Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Jeffrey C Wolchok"'
Autor:
Kevin Roberts, John Taehwan Kim, Tai Huynh, Jacob Schluns, Grady Dunlap, Jamie Hestekin, Jeffrey C Wolchok
Publikováno v:
BMC Musculoskeletal Disorders, Vol 24, Iss 1, Pp 1-13 (2023)
Abstract Volumetric muscle loss overwhelms skeletal muscle’s ordinarily capable regenerative machinery, resulting in severe functional deficits that have defied clinical repair strategies. In this manuscript we pair the early in vivo functional res
Externí odkaz:
https://doaj.org/article/dfd003caf53f46a89f8df603f087cc79
Autor:
John T. Kim, Kevin Roberts, Grady Dunlap, Richard Perry, Tyrone Washington, Jeffrey C. Wolchok
Publikováno v:
Journal of Tissue Engineering and Regenerative Medicine. 16:367-379
Aging hinders the effectiveness of regenerative medicine strategies targeting the repair of volumetric muscle loss (VML) injury. Anabolic steroids have been shown to improve several factors which contribute to the age-related decline in muscle's rege
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f879dcf327638f71b5669a0b6e27a81a
https://doi.org/10.1002/term.3286
https://doi.org/10.1002/term.3286
In this study we examined the potential of muscle derived extracellular matrix (ECM) gel prepared from skeletal muscle as a treatment strategy for acute and chronic degenerative atrophy. We conducted experiments to evaluate the gel’s effectiveness
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b77b187f950eb4b0fc5da209cc035d88
https://doi.org/10.21203/rs.3.rs-2379543/v1
https://doi.org/10.21203/rs.3.rs-2379543/v1
Autor:
Celeste S. Dunn, Laís A. Ferreira, Sara M. Venier, Syed F. Ali, Jeffrey C. Wolchok, Kartik Balachandran
Publikováno v:
Neurotrauma reports. 3(1)
The pathological effects of repeated traumatic brain injuries (TBIs) are largely unknown. To gain a detailed understanding of the cortical tissue acute biological response after one or two TBIs, we utilized RNA-sequencing and protein mass spectrometr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b12c83725ac5dd2078d145548781cbfc
https://pubmed.ncbi.nlm.nih.gov/35919509
https://pubmed.ncbi.nlm.nih.gov/35919509
Autor:
Nicholas P. Greene, Jeffrey C. Wolchok, Tyrone A. Washington, Wesley S. Haynie, John T. Kim, Richard A. Perry
Publikováno v:
Exp Physiol
New findings What is the central question of this study? Following large traumatic loss of muscle tissue (volumetric muscle loss; VML), permanent functional and cosmetic deficits present themselves and regenerative therapies alone have not been able
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9120d4c6ac8b6021deacd4b43eb8badd
https://doi.org/10.1113/ep089207
https://doi.org/10.1113/ep089207
Publikováno v:
J Shoulder Elbow Surg
Introduction Extracellular matrix (ECM) gels have shown efficacy for the treatment of damaged tissues, most notably cardiac muscle. We hypothesized that the ECM gel prepared from skeletal muscle could be used as a treatment strategy for fatty shoulde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::400d43f01b666c7e9e69119c989dceb5
https://doi.org/10.1016/j.jse.2020.03.038
https://doi.org/10.1016/j.jse.2020.03.038
Autor:
Lemuel A. Brown, Jeffrey C. Wolchok, Ben Kasukonis, Kevin Roberts, Grady Dunlap, TA Washington, John Kim
Publikováno v:
Acta Biomater
A key event in the etiology of volumetric muscle loss (VML) injury is the bulk loss of structural cues provided by the underlying extracellular matrix (ECM). To re-establish the lost cues, there is broad consensus within the literature supporting the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2381bcfa970b713d358b42b4db0df777
https://doi.org/10.1016/j.actbio.2020.01.024
https://doi.org/10.1016/j.actbio.2020.01.024
Autor:
John T. Kim, Tyrone A. Washington, Jeffrey C. Wolchok, Richard A. Perry, Benjamin M. Kasukonis, Grady Dunlap
Publikováno v:
Tissue Eng Part A
In this study, the influence of age on effectiveness of regenerative repair for the treatment of volumetric muscle loss (VML) injury was explored. Tibialis anterior (TA) VML injuries were repaired in both 3- and 18-month-old animal models (Fischer 34
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bc6b466431e0fe2490e4106fd150770
https://doi.org/10.1089/ten.tea.2019.0034
https://doi.org/10.1089/ten.tea.2019.0034
Autor:
Lemuel A. Brown, Jeffrey C. Wolchok, Megan E. Rosa-Caldwell, Jacob L. Brown, Richard A. Perry, Wesley S. Haynie, Tyrone A. Washington, Nicholas P. Greene, David E. Lee
Publikováno v:
Mechanisms of ageing and development. 194
The purpose of this study was to determine whether sarcopenic obesity accelerates impairments in muscle maintenance through the investigation of cell cycle progression and myogenic, inflammatory, catabolic and protein synthetic signaling in mouse gas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad615b2055f43bbbf3c8f6d7eb8188b6
https://pubmed.ncbi.nlm.nih.gov/33249192
https://pubmed.ncbi.nlm.nih.gov/33249192
Publikováno v:
Journal of Visualized Experiments.
Engineered scaffolds derived from extracellular matrix (ECM) have driven significant interest in medicine for their potential in expediting wound closure and healing. Extraction of extracellular matrix from fibrogenic cell cultures in vitro has poten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1c96ef41cb4d23e18be7335375436db
https://doi.org/10.3791/58791
https://doi.org/10.3791/58791