Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Jeffrey C, Nolz"'
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Tissue-resident memory (TRM) CD8+ T cells are largely derived from recently activated effector T cells, but the mechanisms that control the extent of TRM differentiation within tissue microenvironments remain unresolved. Here, using an IFNγ
Externí odkaz:
https://doaj.org/article/98659d4192e840ac935c48162957b947
Autor:
Jake C. Harbour, Mahmoud Abdelbary, John B. Schell, Samantha P. Fancher, Jack J. McLean, Taylen J. Nappi, Susan Liu, Timothy J. Nice, Zheng Xia, Klaus Früh, Jeffrey C. Nolz
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112407- (2023)
Summary: Poxvirus infections of the skin are a recent emerging public health concern, yet the mechanisms that mediate protective immunity against these viral infections remain largely unknown. Here, we show that T helper 1 (Th1) memory CD4+ T cells a
Externí odkaz:
https://doaj.org/article/6e4c0481da4d4781a64b5fe1b2ada48a
Autor:
Ravi F Iyer, David M Edwards, Philipp Kolb, Hans-Peter Raué, Chris A Nelson, Megan L Epperson, Mark K Slifka, Jeffrey C Nolz, Hartmut Hengel, Daved H Fremont, Klaus Früh
Publikováno v:
PLoS Pathogens, Vol 18, Iss 9, p e1010783 (2022)
The genome of cowpoxvirus (CPXV) could be considered prototypical for orthopoxviridae (OXPV) since it contains many open reading frames (ORFs) absent or lost in other OPXV, including vaccinia virus (VACV). These additional ORFs are non-essential for
Externí odkaz:
https://doaj.org/article/e93fab86cb334618aa4ef512794423a5
Autor:
Samuel J. Hobbs, Jeffrey C. Nolz
Publikováno v:
Cell Reports, Vol 29, Iss 10, Pp 2990-2997.e2 (2019)
Summary: Tissue-resident memory (TRM) CD8+ T cells are positioned within environmental barrier tissues to provide a first line of defense against pathogen entry, but whether these specialized T cell populations can be readily boosted to increase prot
Externí odkaz:
https://doaj.org/article/a4cf61dba11045efa8bdec4e80349954
Autor:
Christopher P. Loo, Nicholas A. Nelson, Ryan S. Lane, Jamie L. Booth, Sofia C. Loprinzi Hardin, Archana Thomas, Mark K. Slifka, Jeffrey C. Nolz, Amanda W. Lund
Publikováno v:
Cell Reports, Vol 20, Iss 13, Pp 3176-3187 (2017)
Lymphatic vessels lie at the interface between peripheral sites of pathogen entry, adaptive immunity, and the systemic host. Though the paradigm is that their open structure allows for passive flow of infectious particles from peripheral tissues to l
Externí odkaz:
https://doaj.org/article/583a95819dd04ca3bbd3ef5cf647b77c
Autor:
Jossef F Osborn, Samuel J Hobbs, Jana L Mooster, Tahsin N Khan, Augustus M Kilgore, Jake C Harbour, Jeffrey C Nolz
Publikováno v:
PLoS Pathogens, Vol 15, Iss 3, p e1007633 (2019)
Memory CD8+ T cells in the circulation rapidly infiltrate non-lymphoid tissues following infection and provide protective immunity in an antigen-specific manner. However, the subsequent fate of memory CD8+ T cells after entering non-lymphoid tissues
Externí odkaz:
https://doaj.org/article/3d83680066fd4304be459b61fd72a3bb
Autor:
Jake C. Harbour, Mark K. Slifka, William B. Messer, Jeffrey C. Nolz, Zoe L Lyski, John B. Schell, Archana Thomas
Publikováno v:
J Immunol
The COVID-19 pandemic is a global health emergency, and the development of a successful vaccine will ultimately be required to prevent the continued spread and seasonal recurrence of this disease within the human population. However, very little is k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22335aadb94e08e91966576a46131f8e
https://doi.org/10.4049/jimmunol.2100054
https://doi.org/10.4049/jimmunol.2100054
Autor:
Samuel J. Hobbs, Jeffrey C. Nolz
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Selectins constitute a family of oligosaccharide binding proteins that play critical roles in regulating the trafficking of leukocytes. In T cells, L-selectin (CD62L) controls the capacity for naive and memory T cells to actively survey peripheral ly
Externí odkaz:
https://doaj.org/article/13daa38c3e274575b3de0ef81a7253e5
Autor:
Madeline J. Churchill, Haley du Bois, Taylor A. Heim, Tenny Mudianto, Maria M. Steele, Jeffrey C. Nolz, Amanda W. Lund
Publikováno v:
Journal of Experimental Medicine. 219
Lymphatic vessels are often considered passive conduits that flush antigenic material, pathogens, and cells to draining lymph nodes. Recent evidence, however, suggests that lymphatic vessels actively regulate diverse processes from antigen transport
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c95e0609f7a4ad0cc5e3ccd447be56e0
https://doi.org/10.1084/jem.20211830
https://doi.org/10.1084/jem.20211830
Autor:
Jeffrey C. Nolz, Martin J. Richer
Publikováno v:
Molecular Immunology. 117:180-188
IL-15 is a member of the common gamma chain family of cytokines and plays important roles in regulating several aspects of innate and adaptive immunity. Besides its established role in controlling homeostatic proliferation and survival of memory CD8+
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b55f76b80e45468ddb22b02c21fd603
https://doi.org/10.1016/j.molimm.2019.11.011
https://doi.org/10.1016/j.molimm.2019.11.011