Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Jeffrey Bajko"'
Publikováno v:
FASEB BioAdvances, Vol 2, Iss 9, Pp 526-537 (2020)
Abstract Cystic Fibrosis (CF), an inherited multi‐system disease, is caused by mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) that disrupt its ability to secrete anions from epithelia. Recovery of functional anion secre
Externí odkaz:
https://doaj.org/article/226b8725f8634eb099cd8b16bb7bd856
Autor:
Agnes Gardet, Wei C Chou, Taylor L Reynolds, Diana B Velez, Kai Fu, Julia M Czerkowicz, Jeffrey Bajko, Ann M Ranger, Normand Allaire, Hannah M Kerns, Sarah Ryan, Holly M Legault, Robert W Dunstan, Robert Lafyatis, Matvey Lukashev, Joanne L Viney, Jeffrey L Browning, Dania Rabah
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0164423 (2016)
Mouse models lupus nephritis (LN) have provided important insights into disease pathogenesis, although none have been able to recapitulate all features of the human disease. Using comprehensive longitudinal analyses, we characterized a novel accelera
Externí odkaz:
https://doaj.org/article/de2edfb8f586497f81cac95be2baa6e6
Autor:
Brendan Jones, Hui Su, Audesh Bhat, Hong Lei, Jeffrey Bajko, Sarah Hevi, Gretchen A Baltus, Shilpa Kadam, Huili Zhai, Reginald Valdez, Susana Gonzalo, Yi Zhang, En Li, Taiping Chen
Publikováno v:
PLoS Genetics, Vol 4, Iss 9, p e1000190 (2008)
Dot1 is an evolutionarily conserved histone methyltransferase specific for lysine 79 of histone H3 (H3K79). In Saccharomyces cerevisiae, Dot1-mediated H3K79 methylation is associated with telomere silencing, meiotic checkpoint control, and DNA damage
Externí odkaz:
https://doaj.org/article/419bf84be62d40f1b2de2350fbbcee78
Publikováno v:
FASEB BioAdvances, Vol 2, Iss 9, Pp 526-537 (2020)
FASEB BioAdvances
FASEB BioAdvances
Cystic Fibrosis (CF), an inherited multi‐system disease, is caused by mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) that disrupt its ability to secrete anions from epithelia. Recovery of functional anion secretion may
Autor:
Dania Rabah, Sarah Ryan, Robert Dunstan, Julia M. Czerkowicz, Taylor L. Reynolds, Kai Fu, Normand Allaire, Jeffrey L. Browning, Matvey E. Lukashev, Agnes Gardet, Joanne L. Viney, Wei C. Chou, Ann Ranger, Hannah M. Kerns, Jeffrey Bajko, Holly M. Legault, Diana B. Velez, Robert Lafyatis
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0164423 (2016)
PLoS ONE
PLoS ONE
Mouse models lupus nephritis (LN) have provided important insights into disease pathogenesis, although none have been able to recapitulate all features of the human disease. Using comprehensive longitudinal analyses, we characterized a novel accelera
Autor:
Anke M Schulte, Seng H. Cheng, Cliff Kremer, Kristin M. Taylor, Birgit Meyer-Puttlitz, Ronald K. Scheule, Jeffrey Bajko, Rodney J Morel, Mario S Cabrera
Publikováno v:
Journal of Diabetes & Metabolism.
The mammalian target of rapamycin complex 1 (mTORC1) regulates insulin-mediated glucose metabolism, cell proliferation, the oxidative branch of the pentose phosphate pathway, de novo lipogenesis, and autophagy. Ribosomal S6 kinase 1 (S6K1) and 2 (S6K
Autor:
David N. Ciccone, Hui Su, Sarah Hevi, Frédérique Gay, Hong Lei, Jeffrey Bajko, Guoliang Xu, En Li, Taiping Chen
Publikováno v:
Nature. 461(7262)
Differential DNA methylation of the paternal and maternal alleles regulates the parental origin-specific expression of imprinted genes in mammals. The methylation imprints are established in male and female germ cells during gametogenesis, and the de
Autor:
Audesh Bhat, Shilpa Kadam, Taiping Chen, Gretchen A. Baltus, Hui Su, Jeffrey Bajko, Hong Lei, Huili Zhai, Brendan Jones, Yi Zhang, Sarah Hevi, Reginald Valdez, Susana Gonzalo, En Li
Publikováno v:
PLoS Genetics, Vol 4, Iss 9, p e1000190 (2008)
PLoS Genetics
PLoS Genetics
Dot1 is an evolutionarily conserved histone methyltransferase specific for lysine 79 of histone H3 (H3K79). In Saccharomyces cerevisiae, Dot1-mediated H3K79 methylation is associated with telomere silencing, meiotic checkpoint control, and DNA damage
Autor:
Jing Wang, Sarah Hevi, Julia K Kurash, Hong Lei, Frédérique Gay, Jeffrey Bajko, Hui Su, Weitao Sun, Hua Chang, Guoliang Xu, François Gaudet, En Li, Taiping Chen
Publikováno v:
Nature genetics. 41(1)
Histone methylation and DNA methylation cooperatively regulate chromatin structure and gene activity. How these two systems coordinate with each other remains unclear. Here we study the biological function of lysine-specific demethylase 1 (LSD1, also