Výsledky vyhledávání - "Jeffrey C Francis"

Akademický článek

Pten Regulates Epithelial Cytodifferentiation during Prostate Development.

Autor: Isabel B Lokody, Jeffrey C Francis, Jennifer R Gardiner, Janine T Erler, Amanda Swain

Publikováno v: PLoS ONE, Vol 10, Iss 6, p e0129470 (2015)

Gene expression and functional studies have indicated that the molecular programmes involved in prostate development are also active in prostate cancer. PTEN has been implicated in human prostate cancer and is frequently mutated in this disease. Here

Externí odkaz: https://doaj.org/article/965f1e7366f14f7bb43f42183a8e6726

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Akademický článek

β-catenin is required for prostate development and cooperates with Pten loss to drive invasive carcinoma.

Autor: Jeffrey C Francis, Martin K Thomsen, Makoto M Taketo, Amanda Swain

Publikováno v: PLoS Genetics, Vol 9, Iss 1, p e1003180 (2013)

Prostate cancer is a major cause of male death in the Western world, but few frequent genetic alterations that drive prostate cancer initiation and progression have been identified. β-Catenin is essential for many developmental processes and has bee

Externí odkaz: https://doaj.org/article/00e08ac2daed41469c8afefeefb4e158

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Akademický článek

Brca2 and Trp53 deficiency cooperate in the progression of mouse prostate tumourigenesis.

Autor: Jeffrey C Francis, Afshan McCarthy, Martin K Thomsen, Alan Ashworth, Amanda Swain

Publikováno v: PLoS Genetics, Vol 6, Iss 6, p e1000995 (2010)

Epidemiological studies have shown that one of the strongest risk factors for prostate cancer is a family history of the disease, suggesting that inherited factors play a major role in prostate cancer susceptibility. Germline mutations in BRCA2 predi

Externí odkaz: https://doaj.org/article/50e576c66c604d56ad9f0758ee5b1737

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Supplementary Methods from Targeting Bromodomain and Extra-Terminal (BET) Family Proteins in Castration-Resistant Prostate Cancer (CRPC)

Supplementary Methods

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15689bea45004b24846a2118e0add6fb
https://doi.org/10.1158/1078-0432.22469723.v1

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Figure Legends from Targeting Bromodomain and Extra-Terminal (BET) Family Proteins in Castration-Resistant Prostate Cancer (CRPC)

Supplementary Figure Legends for Figures S1 to S13

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c0df864a5532cb57994e347abe3b6fa
https://doi.org/10.1158/1078-0432.22469735.v1

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Data from Targeting Bromodomain and Extra-Terminal (BET) Family Proteins in Castration-Resistant Prostate Cancer (CRPC)

Purpose: Persistent androgen receptor (AR) signaling drives castration-resistant prostate cancer (CRPC) and confers resistance to AR-targeting therapies. Novel therapeutic strategies to overcome this are urgently required. We evaluated how bromodomai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48d2c1ad082e063d31f6c285c33a897b
https://doi.org/10.1158/1078-0432.c.6527321

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Supplementary Figures from Targeting Bromodomain and Extra-Terminal (BET) Family Proteins in Castration-Resistant Prostate Cancer (CRPC)

Supplementary Figures S1 to S13 Supplementary Figure S1: Summary of clinical samples analyzed for BRD4 protein expression and SPOP mutational status The clinical samples used in this study were from a population of metastatic castration resistant pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca7a9e8a46fac1cb60e1b8b98950ba00
https://doi.org/10.1158/1078-0432.22469726

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Supplementary Tables from Targeting Bromodomain and Extra-Terminal (BET) Family Proteins in Castration-Resistant Prostate Cancer (CRPC)

Supplementary Tables 1 to 10 Supplementary Table 1: Cell lines ATCC - american type culture collection, FBS - fetal bovine serum, CSS - charcoal stripped serum, * - LNCaP95 cells were kindly provided by Drs. Alan K Meeker and Jun Luo (Johns Hopkins U

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3382aaba13c05a462c8fbc426173c91f
https://doi.org/10.1158/1078-0432.22469720.v1

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Evolutionary selection of alleles in the melanophilin gene that impacts on prostate organ function and cancer risk

Autor: Amanda Swain, Luca Ermini, Mel Greaves, Jian Ning, Gabriel S Rosa, Jeffrey C. Francis, Alexandra J Rose

Publikováno v: Evolution, Medicine, and Public Health

Background and objectives Several hundred inherited genetic variants or SNPs that alter the risk of cancer have been identified through genome-wide association studies. In populations of European ancestry, these variants are mostly present at relativ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b1ca63b060d576c5827f69da5b84a0d
https://doi.org/10.1093/emph/eoab026

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HOX genes promote cell proliferation and are potential therapeutic targets in adrenocortical tumours

Autor: Amanda Swain, Yacob Weinstein, Pierre Val, Jeffrey C. Francis, Jennifer R. Gardiner, Yoan Renaud, Celso E. Gomez-Sanchez, Anne-Marie Lefrançois-Martinez, Ritika Chauhan, Jérôme Bertherat

Publikováno v: British Journal of Cancer
British Journal of Cancer, Cancer Research UK, In press, ⟨10.1038/s41416-020-01166-z⟩
British Journal of Cancer, In press, ⟨10.1038/s41416-020-01166-z⟩

BackgroundUnderstanding the pathways that drive adrenocortical carcinoma (ACC) is essential to the development of more effective therapies. This study investigates the role of the transcription factor HOXB9 and other HOX factors in ACC and its treatm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd1ddaad4a11ba093aaa6c90f167387f
https://hal.archives-ouvertes.fr/hal-03100390

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