Unsupervised Machine Learning on Motion Capture Data Uncovers Movement Strategies in Low Back Pain

Autor: Anastasia V. Keller, Abel Torres-Espin, Thomas A. Peterson, Jacqueline Booker, Conor O’Neill, Jeffrey C Lotz, Jeannie F Bailey, Adam R. Ferguson, Robert P. Matthew

Publikováno v: Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)

Chronic low back pain (LBP) is a leading cause of disability and opioid prescriptions worldwide, representing a significant medical and socioeconomic problem. Clinical heterogeneity of LBP limits accurate diagnosis and precise treatment planning, cul

Externí odkaz: https://doaj.org/article/6c0ff3132589493b835a5e400b50a73d

Role of matrix metalloproteinase 13 in both endochondral and intramembranous ossification during skeletal regeneration.

Autor: Danielle J Behonick, Zhiqing Xing, Shirley Lieu, Jenni M Buckley, Jeffrey C Lotz, Ralph S Marcucio, Zena Werb, Theodore Miclau, Céline Colnot

Publikováno v: PLoS ONE, Vol 2, Iss 11, p e1150 (2007)

Extracellular matrix (ECM) remodeling is important during bone development and repair. Because matrix metalloproteinase 13 (MMP13, collagenase-3) plays a role in long bone development, we have examined its role during adult skeletal repair. In this s

Externí odkaz: https://doaj.org/article/1f84ec6326834e2e943c5a9110a0b3b3

Intradiscal treatment of the cartilage endplate for improving solute transport and disc nutrition

Autor: Mohamed Habib, Shayan Hussien, Oju Jeon, Jeffrey C. Lotz, Peter I-Kung Wu, Eben Alsberg, Aaron J. Fields

Publikováno v: Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)

Poor nutrient transport through the cartilage endplate (CEP) is a key factor in the etiology of intervertebral disc degeneration and may hinder the efficacy of biologic strategies for disc regeneration. Yet, there are currently no treatments for impr

Externí odkaz: https://doaj.org/article/111c24307dc7416b92dc1a817bd4bd48

ISSLS Prize in Bioengineering Science 2023: Age- and sex-related differences in lumbar intervertebral disc degeneration between patients with chronic low back pain and asymptomatic controls

Autor: Noah B. Bonnheim, Ann A. Lazar, Anika Kumar, Zehra Akkaya, Jiamin Zhou, Xiaojie Guo, Conor O’Neill, Thomas M. Link, Jeffrey C. Lotz, Roland Krug, Aaron J. Fields

Publikováno v: European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, vol 32, iss 5

Purpose Clinical management of disc degeneration in patients with chronic low back pain (cLBP) is hampered by the challenge of distinguishing pathologic changes relating to pain from physiologic changes related to aging. The goal of this study was to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48d632c74de2973ef33566bdca5b0a7d
https://escholarship.org/uc/item/7n44264w

Compensatory biomechanics and spinal loading during dynamic maneuvers in patients with chronic low back pain

Autor: Priya Nyayapati, Jacqueline Booker, Peter I-Kung Wu, Alekos Theologis, Lucas Dziesinski, Conor O’Neill, Patricia Zheng, Jeffrey C. Lotz, Robert P. Matthew, Jeannie F. Bailey

Publikováno v: European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, vol 31, iss 7

Purpose This study explores the biomechanics underlying the sit-to-stand (STS) functional maneuver in chronic LBP patients to understand how different spinal disorders and levels of pain severity relate to unique compensatory biomechanical behaviors.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b3ffd9e311c58d91b7f9d86cd34ff4e
https://doi.org/10.1007/s00586-022-07253-4