Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Jeffrey A. Scholten"'
Autor:
John F. Rebhun, Qin Du, Molly Hood, Hailing Guo, Kelly M. Glynn, Hao Cen, Jeffrey D. Scholten, Feng Tian, Min Gui, Minjie Li, Yongfang Zhao
Publikováno v:
Journal of Traditional and Complementary Medicine, Vol 9, Iss 3, Pp 227-235 (2019)
Objective: To investigate the development of a minimal traditional Chinese medicine (TCM) formula using selected TCM ingredients and evaluating their biological activity with bone-specific in vitro tests. Finally, determining if the minimal formula c
Externí odkaz:
https://doaj.org/article/d67b4041eac6405c8cf69dc25eb7af8c
Autor:
MyPhuong T Le, Miguel A Lanaspa, Christina M Cicerchi, Jatinder Rana, Jeffrey D Scholten, Brandi L Hunter, Christopher J Rivard, R Keith Randolph, Richard J Johnson
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0157458 (2016)
OBJECTIVE:In developed countries with westernized diets, the excessive consumption of added sugar in beverages and highly refined and processed foods is associated with increased risk for obesity, diabetes, and cardiovascular diseases. As a major con
Externí odkaz:
https://doaj.org/article/f4ec136321044fe69514eb1be2bcbca3
Autor:
Molly M. Hood, Kelly M. Glynn, Min Gui, Feng Tian, Du Qin, Cen Hao, Minjie Li, John F. Rebhun, Yongfang Zhao, Hailing Guo, Jeffrey D. Scholten
Publikováno v:
Journal of Traditional and Complementary Medicine, Vol 9, Iss 3, Pp 227-235 (2019)
Objective: To investigate the development of a minimal traditional Chinese medicine (TCM) formula using selected TCM ingredients and evaluating their biological activity with bone-specific in vitro tests. Finally, determining if the minimal formula c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e5ace87206fabd014b9a1f2896e9e46
https://doi.org/10.1016/j.jtcme.2017.07.004
https://doi.org/10.1016/j.jtcme.2017.07.004
Publikováno v:
Journal of Food Bioactives. 8
Citrus fruits are a rich source of vitamin C and phytochemicals and can be an important part of a healthy diet. Citrus is believed to prevent the occurrence or shorten the duration of symptoms of the common cold and influenza, but meta-analysis of vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0198e1531ce74a04f5c4bb7f70140b54
https://doi.org/10.31665/jfb.2019.8207
https://doi.org/10.31665/jfb.2019.8207
Autor:
Michael David Rogers, Jeffery N. Carroll, Mark A. Massa, Jeffrey Hitchcock, Peter G. Ruminski, Michelle A. Schmidt, Bruce C. Hamper, Strohbach Joseph Walter, Huey S. Shieh, Laurence O. Whiteley, Katherine E. Palmquist, Joe T. Collins, Grace E. Munie, Hanau Cathleen E, H. Peter Kleine, Mark E. Schnute, T. Sunyer, Nicole Caspers, John E. Baldus, Theresa R. Fletcher, Joseph J. McDonald, Silvia Portolan, Jeffrey A. Scholten, Dean Messing, Margaret L. Grapperhaus, Brandon Collins
Publikováno v:
Journal of Medicinal Chemistry. 59:313-327
Matrix metalloproteinase-13 (MMP-13) is a zinc-dependent protease responsible for the cleavage of type II collagen, the major structural protein of articular cartilage. Degradation of this cartilage matrix leads to the development of osteoarthritis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1bf588f2b187240a5d8f4d5ee2e305b
https://doi.org/10.1021/acs.jmedchem.5b01434
https://doi.org/10.1021/acs.jmedchem.5b01434
Autor:
Maureen K. Highkin, Matthew D. McReynolds, Matthew J. Saabye, John W. Rains, Kaliapan Iyanar, Jeffrey Carroll, Jill Chrencik, Matthew P. Yates, Jeffrey A. Scholten, Gina M. Jerome, Marek M. Nagiec, Mark E. Schnute
Publikováno v:
Journal of medicinal chemistry. 60(6)
Sphingosine kinase (SphK) is the major source of the lipid mediator and G protein-coupled receptor agonist sphingosine-1-phosphate (S1P). S1P promotes cell growth, survival, and migration and is a key regulator of lymphocyte trafficking. Inhibition o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33c23d10cabd117ff2077923f1706da7
https://pubmed.ncbi.nlm.nih.gov/28231433
https://pubmed.ncbi.nlm.nih.gov/28231433
Publikováno v:
Pharmacognosy Magazine. 15:449
Background: An imbalance between oxidative and reductive processes within cells can result in oxidative stress leading to a decrease in cellular survival. Use of natural products with antioxidant properties may reduce this oxidative stress. Objective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba2112b1efd0ae7a03ca796545b7d2ac
https://doi.org/10.4103/pm.pm_556_18
https://doi.org/10.4103/pm.pm_556_18
Autor:
Daniel P. Walker, Alexander F. Shaffer, William M. Moore, Michael T. Baratta, Sue Metz, Jeffrey A. Scholten, John Robert Springer, Jeffrey S. Carter, Hwang-Fun Lu, Steven E. Heasley, Yvette M. Fobian, Natasha M. Kablaoui, Francisco M. Franco, Li Xing, Shengtian Yang, Hanau Cathleen E, Michael L. Vazquez, Graciela B. Arhancet, Gina M. Jerome
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:1120-1126
Microsomal prostaglandin E(2) synthase-1 (mPGES-1) is a novel therapeutic target for the treatment of inflammation and pain. In the preceding letter, we detailed the discovery of clinical candidate PF-04693627, a potent mPGES-1 inhibitor possessing a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2d05bf0698be13f2291735a95c4465f
https://doi.org/10.1016/j.bmcl.2012.11.107
https://doi.org/10.1016/j.bmcl.2012.11.107
Publikováno v:
Fitoterapia. 83:989-995
In an effort to find botanicals containing polyphenolic compounds with the capacity to inhibit melanin biosynthesis, we identified a novel combination of Siberian larch (Larix sibirica) extract, standardized to 80% taxifolin, and pomegranate fruit (P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9a9549ad48a3268f9fdd02cd2d87891
https://doi.org/10.1016/j.fitote.2012.06.004
https://doi.org/10.1016/j.fitote.2012.06.004
Autor:
Michelle Kraus, Jay M. Wendling, Olga V. Nemirovskiy, John W. Rains, Vincent Peterkin, Laura E. Zawadzke, Hideji Fujiwara, Ciarán N. Cronin, Troii Hall, Tom Kasten, Maureen K. Highkin, Gina M. Jerome, Arthur J. Wittwer, Matthew P. Yates, Shinji Ogawa, Jeffrey A. Scholten, Jill Chrencik, Marek M. Nagiec, Matthew D. McReynolds, Kaliapan Iyanar, Mark E. Schnute, Kristin Cukyne, Matthew J. Saabye, Richard M. Broadus
Publikováno v:
Biochemical Journal. 444:79-88
SphK (sphingosine kinase) is the major source of the bioactive lipid and GPCR (G-protein-coupled receptor) agonist S1P (sphingosine 1-phosphate). S1P promotes cell growth, survival and migration, and is a key regulator of lymphocyte trafficking. Inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c29039f87435103ee01d57e1663842f
https://doi.org/10.1042/bj20111929
https://doi.org/10.1042/bj20111929