Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Jeffrey C Raum"'
Autor:
Xiaodun Yang, Jeffrey C. Raum, Junil Kim, Reynold Yu, Juxiang Yang, Gabriella Rice, Changhong Li, Kyoung-Jae Won, Diana E. Stanescu, Doris A. Stoffers
Publikováno v:
Development
Yang, X, Raum, J C, Kim, J, Yu, R, Yang, J, Rice, G, Li, C, Won, K-J, Stanescu, D E & Stoffers, D A 2022, ' A PDX1 cistrome and single-cell transcriptome resource of the developing pancreas ', Development, vol. 149, no. 13, 200432 . https://doi.org/10.1242/dev.200432
Yang, X, Raum, J C, Kim, J, Yu, R, Yang, J, Rice, G, Li, C, Won, K-J, Stanescu, D E & Stoffers, D A 2022, ' A PDX1 cistrome and single-cell transcriptome resource of the developing pancreas ', Development, vol. 149, no. 13, 200432 . https://doi.org/10.1242/dev.200432
Pancreatic and duodenal homeobox 1 (PDX1) is crucial for pancreas organogenesis, yet the dynamic changes in PDX1 binding in human or mouse developing pancreas have not been examined. To address this knowledge gap, we performed PDX1 ChIP-seq and singl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68d3430aef1654d66326c0d87d2521be
https://europepmc.org/articles/PMC9340549/
https://europepmc.org/articles/PMC9340549/
Publikováno v:
Aesthetic Surgery Journal. 40:108-117
Background The efficacy of adipose-derived stem cells (ASCs) to improve wound healing has been extensively investigated. Unfortunately, no consistent reports have described significant improvements in healing time or outcomes in large-scale clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16f262f7b3465956a7dc7ba551f1093b
https://doi.org/10.1093/asj/sjz071
https://doi.org/10.1093/asj/sjz071
Autor:
Reynold Yu, Jeffrey C. Raum, Juxiang Yang, Kyoung-Jae Won, Xiaodun Yang, Gabriella Rice, Doris A. Stoffers, Junil Kim, Changhong Li, Diana E. Stanescu
SummaryPancreatic and duodenal homeobox 1 (PDX1)is crucial for pancreas organogenesis, yet the dynamic changes in PDX1 targets in mouse or human pancreas development have not been examined. We integrated the PDX1 cistrome with cell lineage-specific g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbf9c2a2c092c8dfece402125ac636c0
https://doi.org/10.1101/2021.02.28.433241
https://doi.org/10.1101/2021.02.28.433241
Autor:
Jorge Ferrer, Min Guo, Frederick H. Thompson, Chad S. Hunter, Miguel Angel Maestro, Roland Stein, Jeffrey C. Raum
Publikováno v:
Molecular Endocrinology. 25:339-347
The expression pattern of genes important for pancreatic islet cell function requires the actions of cell-enriched transcription factors. Musculoaponeurotic fibrosarcoma homolog A (MafA) is a β-cell-specific transcriptional activator critical to adu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1726f4bbc89bb726ad2987ab3700d5a6
https://doi.org/10.1210/me.2010-0362
https://doi.org/10.1210/me.2010-0362
Autor:
Diva D. De León, Jeffrey C. Raum, Ali Naji, Doris A. Stoffers, Scott A. Soleimanpour, David N. Groff, Jake A. Kushner, Michael F. Crutchlow, Alana M. Ferrari, Matthew M. Rankin, Chengyang Liu
Publikováno v:
Journal of Biological Chemistry. 285:40050-40059
The calcium-regulated phosphatase calcineurin intersects with both calcium and cAMP-mediated signaling pathways in the pancreatic β-cell. Pharmacologic calcineurin inhibition, necessary to prevent rejection in the setting of organ transplantation, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3a6916339c8c633a10eb54dc93e857b
https://doi.org/10.1074/jbc.m110.154955
https://doi.org/10.1074/jbc.m110.154955
Autor:
Chad S. Hunter, Eva Henderson, Roland Stein, Min Guo, Takeshi Ogihara, Isabella Artner, Lori Sussel, Raghavendra G. Mirmira, Beatriz Sosa-Pineda, Jeffrey C. Raum, Lynda Elghazi
Publikováno v:
Molecular and Cellular Biology. 30:4234-4244
MafA is a key transcriptional activator of islet beta cells, and its exclusive expression within beta cells of the developing and adult pancreas is distinct among pancreatic regulators. Region 3 (base pairs -8118 to -7750 relative to the transcriptio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c29ccc7203507f32d35c1d23bbc36d7f
https://doi.org/10.1128/mcb.01396-09
https://doi.org/10.1128/mcb.01396-09
Autor:
Jeffrey C. Raum, Alistair N. Garratt, Doris A. Stoffers, Chunhua Dai, Scott A. Soleimanpour, Nathalie Coré, Alvin C. Powers, Laurent Fasano, David N. Groff
Publikováno v:
Diabetes
Diabetes, American Diabetes Association, 2015, 64 (8), pp.2905-14. ⟨10.2337/db14-1443⟩
Diabetes, 2015, 64 (8), pp.2905-14. ⟨10.2337/db14-1443⟩
Diabetes, American Diabetes Association, 2015, 64 (8), pp.2905-14. ⟨10.2337/db14-1443⟩
Diabetes, 2015, 64 (8), pp.2905-14. ⟨10.2337/db14-1443⟩
International audience; The homeodomain transcription factor Pdx1 controls pancreas organogenesis, specification of endocrine pancreas progenitors, and the postnatal growth and function of pancreatic β-cells. Pdx1 expression in human-derived stem ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9b3633dabce81e5faca301cc0815869
https://hal.archives-ouvertes.fr/hal-01428832
https://hal.archives-ouvertes.fr/hal-01428832
Autor:
Rajan, Jain, Deqiang, Li, Mudit, Gupta, Lauren J, Manderfield, Jamie L, Ifkovits, Qiaohong, Wang, Feiyan, Liu, Ying, Liu, Andrey, Poleshko, Arun, Padmanabhan, Jeffrey C, Raum, Li, Li, Edward E, Morrisey, Min Min, Lu, Kyoung-Jae, Won, Jonathan A, Epstein
Publikováno v:
Science (New York, N.Y.). 348(6242)
Cardiac progenitor cells are multipotent and give rise to cardiac endothelium, smooth muscle, and cardiomyocytes. Here, we define and characterize the cardiomyoblast intermediate that is committed to the cardiomyocyte fate, and we characterize the ni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::96ac111a959b108db4f03aa7c4e2d3bd
https://pubmed.ncbi.nlm.nih.gov/26321185
https://pubmed.ncbi.nlm.nih.gov/26321185
Autor:
Feiyan Liu, Jonathan A. Epstein, Deqiang Li, Li Li, Arun Padmanabhan, Jamie L. Ifkovits, Mudit Gupta, Jeffrey C. Raum, Edward E. Morrisey, Qiaohong Wang, Min Min Lu, Ying Liu, Andrey Poleshko, Lauren J. Manderfield, Kyoung-Jae Won, Rajan Jain
Publikováno v:
Science. 348
Making cardiomyocytes In the heart, multiple cell types work together. Cardiac progenitor cells give rise to cardiomyocyte, endothelial, or smooth muscle lineages. However, the identity of a marker specific to cardiomyocyte formation has been elusive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab64e858d062be123047c1c3fabf9edd
https://doi.org/10.1126/science.aaa6071
https://doi.org/10.1126/science.aaa6071
Diabetes Susceptibility Genes Pdx1 and Clec16a Function in a Pathway Regulating Mitophagy in β-Cells
Autor:
Alana M. Ferrari, Juxiang Yang, David N. Groff, Doris A. Stoffers, Jeffrey C. Raum, Scott A. Soleimanpour, Brett A. Kaufman
Publikováno v:
Diabetes
Mitophagy is a critical regulator of mitochondrial quality control and is necessary for elimination of dysfunctional mitochondria to maintain cellular respiration. Here, we report that the homeodomain transcription factor Pdx1, a gene associated with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62fd89c4c0c1ff68c674bfde19dc1333
https://pubmed.ncbi.nlm.nih.gov/26085571
https://pubmed.ncbi.nlm.nih.gov/26085571