Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Jeffrey A. Wald"'
Autor:
Richard V. Clark, Susan Andrews, Ann C. Walker, Mindy Magee, Philip Turnbull, Jeffrey A. Wald
Publikováno v:
British Journal of Clinical Pharmacology. 83:2179-2194
Aim Selective androgen receptor modulators (SARMs) induce anabolic effects on muscle without the adverse effects of androgenic steroids. In this first-in-human study, we report the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics of t
Autor:
Ronald S. Swerdloff, Christina Wang, Alvin M. Matsumoto, Jeffrey A. Wald, Frederick C. W. Wu, Larry D. Bowers, Richard V. Clark
Publikováno v:
Clark, R V, Wald, J A, Swerdloff, R S, Wang, C, Wu, F C W, Bowers, L D & Matsumoto, A M 2018, ' Large divergence in testosterone concentrations between men and women: Frame of reference for elite athletes in sex-specific competition in sports, a narrative review ', Clinical Endocrinology . https://doi.org/10.1111/cen.13840
ObjectiveThe purpose of this narrative review was to summarize available data on testosterone levels in normal, healthy adult males and females, to provide a physiologic reference framework to evaluate testosterone levels reported in males and female
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed779516e1e63b02ecba0b2cfb25d0fd
https://www.research.manchester.ac.uk/portal/en/publications/large-divergence-in-testosterone-concentrations-between-men-and-women-frame-of-reference-for-elite-athletes-in-sexspecific-competition-in-sports-a-narrative-review(a80e41f6-d5ae-42db-86cf-b4f302d89510).html
https://www.research.manchester.ac.uk/portal/en/publications/large-divergence-in-testosterone-concentrations-between-men-and-women-frame-of-reference-for-elite-athletes-in-sexspecific-competition-in-sports-a-narrative-review(a80e41f6-d5ae-42db-86cf-b4f302d89510).html
Autor:
Yaping Liu, Lihong Chen, Frank L. Greenway, Robert L. Dobbins, Chari D. Smith, Susan Andrews, Jeffrey A. Wald, Ann C. Walker, Sharon L Breed
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 308:G946-G954
GSK-1614235 and KGA-2727 are potent, selective inhibitors of the SGLT1 sodium-dependent glucose transporter. Nonclinical (KGA-2727) and clinical (GSK-1614235) trials assessed translation of SGLT1 inhibitor effects from rats to normal human physiology
Autor:
Rickey R. Reinhardt, Rebecca J. Hodge, Rhona Scott, Hui Zhi, Jessica E. Matthews, Malcolm A. Young, Jeffrey A. Wald
Publikováno v:
Postgraduate Medicine. 126:84-97
Albiglutide is a glucagon-like peptide-1 analogue composed of tandem copies of modified human glucagon-like peptide-1 (7-36) coupled to recombinant human albumin that is approved in adults for the treatment of type 2 diabetes mellitus. After subcutan
Publikováno v:
Postgraduate Medicine. 126:35-46
Chronic kidney disease is frequently present in patients with type 2 diabetes mellitus (T2DM). New therapeutic options in this patient subpopulation are needed.Assess the effect of renal impairment on the pharmacokinetics (PK), efficacy, and safety o
Autor:
Richard V, Clark, Ann C, Walker, Susan, Andrews, Philip, Turnbull, Jeffrey A, Wald, Mindy H, Magee
Publikováno v:
British journal of clinical pharmacology. 83(10)
Selective androgen receptor modulators (SARMs) induce anabolic effects on muscle without the adverse effects of androgenic steroids. In this first-in-human study, we report the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics of the S
Autor:
Jeffrey A. Wald, William J. Jusko
Publikováno v:
Life Sciences. 55:PL371-PL378
Leukocytes circulate throughout the body patrolling for foreign antigens and facilitating immune responses. Corticosteroids exert their immunosuppressive actions, in part, by inhibiting the normal trafficking of these cells. The rat was used to inves
Autor:
William J. Jusko, Jeffrey A. Wald
Publikováno v:
Pharmaceutical Research. :1096-1098
Publikováno v:
Life sciences. 55(24)
Nitric oxide (NO) is present in the exhaled breath of humans and experimental animals, but its physiologic role and cellular source(s) remain to be determined. Possible sites of origin are pulmonary endothelial cells and/or resident macrophages. Here
Autor:
Lynn E Fisher, Elliott Middleton, Rita R. Sloan, William J. Jusko, Elizabeth A. Ludwig, Jeffrey A. Wald
Publikováno v:
Clinical pharmacology and therapeutics. 51(6)
The temporal variations in the pharmacokinetics and pharmacodynamics of methylprednisolone at 8 am versus 4 pm were investigated in six healthy male volunteers. Subjects completed three phases: no drug administration, 20 mg intravenous methylpredniso