Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Jeffrey A. Haltom"'
Autor:
Joseph W. Guarnieri, Jeffrey A. Haltom, Yentli E. Soto Albrecht, Timothy Lie, Arnold Z. Olali, Gabrielle A. Widjaja, Sujata S. Ranshing, Alessia Angelin, Deborah Murdock, Douglas C. Wallace
Publikováno v:
Pharmacological Research, Vol 204, Iss , Pp 107170- (2024)
To determine the effects of SARS-CoV-2 infection on cellular metabolism, we conducted an exhaustive survey of the cellular metabolic pathways modulated by SARS-CoV-2 infection and confirmed their importance for SARS-CoV-2 propagation by cataloging th
Externí odkaz:
https://doaj.org/article/8d5644fc539c45289de88eb23eb672c6
Autor:
Laura E. Schultz, Jeffrey A. Haltom, Maira P. Almeida, Wesley A. Wierson, Staci L. Solin, Trevor J. Weiss, Jordan A. Helmer, Elizabeth J. Sandquist, Heather R. Shive, Maura McGrail
Publikováno v:
Disease Models & Mechanisms, Vol 11, Iss 6 (2018)
In this study, we used comparative genomics and developmental genetics to identify epigenetic regulators driving oncogenesis in a zebrafish retinoblastoma 1 (rb1) somatic-targeting model of RB1 mutant embryonal brain tumors. Zebrafish rb1 brain tumor
Externí odkaz:
https://doaj.org/article/d7541aa813124c06aaa550fd7eeed8b0
Autor:
Wesley A Wierson, Jordan M Welker, Maira P Almeida, Carla M Mann, Dennis A Webster, Melanie E Torrie, Trevor J Weiss, Sekhar Kambakam, Macy K Vollbrecht, Merrina Lan, Kenna C McKeighan, Jacklyn Levey, Zhitao Ming, Alec Wehmeier, Christopher S Mikelson, Jeffrey A Haltom, Kristen M Kwan, Chi-Bin Chien, Darius Balciunas, Stephen C Ekker, Karl J Clark, Beau R Webber, Branden S Moriarity, Stacy L Solin, Daniel F Carlson, Drena L Dobbs, Maura McGrail, Jeffrey Essner
Publikováno v:
eLife, Vol 9 (2020)
Efficient precision genome engineering requires high frequency and specificity of integration at the genomic target site. Here, we describe a set of resources to streamline reporter gene knock-ins in zebrafish and demonstrate the broader utility of t
Externí odkaz:
https://doaj.org/article/753d782fc25e478bab0a05b01b9d9f77
Publikováno v:
Pharmacogenomics. 22:473-484
Aim: The ERBB gene family plays an important role in cell proliferation and differentiation, and aberrant activations could result in tumorigenesis, which makes this gene family an attractive drug target in the area of precision oncology. Materials &
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::359a86d97852e06357b77abcb46021af
https://doi.org/10.2217/pgs-2020-0158
https://doi.org/10.2217/pgs-2020-0158
Autor:
Stacy L. Solin, Dennis A. Webster, Zhitao Ming, Jacklyn Levey, Merrina Lan, Melanie E. Torrie, Beau R. Webber, Macy K. Vollbrecht, Jeffrey A. Haltom, Chi-Bin Chien, Drena Dobbs, Darius Balciunas, Wesley A. Wierson, Daniel F. Carlson, Kenna C. McKeighan, Sekhar Kambakam, Maira P. Almeida, Trevor J. Weiss, Branden S. Moriarity, Alec Wehmeier, Maura McGrail, Jordan M. Welker, Karl J. Clark, Christopher S. Mikelson, Kristen M. Kwan, Jeffrey J. Essner, Carla M. Mann, Stephen C. Ekker
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e8b0227dd6445e73d5cd41308e5066d
https://doi.org/10.7554/elife.53968.sa2
https://doi.org/10.7554/elife.53968.sa2
Autor:
Jacklyn Levey, Merrina Lan, Carla M. Mann, Maura McGrail, Maira P. Almeida, Beau R. Webber, Kristen M. Kwan, Dennis A. Webster, Trevor J. Weiss, Jeffrey J. Essner, Darius Balciunas, Wesley A. Wierson, Karl J. Clark, Zhitao Ming, Jeffrey A. Haltom, Alec Wehmeier, Stephen C. Ekker, Melanie E. Torrie, Christopher S. Mikelson, Stacy L. Solin, Sekhar Kambakam, Daniel F. Carlson, Macy K. Vollbrecht, Branden S. Moriarity, Jordan M. Welker, Chi Bin Chien, Drena Dobbs, Kenna C. McKeighan
Publikováno v:
eLife, Cambridge : eLife Sciences Publications, Ltd, 2020, vol. 9, art. no. e53968, p. [1-25]
eLife, Vol 9 (2020)
eLife
eLife, Vol 9 (2020)
eLife
Efficient precision genome engineering requires high frequency and specificity of integration at the genomic target site. Here, we describe a set of resources to streamline reporter gene knock-ins in zebrafish and demonstrate the broader utility of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfdaa4c2ba4444b21a6e2fac41b3b74c
https://repository.vu.lt/VU:ELABAPDB141054958&prefLang=en_US
https://repository.vu.lt/VU:ELABAPDB141054958&prefLang=en_US
Autor:
Wesley A. Wierson, Jordan M. Welker, Maira P. Almeida, Carla M. Mann, Dennis A. Webster, Melanie E. Torrie, Trevor J. Weiss, Macy K. Vollbrecht, Merrina Lan, Kenna C. McKeighan, Jacklyn Levey, Zhitao Ming, Alec Wehmeier, Christopher S. Mikelson, Jeffrey A. Haltom, Kristen M. Kwan, Chi-Bin Chien, Darius Balciunas, Stephen C. Ekker, Karl J. Clark, Beau R. Webber, Branden Moriarity, Staci L. Solin, Daniel F. Carlson, Drena L. Dobbs, Maura McGrail, Jeffrey J. Essner
Choices for genome engineering and integration involve high efficiency with little or no target specificity or high specificity with low activity. Here, we describe a targeted integration strategy, called GeneWeld, and a vector series for gene taggin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd33a5971a72194470bd7f917dad8410
Autor:
Jeffrey A. Haltom, Laura E. Schultz, Maura McGrail, Jordan A. Helmer, Elizabeth J. Sandquist, Trevor J. Weiss, Staci L. Solin, Maira P. Almeida, Heather R. Shive, Wesley A. Wierson
Publikováno v:
Disease Models & Mechanisms, Vol 11, Iss 6 (2018)
Disease Models & Mechanisms
Disease Models & Mechanisms
In this study, we used comparative genomics and developmental genetics to identify epigenetic regulators driving oncogenesis in a zebrafish retinoblastoma 1 (rb1) somatic-targeting model of RB1 mutant embryonal brain tumors. Zebrafish rb1 brain tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c034213194652264f2226f6ca559181
http://dmm.biologists.org/content/11/6/dmm034124
http://dmm.biologists.org/content/11/6/dmm034124
In past decade, many reports have demonstrated that tissues in multi-cellular organisms may play important roles to shape the pattern of genome evolution. The tissue-driven hypothesis was then coined, claiming that tissue-specific factor as the commo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d61071338e5be9aea17f524c4d990682
Autor:
Maura McGrail, Heather R. Shive, Jeffrey A. Haltom, Staci L. Solin, Jeffrey J. Essner, Laura E. Schultz
Publikováno v:
Cancer Research. 76:4179-4179
We examined the gene expression signature of zebrafish brain tumors induced by somatic inactivation of the retinoblastoma tumor suppressor rb1 to determine the similarity with human CNS primitive neuroectodermal tumors (PNETs). Childhood CNS PNETs ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::810d213e6fca2860bd3958dd0d64bf69
https://doi.org/10.1158/1538-7445.am2016-4179
https://doi.org/10.1158/1538-7445.am2016-4179