Zobrazeno 1 - 10
of 321
pro vyhledávání: '"Jeffrey C, Rathmell"'
Autor:
Lisa Tucker, Umer Ali, Roy Zent, Deborah A. Lannigan, Jeffrey C. Rathmell, Venkataswarup Tiriveedhi
Publikováno v:
Cells, Vol 13, Iss 11, p 912 (2024)
Several chronic inflammatory diseases have been linked to high-salt (HS) diets. Chronic inflammation is an established causative hallmark of cancer. However, a direct role of HS diets in tumorigenesis is yet to be defined. Previous orthotopic murine
Externí odkaz:
https://doaj.org/article/0629d031c7a04701a585edf9b85fcd7f
Autor:
Konjeti R. Sekhar, Simona G. Codreanu, Olivia C. Williams, Jeffrey C. Rathmell, W. Kimryn Rathmell, John A. McLean, Stacy D. Sherrod, Naira Baregamian
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
IntroductionWe successfully developed a broad spectrum of patient-derived endocrine organoids (PDO) from benign and malignant neoplasms of thyroid, parathyroid, and adrenal glands. In this study, we employed functionally intact parathyroid PDOs from
Externí odkaz:
https://doaj.org/article/42c58611fb444e2e9c4d865f9c1364d3
Autor:
Ly Pham, Padmini Komalavilas, Alex M. Eddie, Timothy E. Thayer, Dalton L. Greenwood, Ken H. Liu, Jaclyn Weinberg, Andrew Patterson, Joshua P. Fessel, Kelli L. Boyd, Jenny C. Schafer, Jamie L. Kuck, Aaron C. Shaver, David K. Flaherty, Brittany K. Matlock, Christiaan D. M. Wijers, C. Henrique Serezani, Dean P. Jones, Evan L. Brittain, Jeffrey C. Rathmell, Michael J. Noto
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
Cpt1a-dependent fatty acid beta-oxidation is found to regulate neutrophil trafficking to the site of infection in a mouse model of pneumonia and is found to play a role in pneumonia susceptibility in humans.
Externí odkaz:
https://doaj.org/article/d76a7386c54d4c2f854b839fc40b5550
Autor:
Hong Yuen Wong, Quanhu Sheng, Amanda B. Hesterberg, Sarah Croessmann, Brenda L. Rios, Khem Giri, Jorgen Jackson, Adam X. Miranda, Evan Watkins, Kerry R. Schaffer, Meredith Donahue, Elizabeth Winkler, David F. Penson, Joseph A. Smith, S. Duke Herrell, Amy N. Luckenbaugh, Daniel A. Barocas, Young J. Kim, Diana Graves, Giovanna A. Giannico, Jeffrey C. Rathmell, Ben H. Park, Jennifer B. Gordetsky, Paula J. Hurley
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
The molecular and cellular underpinnings of cribriform prostate cancer aggressiveness remain to be explored. Here, the authors perform single-cell RNA-sequencing, TCR sequencing and histology and reveal cancer cell intrinsic pathways and an immunosup
Externí odkaz:
https://doaj.org/article/4bcf1d4886244b9c998c5bc32d758a97
Autor:
Minghao Gong, Seung-Chul Choi, Yuk Pheel Park, Xueyang Zou, Ahmed S. Elshikha, Valerie A. Gerriets, Jeffrey C. Rathmell, Mansour Mohamazadeh, Laurence Morel
Publikováno v:
iScience, Vol 26, Iss 5, Pp 106774- (2023)
Summary: The expansion of follicular helper T (Tfh) cells, which is tightly associated with the development of lupus, is reversed by the inhibition of either glycolysis or glutaminolysis in mice. Here we analyzed the gene expression and metabolome of
Externí odkaz:
https://doaj.org/article/777af55b261642a996bb8a26db066cb2
Autor:
Huihui Li, Caroline Guglielmetti, Yoshitaka J. Sei, Misha Zilberter, Lydia M. Le Page, Lauren Shields, Joyce Yang, Kevin Nguyen, Brice Tiret, Xiao Gao, Neal Bennett, Iris Lo, Talya L. Dayton, Martin Kampmann, Yadong Huang, Jeffrey C. Rathmell, Matthew Vander Heiden, Myriam M. Chaumeil, Ken Nakamura
Publikováno v:
Cell Reports, Vol 42, Iss 4, Pp 112335- (2023)
Summary: Neurons require large amounts of energy, but whether they can perform glycolysis or require glycolysis to maintain energy remains unclear. Using metabolomics, we show that human neurons do metabolize glucose through glycolysis and can rely o
Externí odkaz:
https://doaj.org/article/5e1e130f24524f59b205438e36d2ce00
Autor:
Kevin J. Kramer, Erin M. Wilfong, Kelsey Voss, Sierra M. Barone, Andrea R. Shiakolas, Nagarajan Raju, Caroline E. Roe, Naveenchandra Suryadevara, Lauren M. Walker, Steven C. Wall, Ariana Paulo, Samuel Schaefer, Debolanle Dahunsi, Camille S. Westlake, James E. Crowe, Robert H. Carnahan, Jeffrey C. Rathmell, Rachel H. Bonami, Ivelin S. Georgiev, Jonathan M. Irish
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Vaccination against COVID-19 has shown activation of different immune cell types. Here the authors characterise the immune response to the SARS-CoV-2 mRNA vaccine using longitudinal CyTOF single cell approaches to characterise antigen specific B and
Externí odkaz:
https://doaj.org/article/54f0d07dda6a4419baae2ec37e6174d0
Autor:
Evan B. Glass, Alyssa A. Hoover, Kennady K. Bullock, Matthew Z. Madden, Bradley I. Reinfeld, Whitney Harris, Dominique Parker, Demetra H. Hufnagel, Marta A. Crispens, Dineo Khabele, W. Kimryn Rathmell, Jeffrey C. Rathmell, Andrew J. Wilson, Todd D. Giorgio, Fiona E. Yull
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-19 (2022)
Abstract Background Current cancer immunotherapies have made tremendous impacts but generally lack high response rates, especially in ovarian cancer. New therapies are needed to provide increased benefits. One understudied approach is to target the l
Externí odkaz:
https://doaj.org/article/695878c019a54c44a19092e66e5e5079
Autor:
Ying Huang, Yujing Zou, Yiqun Jiao, Peijie Shi, Xiaoli Nie, Wei Huang, Chuanfeng Xiong, Michael Choi, Charles Huang, Andrew N. Macintyre, Amanda Nichols, Fang Li, Chuan-Yuan Li, Nancie J. MacIver, Diana M. Cardona, Todd V. Brennan, Zhiguo Li, Nelson J. Chao, Jeffrey C. Rathmell, Benny J. Chen
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Alloreactive donor T cells undergo extensive metabolic reprogramming to become activated and induce graft-versus-host disease (GVHD) upon alloantigen encounter. It is generally thought that glycolysis, which promotes T cell growth and clonal expansio
Externí odkaz:
https://doaj.org/article/f4704c5674ee445191424cee8c3df48c
Autor:
Fathima A. Mohamed, Govindarajan Thangavelu, Stephanie Y. Rhee, Peter T. Sage, Roddy S. O’Connor, Jeffrey C. Rathmell, Bruce R. Blazar
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The therapeutic efficacy of allogeneic hematopoietic stem cell transplantation (allo-HSCT) is limited by the development of graft-versus-host disease (GVHD). In GVHD, rigorous pre-conditioning regimen resets the immune landscape and inflammatory mili
Externí odkaz:
https://doaj.org/article/bfe4afcb6fa14c9e8bf1e70dbb2ca343