Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Jeffrey B. Bonanno"'
Autor:
Natalia Cheshenko, Jeffrey B. Bonanno, Hans-Heinrich Hoffmann, Rohit K. Jangra, Kartik Chandran, Charles M. Rice, Steven C. Almo, Betsy C. Herold
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)
Abstract Herpes simplex virus (HSV) receptor engagement activates phospholipid scramblase triggering Akt translocation to the outer leaflet of the plasma membrane where its subsequent phosphorylation promotes viral entry. We hypothesize that this pre
Externí odkaz:
https://doaj.org/article/866ea4e637e248b58ed8a93146f4518b
Autor:
Natalia Cheshenko, Jeffrey B. Bonanno, Hans-Heinrich Hoffmann, Rohit K. Jangra, Kartik Chandran, Charles M. Rice, Steven C. Almo, Betsy C. Herold
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/4d1acc8e80fd4e28a655751b6003208d
Autor:
Natalia G. Herrera, Nicholas C. Morano, Alev Celikgil, George I. Georgiev, Ryan J. Malonis, James H. Lee, Karen Tong, Olivia Vergnolle, Aldo B. Massimi, Laura Y. Yen, Alex J. Noble, Mykhailo Kopylov, Jeffrey B. Bonanno, Sarah C. Garrett-Thomson, David B. Hayes, Robert H. Bortz, Ariel S. Wirchnianski, Catalina Florez, Ethan Laudermilch, Denise Haslwanter, J. Maximilian Fels, M. Eugenia Dieterle, Rohit K. Jangra, Jason Barnhill, Amanda Mengotto, Duncan Kimmel, Johanna P. Daily, Liise-anne Pirofski, Kartik Chandran, Michael Brenowitz, Scott J. Garforth, Edward T. Eng, Jonathan R. Lai, Steven C. Almo
Publikováno v:
ACS Omega, Vol 6, Iss 1, Pp 85-102 (2020)
Externí odkaz:
https://doaj.org/article/8225fcf771154e9c93f8122d956b1bc4
Autor:
Ariel Lewis-Ballester, Khoa N. Pham, Dipanwita Batabyal, Shay Karkashon, Jeffrey B. Bonanno, Thomas L. Poulos, Syun-Ru Yeh
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
Human indoleamine 2,3-dioxygenase 1 (hIDO1) is an immunotherapeutic target for cancer therapy. Here, the authors present the substrate-, inhibitor- and effector-bound hIDO1 crystal structures, which give insights into the mechanism and reveal a secon
Externí odkaz:
https://doaj.org/article/f8b733a4df2546f48fc72aa65deeac3d
Autor:
Scott T. Lefurgy, Emilia Caselli, Magdalena A. Taracila, Vladimir N. Malashkevich, Beena Biju, Krisztina M. Papp-Wallace, Jeffrey B. Bonanno, Fabio Prati, Steven C. Almo, Robert A. Bonomo
Publikováno v:
Biomolecules, Vol 10, Iss 5, p 671 (2020)
Boronic acid transition-state analog inhibitors (BATSIs) are partners with β-lactam antibiotics for the treatment of complex bacterial infections. Herein, microbiological, biochemical, and structural findings on four BATSIs with the FOX-4 cephamycin
Externí odkaz:
https://doaj.org/article/197e20aff7954e00a0784de10a5f4d91
Autor:
Meng-Chiao Ho, Carola Wilczek, Jeffrey B. Bonanno, Li Xing, Janina Seznec, Tsutomu Matsui, Lester G. Carter, Takashi Onikubo, P. Rajesh Kumar, Man K. Chan, Michael Brenowitz, R. Holland Cheng, Ulf Reimer, Steven C. Almo, David Shechter
Publikováno v:
PLoS ONE, Vol 8, Iss 8 (2013)
Externí odkaz:
https://doaj.org/article/e15886e2426246ed86587d7fc3363ff3
Publikováno v:
Acta Crystallogr F Struct Biol Commun
Chromatin is the complex assembly of nucleic acids and proteins that makes up the physiological form of the eukaryotic genome. The nucleosome is the fundamental repeating unit of chromatin, and is composed of ∼147 bp of DNA wrapped around a histone
Autor:
Steven C. Almo, Benjamin M. Lorton, David Shechter, Rajesh K. Harijan, Emmanuel S. Burgos, Jeffrey B. Bonanno
Publikováno v:
Biochemistry
Histone H3 arginine 2 (H3R2) is post-translationally modified in three different states by “writers” of the protein arginine methyltransferase (PRMT) family. H3R2 methylarginine isoforms include PRMT5-catalyzed mono- and symmetric di-methylation
Autor:
Natalia Cheshenko, Jeffrey B. Bonanno, Hans-Heinrich Hoffmann, Rohit K. Jangra, Kartik Chandran, Charles M. Rice, Steven C. Almo, Betsy C. Herold
Publikováno v:
Communications biology. 5(1)
Herpes simplex virus (HSV) receptor engagement activates phospholipid scramblase triggering Akt translocation to the outer leaflet of the plasma membrane where its subsequent phosphorylation promotes viral entry. We hypothesize that this previously u
Autor:
Udupi A. Ramagopal, Mitchell Kronenberg, Scott J. Garforth, Ting-Fang Chou, Kiyokazu Kakugawa, Kenneth Kim, Steven C. Almo, Elena V. Fedorov, Hilde Cheroutre, Sarah C. Garrett-Thomson, Goo-Young Seo, Jeffrey B. Bonanno, Qingyang Wang, Weifeng Liu
Publikováno v:
The Journal of Experimental Medicine
HVEM is a TNF family receptor that binds a TNF protein and Ig family proteins. Using structural biology and mutagenesis, we identified HVEM muteins with selective ligand binding. We verified their function in vivo in models of inflammation and infect