Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Jeffrey Adijanto"'
Autor:
Jeffrey Adijanto, Muna I. Naash
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 95:353-367
For patients with hereditary retinal diseases, retinal gene therapy offers significant promise for the prevention of retinal degeneration. While adeno-associated virus (AAV)-based systems remain the most popular gene delivery method due to their high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e9125481362399fd7da8a6eb0da391c
https://doi.org/10.1016/j.ejpb.2014.12.028
https://doi.org/10.1016/j.ejpb.2014.12.028
Autor:
Nancy J. Philp, Jeffrey Adijanto
Publikováno v:
Experimental Eye Research. 126:77-84
Mitochondrial dysfunction has been shown to contribute to age-related and proliferative retinal diseases. Over the past decade, the primary human fetal RPE (hfRPE) culture model has emerged as an effective tool for studying RPE function and mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1348cbacefb21d42856df9ef3de39fd5
https://doi.org/10.1016/j.exer.2014.01.015
https://doi.org/10.1016/j.exer.2014.01.015
Autor:
James B. Hurley, Nancy J. Philp, Jianhai Du, Cynthia Moffat, Erin L. Seifert, Jeffrey Adijanto
Publikováno v:
Journal of Biological Chemistry. 289:20570-20582
Every day, shortly after light onset, photoreceptor cells shed approximately a tenth of their outer segment. The adjacent retinal pigment epithelial (RPE) cells phagocytize and digest shed photoreceptor outer segment, which provides a rich source of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9903349fc32b9129a2f4d6867aa561a8
https://doi.org/10.1074/jbc.m114.565457
https://doi.org/10.1074/jbc.m114.565457
Autor:
Jeffrey Adijanto, Tünde Golenár, György Hajnóczky, David Weaver, Sergio de la Fuente Perez, Yasemin Sancak, Cynthia Moffat, Erin L. Seifert, Fabiana Perocchi, Victor Koteliansky, Vamsi K. Mootha, György Csordás, Roman L. Bogorad, Kimberli J. Kamer
Publikováno v:
Cell Metabolism. 17(6):976-987
Summary Mitochondrial Ca 2+ uptake via the uniporter is central to cell metabolism, signaling, and survival. Recent studies identified MCU as the uniporter's likely pore and MICU1, an EF-hand protein, as its critical regulator. How this complex decod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1c9376d3eaa7bd1990acc932db9c63d
Publikováno v:
The Journal of General Physiology
In the intact eye, the transition from light to dark alters pH, [Ca2+], and [K] in the subretinal space (SRS) separating the photoreceptor outer segments and the apical membrane of the retinal pigment epithelium (RPE). In addition to these changes, o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::902370d240cb7238dafa83bc4299eee3
https://doi.org/10.1085/jgp.200810169
https://doi.org/10.1085/jgp.200810169
Autor:
Jeffrey, Adijanto, Nancy J, Philp
Publikováno v:
Current topics in membranes. 70
The SLC16A family of monocarboxylate transporters (MCTs) is composed of 14 members. MCT1 through MCT4 (MCTs 1-4) are H(+)-coupled monocarboxylate transporters, MCT8 and MCT10 transport thyroid hormone and aromatic amino acids, while the substrate spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::643f689552ecf956eec163456f672704
https://pubmed.ncbi.nlm.nih.gov/23177990
https://pubmed.ncbi.nlm.nih.gov/23177990
Autor:
Zixuan Wang, Arvydas Maminishkis, Jeffrey Adijanto, Nancy J. Philp, John J. Castorino, Gerald B. Grunwald
Publikováno v:
The Journal of biological chemistry. 287(24)
The retinal pigment epithelium (RPE) plays a fundamental role in maintaining visual function and dedifferentiation of RPE contributes to the pathophysiology of several ocular diseases. To identify microRNAs (miRNAs) that may be involved in RPE differ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f10dd5729af2c0d9929032a79a16f82a
https://pubmed.ncbi.nlm.nih.gov/22523078
https://pubmed.ncbi.nlm.nih.gov/22523078
Autor:
György, Csordás, Tünde, Golenár, Erin L, Seifert, Kimberli J, Kamer, Yasemin, Sancak, Fabiana, Perocchi, Cynthia, Moffat, David, Weaver, Sergio de la Fuente, Perez, Roman, Bogorad, Victor, Koteliansky, Jeffrey, Adijanto, Vamsi K, Mootha, György, Hajnóczky
Publikováno v:
Cell metabolism. 17(6)
Mitochondrial Ca(2+) uptake via the uniporter is central to cell metabolism, signaling, and survival. Recent studies identified MCU as the uniporter's likely pore and MICU1, an EF-hand protein, as its critical regulator. How this complex decodes dyna
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::edc20787b8878aec6067f20121a8996a
https://pubmed.ncbi.nlm.nih.gov/23747253
https://pubmed.ncbi.nlm.nih.gov/23747253
Autor:
Jeffrey Adijanto, Nancy J. Philp
The SLC16A family of monocarboxylate transporters (MCTs) is composed of 14 members. MCT1 through MCT4 (MCTs 1-4) are H(+)-coupled monocarboxylate transporters, MCT8 and MCT10 transport thyroid hormone and aromatic amino acids, while the substrate spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98c18f08231653297da235a266a6f88e
https://doi.org/10.1016/b978-0-12-394316-3.00009-0
https://doi.org/10.1016/b978-0-12-394316-3.00009-0
We have developed a robust and well-defined primary cell culture model of human fetal retinal pigment epithelium (hfRPE). This model was used to analyze how metabolic waste products produced in the retina can be disposed of by CO2/HCO3 and lactate tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7180097cfbe500032b2aa7adc904a2e2
https://doi.org/10.1016/b978-0-12-374203-2.00184-6
https://doi.org/10.1016/b978-0-12-374203-2.00184-6