Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Jeffrey A. Gage"'
Autor:
Hongliang Cai, Mark Tomilo, Sandra P. McCurdy, Jeremy T. Starr, Manjinder S. Lall, Mandy Lockard, Mark R. Rauckhorst, Jeffrey W. Gage, Barbachyn Michael R, Huifen Chen, Robert M. Owen, Michael D. Huband, Debra Hanna, Lisa Mullins, Richard J. Sciotti
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5302-5306
Dual inhibitors of bacterial gyrB and parE based on a 5-(2-pyrimidinyl)-imidazo[1,2-a]pyridine template exhibited MICs (microg/mL) of 0.06-64 (Sau), 0.25-64 (MRSA), 0.06-64 (Spy), 0.06-64 (Spn), and 0.03-64 (FQR Spn). Selected examples were efficacio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b0e2071aabace46a4d35df913c184d5
https://doi.org/10.1016/j.bmcl.2009.07.141
https://doi.org/10.1016/j.bmcl.2009.07.141
Publikováno v:
Journal of Antimicrobial Chemotherapy. 41:605-614
Bactericidal activities of clinafloxacin, CI-990 and ciprofloxacin were examined and compared for a small collection of gram-positive and gram-negative pathogens. In-vitro antimicrobial activities were measured by MIC, MBC and time-kill studies; in-v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::158eadec9252fd34b048c3415b2903a3
https://doi.org/10.1093/jac/41.6.605
https://doi.org/10.1093/jac/41.6.605
Autor:
Stephen J. Gracheck, John M. Domagala, Robert C. Reynolds, Gregory E. Roland, Julie A. Dever, Martin A. Shapiro, M R Jacobs, Thomas E. Renau, E. T. Joannides, Joseph P. Sanchez, Jeffrey W. Gage
Publikováno v:
Antimicrobial Agents and Chemotherapy. 40:2363-2368
A series of quinolones with substitutions at the 8 position has been prepared as part of a study to examine the relationship between structural modifications at this position and activity against mycobacteria. The compounds were prepared by procedure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e9e9c9ee18fab082ca1f24d37eb8490
https://doi.org/10.1128/aac.40.10.2363
https://doi.org/10.1128/aac.40.10.2363
Autor:
Martin A. Shapiro, Stephen J. Gracheck, Julie A. Dever, Thomas E. Renau, John M. Domagala, Joseph P. Sanchez, Jeffrey W. Gage
Publikováno v:
Journal of Medicinal Chemistry. 39:729-735
The re-emergence of tuberculosis infections which are resistant to conventional drug therapy has demonstrated the need for alternative chemotherapy against Mycobacterium tuberculosis. As part of a study to optimize the quinolone antibacterials agains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::347e75ca02154daf9ecad9e09912a208
https://doi.org/10.1021/jm9507082
https://doi.org/10.1021/jm9507082
Autor:
Steven L. Yoder, Carl L. Heifetz, Jeffrey W. Gage, Mark A. Meservey, Sara A. Wold, Michael A. Cohen, Gregory E. Roland, Gail B. Mailloux
Publikováno v:
Diagnostic Microbiology and Infectious Disease. 18:41-47
Cefdinir (FK482), a new oral cephalosporin, displayed potent oral activity versus induced infections in mice. In studies using beta-lactamase-nonproducing (beta LAC-) and -producing (beta LAC+) Staphylococcus aureus strains, respective PD50s (in mg/k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45285becaac42dfd4f8494bda6c1c01c
https://doi.org/10.1016/0732-8893(94)90132-5
https://doi.org/10.1016/0732-8893(94)90132-5
Publikováno v:
Drugs. 58:151-153
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd72670588644670117ee4a7317ad424
https://doi.org/10.2165/00003495-199958002-00040
https://doi.org/10.2165/00003495-199958002-00040
Publikováno v:
Skeletal radiology. 37(7)
The purpose of this article is to describe a type of meniscal tear seen on magnetic resonance (MR) imaging, the peripheral vertical tear, and to determine the prevalence of anterior cruciate ligament (ACL) tears in knees with this type of meniscal te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae022d5359cee05912aee5e7f036bd0a
https://pubmed.ncbi.nlm.nih.gov/18463866
https://pubmed.ncbi.nlm.nih.gov/18463866
Autor:
Mark C. Sulavik, Michael A. Cohen, Glenn Gibson, Jeffrey W. Gage, Stephen J. Gracheck, Michael Stier, Edmund L. Ellsworth, Margaret Zurack, Michael D. Huband, Debra Hanna, Laura A. Skerlos
Publikováno v:
Antimicrobial agents and chemotherapy. 51(4)
PD 0305970 and PD 0326448 are new bacterial gyrase and topoisomerase inhibitors (quinazoline-2,4-diones) that possess outstanding in vitro and in vivo activities against a wide spectrum of bacterial species including quinolone- and multidrug-resistan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3a171e6e91e61e44b45c7550bdd82e2
https://pubmed.ncbi.nlm.nih.gov/17261623
https://pubmed.ncbi.nlm.nih.gov/17261623
Autor:
Rajeshwar Singh, E. Themis Joannides, Brian M. Watson, H. D. Hollis Showalter, Steve Dunham, Tuan P. Tran, Dai Q. Nguyen, Michael D. Huband, Michael Stier, Stephen J. Gracheck, Jia Yeu Liu, John M. Domagala, Joseph P. Sanchez, Joel C. Bronstein, Debra Hanna, Jeffrey W. Gage, Martin A. Shapiro, Edmund L. Ellsworth
Publikováno v:
Journal of medicinal chemistry. 49(22)
The 3-aminoquinzolinediones represent a new series of antibacterial agents structurally related to the fluoroquinolones. They are inhibitors of bacterial gyrase and topoisomerase IV and demonstrate clinically useful antibacterial activity against fas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ca424807321e11d888cef562e6a525b
https://pubmed.ncbi.nlm.nih.gov/17064062
https://pubmed.ncbi.nlm.nih.gov/17064062
Autor:
Jeffrey D, Gage, Ray, Kirk
Publikováno v:
The Canadian journal of nursing research = Revue canadienne de recherche en sciences infirmieres. 34(4)
Little is known about how men prepare to become fathers. The purpose of this phenomenological study was to describe first-time fathers' perceptions of preparedness for and the transition to parenthood. Nineteen prospective and new fathers participati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ee0dd951a8cee27e397eba44076f6899
https://pubmed.ncbi.nlm.nih.gov/12619474
https://pubmed.ncbi.nlm.nih.gov/12619474