Zobrazeno 1 - 10
of 438
pro vyhledávání: '"Jeffrey Aubé"'
Autor:
Hanna Vihma, Kelin Li, Anna Welton-Arndt, Audrey L. Smith, Kiran R. Bettadapur, Rachel B. Gilmore, Eric Gao, Justin L. Cotney, Hsueh-Cheng Huang, Jon L. Collins, Stormy J. Chamberlain, Hyeong-Min Lee, Jeffrey Aubé, Benjamin D. Philpot
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Deletion of the maternal UBE3A allele causes Angelman syndrome (AS); because paternal UBE3A is epigenetically silenced by a long non-coding antisense (UBE3A-ATS) in neurons, this nearly eliminates UBE3A protein in the brain. Reactivating pat
Externí odkaz:
https://doaj.org/article/72e7df6e4aea4466a15644b3c09e8c85
Autor:
Lanjing Wei, Qi Zhang, Cuncong Zhong, Lily He, Yuxia Zhang, Ahlam M. Armaly, Jeffrey Aubé, Danny R. Welch, Liang Xu, Xiaoqing Wu
Publikováno v:
Molecular Oncology, Vol 17, Iss 10, Pp 1962-1980 (2023)
Chemotherapy remains the standard treatment for triple‐negative breast cancer (TNBC); however, chemoresistance compromises its efficacy. The RNA‐binding protein Hu antigen R (HuR) could be a potential therapeutic target to enhance the chemotherap
Externí odkaz:
https://doaj.org/article/7a76c1ec594e40d5afc47174dc9034a1
Autor:
Owen Jensen, Shubhanshi Trivedi, Jackson G. Cacioppo, Kelin Li, Jeffrey Aubé, J. Scott Hale, Edward T. Ryan, Daniel T Leung
Publikováno v:
Pathogens and Immunity, Vol 7, Iss 1 (2022)
ERRATUM TO: USE OF A MAIT ACTIVATING LIGAND, 5-OP-RU, AS A MUCOSAL ADJUVANT IN A MURINE MODEL OF VIBRIO CHOLERAE O1 VACCINATION DOI: 10.20411/pai.v7i1.525 Reason: The authors sincerely regret the inadvertent omission of Jackson G. Cacioppo as coa
Externí odkaz:
https://doaj.org/article/79c872b19acf48c5a94db0ea1e825104
Autor:
Owen Jensen, Shubhanshi Trivedi, Kelin Li, Jeffrey Aubé, J. Scott Hale, Edward T. Ryan, Daniel T Leung
Publikováno v:
Pathogens and Immunity, Vol 7, Iss 1 (2022)
Background: Mucosal-associated invariant T (MAIT) cells are innate-like T cells enriched in the mucosa with capacity for B-cell help. We hypothesize that targeting MAIT cells, using a MAIT-activating ligand as an adjuvant, could improve mucosal vacci
Externí odkaz:
https://doaj.org/article/372cb31122be4d518637e940c22c704a
Autor:
Frances M. Potjewyd, Joel K. Annor‐Gyamfi, Jeffrey Aubé, Shaoyou Chu, Ivie L. Conlon, Kevin J. Frankowski, Shiva K. R. Guduru, Brian P. Hardy, Megan D. Hopkins, Chizuru Kinoshita, Dmitri B. Kireev, Emily R. Mason, Charles T. Moerk, Felix Nwogbo, Kenneth H. Pearce Jr., Timothy I. Richardson, David A. Rogers, Disha M. Soni, Michael Stashko, Xiaodong Wang, Carrow Wells, Timothy M. Willson, Stephen V. Frye, Jessica E. Young, Alison D. Axtman
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 8, Iss 1, Pp n/a-n/a (2022)
Abstract Introduction A chemogenomic set of small molecules with annotated activities and implicated roles in Alzheimer's disease (AD) called the AD Informer Set was recently developed and made available to the AD research community: https://treatad.
Externí odkaz:
https://doaj.org/article/b33c64d9d5fa4d89ad4554a76c6b0930
Autor:
Frances M. Potjewyd, Joel K. Annor‐Gyamfi, Jeffrey Aubé, Shaoyou Chu, Ivie L. Conlon, Kevin J. Frankowski, Shiva K. R. Guduru, Brian P. Hardy, Megan D. Hopkins, Chizuru Kinoshita, Dmitri B. Kireev, Emily R. Mason, Charles T. Moerk, Felix Nwogbo, Kenneth H. Pearce, Timothy I. Richardson, David A. Rogers, Disha M. Soni, Michael Stashko, Xiaodong Wang, Carrow Wells, Timothy M. Willson, Stephen V. Frye, Jessica E. Young, Alison D. Axtman
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 8, Iss 1, Pp n/a-n/a (2022)
Abstract Introduction The portfolio of novel targets to treat Alzheimer's disease (AD) has been enriched by the Accelerating Medicines Partnership Program for Alzheimer's Disease (AMP AD) program. Methods Publicly available resources, such as literat
Externí odkaz:
https://doaj.org/article/e2d6a7a95cd548b0ab470f7102528da7
Autor:
Landys Lopez Quezada, Robert Smith, Tania J. Lupoli, Zainab Edoo, Xiaojun Li, Ben Gold, Julia Roberts, Yan Ling, Sae Woong Park, Quyen Nguyen, Frank J. Schoenen, Kelin Li, Jean-Emmanuel Hugonnet, Michel Arthur, James C. Sacchettini, Carl Nathan, Jeffrey Aubé
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
As β-lactams are reconsidered for the treatment of tuberculosis (TB), their targets are assumed to be peptidoglycan transpeptidases, as verified by adduct formation and kinetic inhibition of Mycobacterium tuberculosis (Mtb) transpeptidases by carbap
Externí odkaz:
https://doaj.org/article/4d560f0f64cb40cc8c57181a0b7ea41e
Autor:
Lan Lan, Hao Liu, Amber R. Smith, Carl Appelman, Jia Yu, Sarah Larsen, Rebecca T. Marquez, Xiaoqing Wu, Frank Y. Liu, Philip Gao, Ragul Gowthaman, John Karanicolas, Roberto N. De Guzman, Steven Rogers, Jeffrey Aubé, Kristi L. Neufeld, Liang Xu
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-14 (2018)
Abstract Background The Musashi (MSI) family of RNA-binding proteins is best known for the role in post-transcriptional regulation of target mRNAs. Elevated MSI1 levels in a variety of human cancer are associated with up-regulation of Notch/Wnt signa
Externí odkaz:
https://doaj.org/article/467b8685db114a03a77638f0b45279ce
Autor:
Manwika Charaschanya, Jeffrey Aubé
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
Late-stage diversification of natural products is an important starting point for drug discovery. Here, the authors use chiral reagents to perform the regiocontrolled ring expansion of steroid precursors and achieve more than 100 isomerically pure an
Externí odkaz:
https://doaj.org/article/c474749e5c3742fcb1e3a9c7bde664bc
Autor:
Landys Lopez Quezada, Sandra Silve, Mark Kelinske, Amir Liba, Constantino Diaz Gonzalez, Martin Kotev, Laurent Goullieux, Stephanie Sans, Christine Roubert, Sophie Lagrange, Eric Bacqué, Cedric Couturier, Alain Pellet, Isabelle Blanc, Marlène Ferron, Fabrice Debu, Kelin Li, Jeffrey Aubé, Julia Roberts, David Little, Yan Ling, Jun Zhang, Ben Gold, Carl Nathan
Publikováno v:
mBio, Vol 10, Iss 4 (2019)
ABSTRACT A defining characteristic of treating tuberculosis is the need for prolonged administration of multiple drugs. This may be due in part to subpopulations of slowly replicating or nonreplicating Mycobacterium tuberculosis bacilli exhibiting ph
Externí odkaz:
https://doaj.org/article/36d78fae9ed74d22a77a85998cdfb018