Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Jeffrey A. Kazzaz"'
Autor:
Jeffrey A. Kazzaz, Marlene S. Strayer, Jichuan Wu, Daniel J. Malone, Hshi-chi Koo, Thomas H. Shaffer, Jonathan M. Davis, David S. Strayer, Marla R. Wolfson
Publikováno v:
Pulmonary Medicine, Vol 2011 (2011)
We compared lung delivery methods of recombinant adenovirus (rAd): (1) rAd suspended in saline, (2) rAd suspended in saline followed by a pulse-chase of a perfluorochemical (PFC) liquid mixture, and (3) a PFC-rAd suspension. Cell uptake, distribution
Externí odkaz:
https://doaj.org/article/4f3fc23b5ca449889e77e4a27e8126e1
Autor:
Alan R. Hauser, Ciara M. Shaver, John D. King, Jeffrey A. Kazzaz, Srinidhi Musunuri, Maureen H. Diaz
Publikováno v:
Infection and Immunity. 76:4414-4421
Hospital-acquired bacterial pneumonia is a common and serious complication of modern medical care. Many aspects of such infections remain unclear, including the mechanisms by which invading pathogens resist clearance by the innate immune response and
Publikováno v:
Free Radical Biology and Medicine. 45:1143-1149
Exposure of lung epithelial cells to hyperoxia results in the generation of excess reactive oxygen species (ROS), cell damage, and production of proinflammatory cytokines (interleukin-8; IL-8). Although activation of the NF-κB and c-Jun N-terminal k
Publikováno v:
Free Radical Biology and Medicine. 42:1517-1523
Hyperoxia and pulmonary infections are well known to increase the risk of acute and chronic lung injury in newborn infants, but it is not clear whether hyperoxia directly increases the risk of pneumonia. The purpose of this study was to examine: (1)
Autor:
James A. Russell, Jeffrey A. Kazzaz, Satyanarayana Lakshminrusimha, Sylvia F. Gugino, Robin H. Steinhorn, Jonathan M. Davis, Stephen Wedgwood
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 174:1370-1377
Hyperoxic ventilation in the management of persistent pulmonary hypertension of the newborn (PPHN) can result in the formation of reactive oxygen species, such as superoxide anions, which can inactivate nitric oxide (NO) and cause vasoconstriction an
Autor:
Jeffrey A. Kazzaz, Thomas H. Shaffer, Eric Hamilton, Ansamma Joseph, Hshi Chi Koo, Marla R. Wolfson, Jonathan M. Davis, Luca Brunelli
Publikováno v:
Pediatric Research. 60:65-70
Previous studies suggest acute lung injury (ALI) in premature newborns is associated with relative deficiency of antioxidant enzymes that may be ameliorated by recombinant human superoxide dismutase (rhSOD). Perfluorochemicals (PFCs) are distributed
Autor:
Yuchi Li, Ansamma Joseph, J. Andres Melendez, Jeffrey A. Kazzaz, Jonathan M. Davis, A. Chander, S. Hella Harkness, Yuko Arita, Hshi-chi Koo
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 290:L978-L986
Reactive oxygen species (ROS) can cause cell injury and death via mitochondrial-dependent pathways, and supplementation with antioxidants has been shown to ameliorate these processes. The c-Jun NH2-terminal kinase (JNK) pathway has been shown to play
Publikováno v:
Current Respiratory Medicine Reviews. 1:197-202
Autor:
Dimitrios Hatzis, Jonathan M. Davis, Yuchi Li, Hshi-chi Koo, Harry Opsimos, Marlene S. Strayer, Philip L. Ballard, Jeffrey A. Kazzaz, Simcha Pollack
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 288:L718-L726
Prolonged exposure to supraphysiological oxygen concentrations results in the generation of reactive oxygen species, which can cause significant lung injury in critically ill patients. Supplementation with human recombinant antioxidant enzymes (AOE)
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 29:779-783
Oxidant insults can lead to apoptotic and nonapoptotic cell death. Lung epithelial cells exposed to high levels of oxygen do not die via apoptosis, but through a much slower, morphologically distinct process involving cell and nuclear swelling. In co