Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Jeffrey B, Joy"'
Autor:
Natalie N. Kinloch, Aniqa Shahid, Winnie Dong, Don Kirkby, Bradley R. Jones, Charlotte J. Beelen, Daniel MacMillan, Guinevere Q. Lee, Talia M. Mota, Hanwei Sudderuddin, Evan Barad, Marianne Harris, Chanson J. Brumme, R. Brad Jones, Mark A. Brockman, Jeffrey B. Joy, Zabrina L. Brumme
Publikováno v:
mBio, Vol 14, Iss 6 (2023)
ABSTRACTIn order to cure human immunodeficiency virus (HIV), we need to better understand the within-host evolutionary origins of the small reservoir of genome-intact proviruses that persist within infected cells during antiretroviral therapy (ART).
Externí odkaz:
https://doaj.org/article/1447a0402b68443b8658e7d4faad4893
Autor:
François Cholette, Lisa Lazarus, Pascal Macharia, Laura H. Thompson, Samuel Githaiga, John Mathenge, Jeffrey Walimbwa, Irene Kuria, Silvia Okoth, Solomon Wambua, Harrison Albert, Peninah Mwangi, Joyce Adhiambo, Rosemary Kasiba, Esther Juma, Parinita Battacharjee, Joshua Kimani, Paul Sandstrom, Adrienne F. A. Meyers, Jeffrey B. Joy, Matthew Thomann, Paul J. McLaren, Souradet Shaw, Sharmistha Mishra, Marissa L. Becker, Lyle McKinnon, Robert Lorway
Publikováno v:
Global Public Health, Vol 18, Iss 1 (2023)
Inferring HIV transmission networks from HIV sequences is gaining popularity in the field of HIV molecular epidemiology. However, HIV sequences are often analyzed at distance from those affected by HIV epidemics, namely without the involvement of com
Externí odkaz:
https://doaj.org/article/115d74fe140c42a7bba5daf8aa366757
Autor:
Aniqa Shahid, Bradley R Jones, Julia S W Yang, Winnie Dong, Tawimas Shaipanich, Kathryn Donohoe, Chanson J Brumme, Jeffrey B Joy, Janice M Leung, Zabrina L Brumme
Publikováno v:
PLoS Pathogens, Vol 18, Iss 11, p e1010613 (2022)
The lung is an understudied site of HIV persistence. We isolated 898 subgenomic proviral sequences (nef) by single-genome approaches from blood and lung from nine individuals on long-term suppressive antiretroviral therapy (ART), and characterized ge
Externí odkaz:
https://doaj.org/article/b8375e0e10134f47b56087abcbfb4199
Autor:
Angela McLaughlin, Vincent Montoya, Rachel L Miller, Gideon J Mordecai, Canadian COVID-19 Genomics Network (CanCOGen) Consortium, Michael Worobey, Art FY Poon, Jeffrey B Joy
Publikováno v:
eLife, Vol 11 (2022)
Tracking the emergence and spread of SARS-CoV-2 lineages using phylogenetics has proven critical to inform the timing and stringency of COVID-19 public health interventions. We investigated the effectiveness of international travel restrictions at re
Externí odkaz:
https://doaj.org/article/1bc4afbbea994902993e6ec02d094e4d
Autor:
Vincent Montoya, Anita Y. M. Howe, Weiyan Y. Dong, Winnie Dong, Chanson J. Brumme, Andrea D. Olmstead, Kanna Hayashi, P. Richard Harrigan, Jeffrey B. Joy
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Most individuals chronically infected with hepatitis C virus (HCV) are asymptomatic during the initial stages of infection and therefore the precise timing of infection is often unknown. Retrospective estimation of infection duration would i
Externí odkaz:
https://doaj.org/article/9897a6ee8ee742759ddb6f3d56a742fb
Autor:
Kaho H Tisthammer, Caroline Solis, Faye Orcales, Madu Nzerem, Ryan Winstead, Weiyan Dong, Jeffrey B Joy, Pleuni S Pennings
Publikováno v:
PLoS Genetics, Vol 18, Iss 5, p e1010179 (2022)
Like many viruses, Hepatitis C Virus (HCV) has a high mutation rate, which helps the virus adapt quickly, but mutations come with fitness costs. Fitness costs can be studied by different approaches, such as experimental or frequency-based approaches.
Externí odkaz:
https://doaj.org/article/b5e2d0b3c4bc4345896f48e4d4449ef2
Autor:
Hanwei Sudderuddin, Natalie N. Kinloch, Steven W. Jin, Rachel L. Miller, Bradley R. Jones, Chanson J. Brumme, Jeffrey B. Joy, Mark A. Brockman, Zabrina L. Brumme
Publikováno v:
Retrovirology, Vol 17, Iss 1, Pp 1-10 (2020)
Abstract The HIV accessory protein Nef downregulates the viral entry receptor CD4, the Human Leukocyte Antigen (HLA)-A and -B molecules, the Serine incorporator 5 (SERINC5) protein and other molecules from the infected cell surface, thereby promoting
Externí odkaz:
https://doaj.org/article/dd7f59c20e0e483ab4cac2ba140f1252
Autor:
F. Harrison Omondi, Hanwei Sudderuddin, Aniqa Shahid, Natalie N. Kinloch, Bradley R. Jones, Rachel L. Miller, Olivia Tsai, Daniel MacMillan, Alicja Trocha, Mark A. Brockman, Chanson J. Brumme, Jeffrey B. Joy, Richard Liang, Bruce D. Walker, Zabrina L. Brumme
Publikováno v:
mBio, Vol 12, Iss 6 (2021)
ABSTRACT Curing HIV will require eliminating the reservoir of integrated, replication-competent proviruses that persist despite antiretroviral therapy (ART). Understanding the burden, genetic diversity, and longevity of persisting proviruses in diver
Externí odkaz:
https://doaj.org/article/e29d5e60d3034aedb7b7c5c53808e009
Autor:
Kelsie Brooks, F. Harrison Omondi, Richard H. Liang, Hanwei Sudderuddin, Bradley R. Jones, Jeffrey B. Joy, Chanson J. Brumme, Eric Hunter, Zabrina L. Brumme
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Human immunodeficiency virus (HIV) can persist as an integrated provirus, in a transcriptionally repressed state, within infected cells. This small yet enduring pool of cellular reservoirs that harbor replication-competent HIV is the main barrier to
Externí odkaz:
https://doaj.org/article/8ff485234fc84014b344a0c98b5515c5
Autor:
Angela McLaughlin, Paul Sereda, Natalia Oliveira, Rolando Barrios, Chanson J. Brumme, Zabrina L. Brumme, Julio S.G. Montaner, Jeffrey B. Joy
Publikováno v:
EBioMedicine, Vol 48, Iss , Pp 405-413 (2019)
Background: Identifying populations at high risk of HIV transmission is critical for prioritizing treatment and prevention resources and achieving the UNAIDS 90-90-90 Targets. Methods: HIV transmission rates can be estimated from phylogenetic trees a
Externí odkaz:
https://doaj.org/article/21e1284d11154437bc8fb787b497c744