Výsledky vyhledávání - "Jeffrey A. Khan"

Autor: Jeffrey Steven Khan, Andrea Stolar, Mohammad S Alzahri, Nathan G. Allen

Publikováno v: Emergency Medicine Clinics of North America. 33:863-874

The care of patients with a psychiatric emergency is fraught with ethical challenges. Applying ethical reasoning to clinical challenges may help to improve care. Emergency providers should assess decision-making capacity using 4 criteria: communicati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5d4ab7c2c5d619fae851139fddfdb49
https://doi.org/10.1016/j.emc.2015.07.012

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Combinatorial Chemistry in Food Research

Autor: Evgeny N. Vulfson, Jeffrey A Khan

Publikováno v: Combinatorial Chemistry & High Throughput Screening. 6:569-574

This mini-review is concerned with emerging applications of combinatorial chemistry relevant to the needs of the food industry. More specifically, recent advances in the use of combinatorial methods for the identification and analysis of flavours, "f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecfd8fc9774cdb21c3e27a5948da9389
https://doi.org/10.2174/138620703106298734

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Identification of novel polyphenol oxidase inhibitors by enzymatic one-pot synthesis and deconvolution of combinatorial libraries

Autor: Evgeny N. Vulfson, Jeffrey A. Khan, Jérome Tricand de la Gôutte

Publikováno v: Biotechnology and Bioengineering. 75:93-99

The feasibility of enzymatic synthesis of combinatorial libraries using multifunctional starting materials [i.e., 2,4-dihydroxy-N-(2-hydroxyethyl)benzamide, 1; 4-hydroxyphenethyl alcohol, 2; 3,5-dihydroxybenzyl alcohol, 3; and 4-hydroxybenzyl alcohol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b0f2597796287e5dd996d0e2d5aaed87
https://doi.org/10.1002/bit.1168

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Analysis of conformational states ofCandida rugosa lipase in solution: Implications for mechanism of interfacial activation and separation of open and closed forms

Autor: Nigel Turner, Eric C. Needs, Evgeny N. Vulfson, Jeffrey A. Khan

Publikováno v: Biotechnology & Bioengineering. 72:108-118

In this study, an analysis of the transition between the inactive ("closed") and active ("open") conformations of Candida rugosa lipase in solution is performed using irreversible enzyme inhibitors, cyclic saligenin phosphates. It is shown that >90%

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https://doi.org/10.1002/1097-0290(20010105)72:1<108::aid-bit14>3.0.co

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A novel approach to biotransformations in aqueous-organic two-phase systems: Enzymatic synthesis of alkyl β-[D]-glucosides using microencapsulated β-glucosidase

Autor: Jeffrey A. Khan, Douglas B. Sarney, Quan Yi, Evgeny N. Vulfson

Publikováno v: Biotechnology and Bioengineering. 60:385-390

A novel approach to enzymatic biotransformations in aqueous-organic two-phase systems was developed where the aqueous phase was contained within permeable polymeric capsules suspended in organic solvent. Microencapsulated beta-glucosidase, used as a

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https://doi.org/10.1002/(sici)1097-0290(19981105)60:3<385::aid-bit16>3.0.co

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The biosynthesis of the Streptomyces antibiotic bicyclomycin

Autor: Richard B. Herbert, Emma L Bradley, Douglas W. Young, Kenneth W. M. Lawrie, Jeffrey A. Khan, Claire M. Moody

Publikováno v: Tetrahedron Letters. 37:6935-6938

Bicyclomycin 5 is biosynthesized in Streptomyces sapporonensis from L-leucine 2 and L-isoleucine 1 by way of the naturally occurring diketopiperazine 3 and dihydrobicyclomycin 4 . The mode of incorporation of (2 S ,4 R )-[5,5,5- 2 H 3 ]leucine into 5

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https://doi.org/10.1016/0040-4039(96)01521-3

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Synthesis of (2S,4S)- and (2S,4R)-5,5′-dihydroxy[5,5-2H2]leucine by two independent routes

Autor: Piétrick Hudhomme, Xavier Durand, Douglas W. Young, Jeffrey A. Khan

Publikováno v: J. Chem. Soc., Perkin Trans. 1. :1131-1139

In studies directed at discovering the absolute stereochemistry of the reaction catalysed by the enzyme glutamate γ-carboxylase, two independent stereoselective syntheses of (2S,4S)-5,5′-dihydroxy[5,5-2H2]-leucine 4a and its (2S,4R)-diastereoisome

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https://doi.org/10.1039/p19960001131

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Two independent syntheses of (2S,4S)- and (2S,4R)-[5,5-2H2]-5,5′-dihydroxyleucine

Autor: Douglas W. Young, Xavier Durand, Jeffrey A. Khan, Piétrick Hudhomme

Publikováno v: Tetrahedron Letters. 36:1351-1354

Two independent stereoselective syntheses have been used to prepare samples of (2S,4S)-[5,5- 2 H 2 ]-5,5′-dihydroxyleucine ( 3b ) and the (2S,4R)-diastereoisomer ( 3a ). The first synthesis uses (2S)-pyroglutamic acid as starting material and provi

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https://doi.org/10.1016/0040-4039(94)02475-q

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