Výsledky vyhledávání - "Jeffrey A. Sample"

Differential Effects of Protein Kinase C Isoform Activation in Endothelin-Mediated Myocyte Contractile Dysfunction With Cardioplegic Arrest and Reperfusion

Autor: Claire M. Allen, Amy H. Leonardi, Julie E. McLean, Francis G. Spinale, Jeffrey A. Sample, Kimberly A. Apple, Rupak Mukherjee, Brooke Schaeffer, Rebecca L. Murphy, Jennifer W. Hendrick, Anne M. Deschamps, Christina E. Squires, Robert E. Stroud

Publikováno v: The Annals of Thoracic Surgery. 82:664-671

Increased myocardial interstitial levels of endothelin (ET) occur during cardioplegic arrest (CA) and may contribute to contractile dysfunction. Endothelin receptor transduction involves the protein kinase-C (PKC) family comprised of multiple isoform

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb6ffce213204f83ea5e202ed79b190f
https://doi.org/10.1016/j.athoracsur.2006.03.021

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Trafficking of the Membrane Type-1 Matrix Metalloproteinase in Ischemia and Reperfusion

Autor: Anne M. Deschamps, Christina E. Squires, Joseph T. Mingoia, Jeffrey A. Sample, David M. McClister, William M. Yarbrough, Rebecca A. Allen, Kathryn B. Dowdy, Francis G. Spinale, Julie E. McLean, Rupak Mukherjee

Publikováno v: Circulation. 111:1166-1174

Background— The matrix metalloproteinases (MMPs) contribute to regional remodeling after prolonged periods of ischemia and reperfusion (I/R), but specific MMP types activated during this process remain poorly understood. A novel class, the membrane

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56df6ba97d4da9ac1504ed66b656b24d
https://doi.org/10.1161/01.cir.0000157149.71297.3a

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Effects of Adrenomedullin on Human Myocyte Contractile Function and β-Adrenergic Response

Autor: Rupak Mukherjee, Jeffrey A. Sample, James L. Zellner, Francis G. Spinale, Donald B. Hoover, Kathryn B. Dowdy, Marlina M. Multani

Publikováno v: Journal of Cardiovascular Pharmacology and Therapeutics. 7:235-240

Background: Adrenomedullin has been demonstrated to cause systemic vasodilation, and increased plasma adrenomedullin levels have been observed in cardiovascular disease states such as heart failure. While adrenomedullin receptors have been localized

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a41c973d5c9e61ac4691a232aa72f98
https://doi.org/10.1177/107424840200700406

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Cardiorenal Effects of Adenosine Subtype 1 (A1) Receptor Inhibition in an Experimental Model of Heart Failure1

Autor: Jennifer W. Hendrick, Fred A. Crawford, Gladys P Escobar, Jeffrey A. Sample, Glenn Smits, Rupak Mukherjee, David G. Lucas, Francis G. Spinale

Publikováno v: Journal of the American College of Surgeons. 194:603-609

BACKGROUND: Elaboration of a number of bioactive substances, including adenosine, occurs in heart failure (HF). Adenosine, through the adenosine subtype 1 (A 1 ) receptor, can reduce renal perfusion pressure and glomerular filtration rate and increas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0dbac920f35ef819785fa4b8758ad3c6
https://doi.org/10.1016/s1072-7515(02)01136-5

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Expression and activity of pulmonary endothelin converting enzyme in heart failure: Relation to endothelin biosynthesis and receptor distribution

Autor: Francis G. Spinale, Adviye Ergul, Yuhua Zhang, Jeffrey A. Sample, Mary K. King, Ashley L. Grubbs, Cassandra Joffs

Publikováno v: Journal of Cardiac Failure. 7:84-91

Although reduced pulmonary clearance of endothelin-1 (ET-1) has been suggested to contribute to increased circulating levels in congestive heart failure (CHF), the regulation of the pulmonary ET system with CHF remains to be defined. Accordingly, the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9df7307574e3ec2172b840c914f7ffaf
https://doi.org/10.1054/jcaf.2001.22423

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Myocardial interstitial matrix metalloproteinase activity is altered by mechanical changes in LV load: interaction with the angiotensin type 1 receptor

Autor: Jeffrey A. Sample, Robert E. Stroud, Julie E. McLean, Amy H. Leonardi, William M. Yarbrough, Francis G. Spinale, Anne M. Deschamps, Leslie L. Clark, Kimberly A. Apple

Publikováno v: Circulation research. 96(10)

LV myocardial remodeling is a structural hallmark of hypertensive hypertrophy, but molecular mechanisms driving this process are not well understood. The matrix metalloproteinases (MMPs) can cause myocardial remodeling in chronic disease states, but

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97686cec77fd26780a05aa23b5ab6fbc
https://pubmed.ncbi.nlm.nih.gov/15860759

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Caspase inhibition attenuates contractile dysfunction following cardioplegic arrest and rewarming in the setting of left ventricular failure

Autor: William M. Yarbrough, Jennifer W. Hendrick, Amy E. Hardin, Kathryn B. Dowdy, Emily S. Reese, Robert E. Stroud, Jennifer S. Leiser, Rupak Mukherjee, Jeffrey A. Sample, Joseph T. Mingoia, Julie E. McLean, Christina E. Squires, Francis G. Spinale

Publikováno v: Journal of cardiovascular pharmacology. 44(6)

Hyperkalemic cardioplegic arrest (HCA) and rewarming evokes postoperative myocyte contractile dysfunction, a phenomenon of particular importance in settings of preexisting left ventricular (LV) failure. Caspases are intracellular proteolytic enzymes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7056d62fbef7c2518b8ada21fe97e2f4
https://pubmed.ncbi.nlm.nih.gov/15550782

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Modulation of calcium transport improves myocardial contractility and enzyme profiles after prolonged ischemia-reperfusion

Autor: Joseph T. Mingoia, Kathryn B. Dowdy, Fred A. Crawford, William M. Yarbrough, Jeffrey A. Sample, Francis G. Spinale, G. Patricia Escobar, Rupak Mukherjee, Jennifer W. Hendrick, Julie E. McLean

Publikováno v: The Annals of thoracic surgery. 76(6)

Ischemia-reperfusion (IR) injury causes myocardial dysfunction in part through intracellular calcium overload. A recently described pharmacologic compound, MCC-135 (5-methyl-2-[1-piperazinyl] benzenesulfonic acid monohydrate, Mitsubishi Pharma Corpor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad0f9035b7558de1df5682ac65b806c3
https://pubmed.ncbi.nlm.nih.gov/15734461

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Direct inhibition of the sodium/hydrogen exchanger after prolonged regional ischemia improves contractility on reperfusion independent of myocardial viability

Autor: Francis G. Spinale, Joseph T. Mingoia, Jennifer W. Hendrick, G. Patricia Escobar, Julie E. McLean, Robert E. Stroud, Jeffrey A. Sample, Rupak Mukherjee, William M. Yarbrough, Kathryn B. Dowdy

Publikováno v: The Journal of thoracic and cardiovascular surgery. 126(5)

BackgroundA mechanism for myocardial dysfunction after ischemia and reperfusion is Na+/H+ exchanger activation. Although past in vivo models of limited ischemia and reperfusion intervals demonstrate that Na+/H+ exchanger inhibition confers myocardial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37fad61074d04cad380c8bf1df00a411
https://pubmed.ncbi.nlm.nih.gov/14666024

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Myocyte contractility with caspase inhibition and simulated hyperkalemic cardioplegic arrest

Autor: Jennifer W. Hendrick, Jeffrey A. Sample, Emily S. Reese, Amy E. Hardin, William M. Yarbrough, Joseph T. Mingoia, Julie E. McLean, Robert E. Stroud, Francis G. Spinale, Rupak Mukherjee, Jennifer S. Leiser

Publikováno v: The Annals of thoracic surgery. 77(5)

Exposure of left ventricular (LV) myocytes to simulated hyperkalemic cardioplegic arrest (HCA) has been demonstrated to perturb ionic homeostasis and adversely affect myocyte contractility on rewarming. Altered ionic homeostasis can cause cytosolic a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca54337b281481a05f0f02cfcf953e27
https://pubmed.ncbi.nlm.nih.gov/15111166

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