their relative utility, we examined three performance-based functional assessments in an observational cohort
Autor:
Lawrence J. Appel, Pandu Rao, James P. Lash, Debbie L. Cohen, Sarah J. Schrauben, Clarissa J. Diamantidis, Sylvia E. Rosas, Chi-yuan Hsu, Aditya Surapaneni, Julia J. Scialla, Cric Study Investigators, James H. Sondheimer, Sankar D. Navaneethan, Jesse Y. Hsu, Jeffrey C. Fink, Morgan E. Grams, Dawei Xie, Alfred K. Cheung, Bernard G. Jaar, Harold I. Feldman
Publikováno v:
Nephrology Dialysis Transplantation. 36:1685-1693
Background Patients with chronic kidney disease (CKD) face risks of not only end-stage kidney disease (ESKD), cardiovascular disease (CVD) and death, but also decline in kidney function, quality of life (QOL) and mental and physical well-being. This
Autor:
Lee-Ann Wagner, Jeffrey C. Fink
Publikováno v:
Clin J Am Soc Nephrol
BACKGROUND AND OBJECTIVES: Patients with CKD are at risk for adverse drug reactions, but effective community-based preventive programs remain elusive. In this study, we compared the effectiveness of two digital applications designed to improve outpat