Zobrazeno 1 - 10
of 193
pro vyhledávání: '"Jeffrey A. Ledbetter"'
Autor:
Keith B. Elkon, Mariana J. Kaplan, Luz P. Blanco, Jeffrey A. Ledbetter, Monica M. Purmalek, Suk See De Ravin, Christian Lood, Carolyne K. Smith, Harry L. Malech, Carmelo Carmona-Rivera
Publikováno v:
Nature medicine
Neutrophil extracellular traps (NETs) are implicated in autoimmunity, but how they are generated and their roles in sterile inflammation remain unclear. Ribonucleoprotein immune complexes (RNP ICs), inducers of NETosis, require mitochondrial reactive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f88dc7f356e8b0600301d93951e65dd6
https://doi.org/10.1038/nm.4027
https://doi.org/10.1038/nm.4027
Publikováno v:
Poster Session.
Background and aims Neutrophils play a crucial role in host defense through mechanisms including phagocytosis and formation of neutrophil extracellular traps (NETs), a recently identified neutrophil cell death process in which DNA is extruded togethe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28f80b322a637eafef0c3011b984dbd9
https://doi.org/10.1136/lupus-2017-000215.340
https://doi.org/10.1136/lupus-2017-000215.340
Increased Ribonuclease Expression Reduces Inflammation and Prolongs Survival in TLR7 Transgenic Mice
Autor:
Jessica A. Hamerman, Jeffrey A. Ledbetter, Nalini Agrawal, Thomas H. Teal, Denny Liggitt, Charles E. Alpers, Matthew B. Buechler, Lena Tanaka, Kelly L. Hudkins, Xizhang Sun, Keith B. Elkon, Alice E. Wiedeman, Silvia Bolland
Publikováno v:
The Journal of Immunology. 190:2536-2543
TLR7 activation is implicated in the pathogenesis of systemic lupus erythematosus. Mice that overexpress TLR7 develop a lupus-like disease with autoantibodies and glomerulonephritis and early death. To determine whether degradation of the TLR7 ligand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28023e6f1ab801f1b07e90265f621e57
https://doi.org/10.4049/jimmunol.1202689
https://doi.org/10.4049/jimmunol.1202689
Autor:
Randolph J, Noelle, Meenakshi, Roy, David M, Shepherd, Ivan, Stamenkovico, Jeffrey A, Ledbetter, Alejandro, Aruffo
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 197(11)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b882b0c9f7d81aa81e7ebb3e3f2315e6
https://pubmed.ncbi.nlm.nih.gov/27864549
https://pubmed.ncbi.nlm.nih.gov/27864549
Publikováno v:
The Journal of Experimental Medicine
Lood et al. find that neutrophil TLR7/8 activation shifts neutrophils from phagocytosis of immune complexes to NETosis. Reduced phagocytosis of immune complexes is associated with partial proteolytic cleavage of FcgRIIA. Cleaved FcgRIIA is found in S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6db948f05b01527bf586711f8470c78
https://pubmed.ncbi.nlm.nih.gov/28606989
https://pubmed.ncbi.nlm.nih.gov/28606989
Publikováno v:
The Journal of Immunology. 187:4199-4209
CD180 is homologous to TLR4 and regulates TLR4 signaling, yet its function is unclear. We report that injection of anti-CD180 mAb into mice induced rapid Ig production of all classes and subclasses, with the exception of IgA and IgG2b, with up to 50-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ea72a0857715a6036ba856df3472d82
https://doi.org/10.4049/jimmunol.1100198
https://doi.org/10.4049/jimmunol.1100198
Autor:
Phil Habecker, Lisa McNeill, Che Leung Law, Martha Hayden-Ledbetter, Sonya Buckwalter, Barbara A. Thorne, Dua Raj, Jeffrey A. Ledbetter, Hieu Nguyen
Publikováno v:
International Immunology. 14:389-400
The TCR-CD3 complex consists of the clonotypic disulfide-linked TCRalphabeta or TCRdeltagamma heterodimers, and the invariant CD3delta, epsilon, gamma and zeta chains. We generated plasmid constructs expressing the extracellular domains of the CD3del
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b41fa848e5c36449a6ef44d7954afb4b
https://doi.org/10.1093/intimm/14.4.389
https://doi.org/10.1093/intimm/14.4.389
Autor:
Jeffrey A. Ledbetter, Martha Hayden-Ledbetter, Amber Dahlin, Ingegerd Hellström, Karl Erik Hellström, Nathalie Scholler
Publikováno v:
The Journal of Immunology. 168:2599-2602
We recently found that human CD83, a marker of mature dendritic cells, is an adhesion receptor that binds to resting monocytes and a subset of activated CD8+ T cells. We injected CD83-Ig into mice transplanted with the immunogenic P815 mastocytoma an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::834cca8a9e0f95f287efd68acbd9fecc
https://doi.org/10.4049/jimmunol.168.6.2599
https://doi.org/10.4049/jimmunol.168.6.2599
Autor:
Andre R. Simon, Jeffrey A. Ledbetter, L. LeFlufy, Mick Bailey, Zhe-Sheng Chen, Karin Haverson, Christopher R. Stokes, G. Banfield, Enoc Hollemweguer
Publikováno v:
Veterinary Immunology and Immunopathology. 80:175-186
A total of 27 monoclonal antibodies raised to human targets were included in the present Pig CD workshop. 14 of these had been tested in previous workshops and had been reported as cross-reactive, a further 13 had been reported as cross-reactive duri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14aae23a0c5b0744032bbc2fcdd09b63
https://doi.org/10.1016/s0165-2427(01)00285-9
https://doi.org/10.1016/s0165-2427(01)00285-9