Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Jeffrey Baust"'
Autor:
Rebecca R. Vanderpool, Anastasia Gorelova, Yiran Ma, Mohammad Alhamaydeh, Jeffrey Baust, Sruti Shiva, Stevan P. Tofovic, Jian Hu, Seyed Mehdi Nouraie, Mark T. Gladwin, Maryam Sharifi-Sanjani, Imad Al Ghouleh
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 10, p 5426 (2022)
Prostacyclin analogs are among the most effective and widely used therapies for pulmonary arterial hypertension (PAH). However, it is unknown whether they also confer protection through right ventricle (RV) myocardio-specific mechanisms. Moreover, th
Externí odkaz:
https://doaj.org/article/ba858a8e30fd46d98b5344b4e5303627
Autor:
Maryam Sharifi-Sanjani, Mariah Berman, Dmitry Goncharov, Mohammad Alhamaydeh, Theodore Guy Avolio, Jeffrey Baust, Baojun Chang, Ahasanul Kobir, Mark Ross, Claudette St. Croix, Seyed Mehdi Nouraie, Charles F. McTiernan, Christine S. Moravec, Elena Goncharova, Imad Al Ghouleh
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 11, p 6164 (2021)
Left ventricular (LV) heart failure (HF) is a significant and increasing cause of death worldwide. HF is characterized by myocardial remodeling and excessive fibrosis. Transcriptional co-activator Yes-associated protein (Yap), the downstream effector
Externí odkaz:
https://doaj.org/article/dcee4e1c788d48fdb859c3873db78630
Autor:
Yuanjun Shen, Dmitry A. Goncharov, Andressa Pena, Jeffrey Baust, Andres Chavez Barragan, Arnab Ray, Analise Rode, Timothy N. Bachman, Baojun Chang, Lifeng Jiang, Paul Dieffenbach, Laura E. Fredenburgh, Mauricio Rojas, Horace DeLisser, Ana L. Mora, Tatiana V. Kudryashova, Elena A. Goncharova
Publikováno v:
Science Signaling. 15
Increased proliferation and survival of cells in small pulmonary arteries (PAs) drive pulmonary arterial hypertension (PAH). Because cell growth mediated by the mTOR-containing mTORC1 complex is inhibited by tuberous sclerosis complex 2 (TSC2), we in
Autor:
Anastasia Gorelova, Mariah Berman, Maryam Sharifi-Sanjani, Andres Pulgarin Rocha, Anas Alsuraimi, Patricia Riva, Vinny Negi, Thomas Bertero, Dmitry Goncharov, Tatiana Kudryashova, Atinuke Dosunmu-Ogunbi, Arun Rajaratnam, Lloyd Harvey, Mehdi Nouraie, Jeffrey Baust, Timothy Bachman, Andrea Sebastiani, John Sembrat, Sara O. Vargas, Aaron B. Waxman, Rajan Saggar, Rahul Kumar, Brian Graham, Adam C. Straub, Elena A. Goncharova, Ana Mora, Stephen Y. Chan, Imad Al Ghouleh
ObjectivePulmonary hypertension (PH) is a cardiopulmonary disease manifesting in increased pulmonary arterial pressure and right ventricular dysfunction. PH pathogenesis involves extensive pulmonary vascular remodeling precipitated, at least in part,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53447361f5aac8c3c0c74d31db8f28cc
https://doi.org/10.1101/2022.05.31.494181
https://doi.org/10.1101/2022.05.31.494181
Autor:
Tatiana V. Kudryashova, Swati Dabral, Sreenath Nayakanti, Arnab Ray, Dmitry A. Goncharov, Theodore Avolio, Yuanjun Shen, Analise Rode, Andressa Pena, Lifeng Jiang, Derek Lin, Jeffrey Baust, Timothy N. Bachman, Johannes Graumann, Clemens Ruppert, Andreas Guenther, Mario Schmoranzer, Yann Grobs, Sarah Eve Lemay, Eve Tremblay, Sandra Breuils-Bonnet, Olivier Boucherat, Ana L. Mora, Horace DeLisser, Jing Zhao, Yutong Zhao, Sébastien Bonnet, Werner Seeger, Soni S. Pullamsetti, Elena A. Goncharova
Publikováno v:
Circulation research, vol 130, iss 5
Circ Res
Circ Res
Rationale: The MSTs (mammalian Ste20-like kinases) 1/2 are members of the HIPPO pathway that act as growth suppressors in adult proliferative diseases. Pulmonary arterial hypertension (PAH) manifests by increased proliferation and survival of pulmona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5416620a6cb4d33ae500b90e9112d7fa
https://escholarship.org/uc/item/5f69r333
https://escholarship.org/uc/item/5f69r333
Autor:
Katherine Wood, Brittany Durgin, Heidi M Schmidt, Scott Hahn, Jeffrey Baust, Tim Bachman, Dario A. Vitturi, Samit Ghosh, Solomon Fiifi Ofori-Acquah, Ana Mora, Mark T Gladwin, Adam Straub
Publikováno v:
Blood. 134:3619-3619
Pulmonary and systemic vasculopathy are significant risk factors for early morbidity and death in patients with sickle cell disease (SCD). An underlying mechanism of SCD vasculopathy is vascular smooth muscle (VSM) nitric oxide (NO) resistance, which
Autor:
Neil Kelly, Mohammad Alhamaydeh, Alexander Hoyt, Stephanie Mutchler, Megan Yeung, Jeffrey Baust, Imad Al Ghouleh
Publikováno v:
Circulation. 136
Introduction & Hypothesis: The molecular mechanisms underlying right ventricle (RV) hypertrophic remodeling (both adaptive and maladaptive) in response to sustained pressure overload, such as that experienced during pulmonary hypertension (PH), are i