Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Jeffrey Breu"'
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 93:4033-4040
Obesity is characterized by reduced GH secretion, but data regarding IGF-I levels and their determinants are conflicting.The objectives were to determine whether IGF-I levels are reduced and to investigate determinants of GH and IGF-I in healthy over
Autor:
Avichal Aggarwal, David B. Herzog, Cecilia Almazan, Jeffrey Breu, Anne Klibanski, Gregory Neubauer, Madhusmita Misra, Kavitha Ramaswamy, Karen K. Miller
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 89:3486-3495
Anorexia nervosa (AN) is associated with very low levels of leptin, a cytokine secreted by adipose tissue and known to suppress appetite. Leptin may play a permissive role in onset of puberty and in resumption of gonadal function in conditions of und
Autor:
Steven K. Grinspoon, Bridget Canavan, Michael L. Johnson, Polyxeni Koutkia, Alex M. DePaoli, Jeffrey Breu
Publikováno v:
The American Journal of Clinical Nutrition. 79:1103-1109
Background: HIV-infected patients are affected by changes in fat distribution, ie, significant losses of subcutaneous fat in association with metabolic abnormalities. Objective: The objective was to investigate the relation between leptin secretion a
Publikováno v:
Biochemical Journal. 327:245-249
The amyloid precursor protein (APP) of Alzheimer's disease is a transmembrane protein that is cleaved by an uncharacterized enzyme known as α-secretase within its extracellular/intraluminal domain after the activation of guanine nucleotide-binding p
Publikováno v:
Journal of Biological Chemistry. 270:8337-8344
Stimulation of m1 and m3 muscarinic acetylcholine receptors, which are coupled to phosphoinositide hydrolysis and protein kinase C activation, has been shown to increase the release of soluble amyloid precursor protein derivatives (APPs). The effect
Publikováno v:
Biochemical Journal. 305:621-626
Phorbol 12-myristate 13-acetate (PMA) stimulated radiolabelled choline uptake and incorporation into phosphatidylcholine (PtdCho) in a time- and concentration-dependent manner in wild-type NIH 3T3 fibroblasts. The accumulation of labelled choline ind
Publikováno v:
Journal of Biological Chemistry. 266:24503-24508
The involvement of endogenous diacylglycerol production in the stimulation of phosphatidylcholine synthesis by exogenous phospholipase C was examined using a neuroblastoma (LA-N-2) cell line. Phospholipase C treatment (0.1 unit/ml) of intact cells st
Autor:
David B. Herzog, Anne Klibanski, Steven K. Grinspoon, Karen K. Miller, Suzanne Gleysteen, Kelly A. Grieco, Julia Ciampa, Jeffrey Breu
Publikováno v:
The Journal of clinical endocrinology and metabolism. 89(9)
Anorexia nervosa (AN) is characterized by low weight and self-imposed caloric restriction and leads to severe bone loss. Although amenorrhea due to acquired GnRH deficiency is nearly universal in AN, a subset of patients maintains menses despite low
Autor:
Avichal Aggarwal, Jeffrey Breu, Kavitha Ramaswamy, Madhusmita Misra, David B. Herzog, Cecilia Almazan, Anne Klibanski, Gregory Neubauer, Karen K. Miller
Publikováno v:
The Journal of clinical endocrinology and metabolism. 89(4)
Anorexia nervosa (AN) is associated with high levels of GH and low levels of IGF-I suggestive of a nutritionally acquired lack of GH action or GH resistance. The suppression of GH levels after administration of inhibitors of GH secretion such as oral
Autor:
Steven K. Grinspoon, Colleen Hadigan, Negar Aliabadi, Gary Meininger, Jessica Rabe, Jeffrey Breu
Publikováno v:
The American journal of clinical nutrition. 77(2)
BACKGROUND Fatty acid concentrations are increased in patients with HIV and fat redistribution and may contribute to insulin resistance in this population. OBJECTIVE We determined the effects of acute inhibition of lipolysis on insulin sensitivity in