Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Jeffrey C. Boehm"'
Autor:
Shuping Dong, Yolanda Sanchez, Tindy Li, Claudia E. Murar, Anthony J. Wilson, Brent W. Mccleland, Hongwei Qi, Patricia L. Podolin, Marc Galop, Christopher J. Moody, Hongxing Yan, John Yonchuk, Roderick S. Davis, Alan P. Graves, Catherine Booth-Genthe, Joseph P. Foley, Jen-Pyng Kou, Jeffrey K. Kerns, Brian Bolognese, James F. Callahan, Mary Mentzer, Lawrence Wolfe, Jeffrey C. Boehm, Robin Carr
Publikováno v:
Bioorganic & Medicinal Chemistry. 27:579-588
The antioxidant natural product sulforaphane (SFN) is an oil with poor aqueous and thermal stability. Recent work with SFN has sought to optimize methods of formulation for oral and topical administration. Herein we report the design of new analogs o
Autor:
Xichen Lin, Michael E. Muratore, Huijie Li, Ami S. Lakdawala, Jakob Busch-Petersen, Ruth R. Osborn, David D. Miller, Jeffrey K. Kerns, Rick P. C. Cousins, Ian Robert Baldwin, Paul Bamborough, John Yonchuk, Ann M. Bullion, Lin Guoliang, Jeffrey C. Boehm, Wei Fu, John A. Christopher, Edward F. Webb, Roderick S. Davis, William L. Rumsey, Rita Field, Jeremy John Payne, Hong Nie
Publikováno v:
ACS Medicinal Chemistry Letters. 9:1164-1169
[Image: see text] IκB kinase β (IKKβ or IKK2) is a key regulator of nuclear factor kappa B (NF-κB) and has received attention as a therapeutic target. Herein we report on the optimization of a series of 3,5-disubstituted-indole-7-carboxamides for
Autor:
James F. Callahan, Hongxing Yan, Roderick S. Davis, Venkatraman Junnotula, Catherine Booth-Genthe, Hermes Licea Perez, Yolanda Sanchez, Hong Nie, Dana Knecht, Jeffrey C. Boehm
Publikováno v:
The Analyst. 139:1902-1912
Activation of the Nrf2 stress pathway is known to play an important role in the defense mechanism against electrophilic and oxidative damage to biological macromolecules (DNA, lipids, and proteins). Chemical inducers of Nrf2 such as sulforaphane, dim
Autor:
William D. Kingsbury, Jeffrey C. Boehm
Publikováno v:
International Journal of Peptide and Protein Research. 27:659-665
The synthesis of peptides useful for the investigation of microbial peptide transport is reported. These peptides, L-alanyl-L-2-thiophenylglycine (Ala-alpha-TPG), L-alanyl-L-2-thiophenylglycyl-L-alanine (Ala-alpha-TPG-Ala) and L-alanyl-L-alanyl-L-2-t
Autor:
Zehong Wan, Jerry L. Adams, Shouki Kassis, Baoguang Zhao, John C. Lee, Jeffrey C. Boehm, Michael J. Bower
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:1191-1194
The design, synthesis and SAR of a series of 2,6,9-trisubstituted purine inhibitors of p38alpha kinase is reported. Synthetic routes were devised to allow for array synthesis in which all three points of diversity could be facilely explored. The bind
Autor:
Stephen R. Johnson, Jeffrey C. Boehm, Michael J. Bower, Jerry L. Adams, Shouki Kassis, Timothy Francis Gallagher
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:1123-1126
As a continuation of our work with 1,4,5 substituted imidazole inhibitors of p38α, we report a series of 1-(4-piperidinyl)-4-(4-fluorophenyl)-5-(2-phenoxy-4-pyrimidinyl) imidazoles related to 7 . The compounds have IC 50 's for inhibition of p38α r
Autor:
Edward F. Webb, Alison M. Badger, Simon M. Blake, S.J. Hoffman, Jerry L. Adams, Jeffrey C. Boehm, David J. Rieman, Maxine Gowen, Barbara A. Swift, Don E. Griswold, Rasesh Kapadia, John C. Lee, George B. Stroup
Publikováno v:
Arthritis & Rheumatism. 43:175-183
Objective To evaluate the effects of SB 242235, a potent and selective inhibitor of p38 mitogen-activated protein (MAP) kinase, on joint integrity in rats with adjuvant-induced arthritis (AIA). Methods Male Lewis rats with AIA were orally treated eit
Autor:
Jerry L. Adams, Jeffrey C. Boehm
Publikováno v:
Expert Opinion on Therapeutic Patents. 10:25-37
In the short time since the 1994 report that the molecular target for the 4-aryl-5-pyridin-4-yl imidazole class of cytokine suppressive anti-inflammatory agents (exemplified by SB-203580) was the human homologue of the stress-induced kinase p38, ther
Autor:
Jerry L. Adams, Don E. Griswold, Ralph Hall, Margaret E. Sorenson, Timothy Francis Gallagher, Edward F. Webb, Shouki Kassis, John C. Lee, Andrew Ayrton, Peter D. Gorycki, Jeffrey C. Boehm
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 8:3111-3116
Pyrimidine analogs of the pyrimidinylimidazole class of CSBP/p38 kinase inhibitors were prepared in an effort to reduce the potent inhibition of hepatic cytochrome P450 observed for the pyridinyl compounds. The substitution of pyrimidin-4-yl, 2-metho
Autor:
Jeremy Bradbeer, Margaret E. Sorenson, Jerry L. Adams, Marie Chabot-Fletcher, John J. Breton, Donald E. Griswold, Timothy Francis Gallagher, L. M. Hillegass, Alison M. Badger, Ravi Shanker Garigipati, Juanita M. Smietana, Peter L. Sheldrake, John C. Lee, Jeffrey T. Laydon, Jeffrey C. Boehm
Publikováno v:
Journal of Medicinal Chemistry. 39:3929-3937
A series of 1-alkyl- or -aryl-4-aryl-5-pyridinylimidazoles (A) were prepared and tested for their ability to bind to a recently discovered protein kinase termed CSBP and to inhibit lipopolysaccharide (LPS)-stimulated TNF production in mice. The kinas