Zobrazeno 1 - 10
of 212
pro vyhledávání: '"Jeffrey A. Dodge"'
Autor:
Jie Zheng, Mi Ra Chang, Ryan E. Stites, Yong Wang, John B. Bruning, Bruce D. Pascal, Scott J. Novick, Ruben D. Garcia-Ordonez, Keith R. Stayrook, Michael J. Chalmers, Jeffrey A. Dodge, Patrick R. Griffin
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
The vitamin D receptor/retinoid X receptor-α heterodimer (VDRRXRα) regulates bone mineralization. Here the authors employ hydrogen/deuterium exchange (HDX) mass spectrometry to study the conformational dynamics of VDRRXRα and give mechanistic insi
Externí odkaz:
https://doaj.org/article/0af27878e2d34bc4a8b0c9e67ce81c71
Autor:
Joey P Ting, Frances Tung, Stephen Antonysamy, Stephen Wasserman, Spencer B Jones, Feiyu F Zhang, Alfonso Espada, Howard Broughton, Michael J Chalmers, Michael E Woodman, Holly A Bina, Jeffrey A Dodge, Jordi Benach, Aiping Zhang, Christopher Groshong, Danalyn Manglicmot, Marijane Russell, Sepideh Afshar
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0190850 (2018)
To date, IL-17A antibodies remain the only therapeutic approach to correct the abnormal activation of the IL-17A/IL-17R signaling complex. Why is it that despite the remarkable success of IL-17 antibodies, there is no small molecule antagonist of IL-
Externí odkaz:
https://doaj.org/article/9c2e01bb6db44b01a1e0d014dd80e53b
Publikováno v:
Burger's Medicinal Chemistry and Drug Discovery
Osteoporosis is defined as the thinning of bone resulting from the imbalance between bone resorption and bone formation, the two cellular mechanisms that regulate the remodeling of skeletal tissue. This loss of bone ultimately results in an increased
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46a49c603bbe45c8b33b0a1e61f510fc
https://doi.org/10.1002/0471266949.bmc197.pub2
https://doi.org/10.1002/0471266949.bmc197.pub2
Autor:
Cristina Sayago, Nathan C. Fite, Juan J. Carrillo, Feiyu F. Zhang, Isabel C. Gonzalez Valcarcel, Howard B. Broughton, Alfonso Espada, Michael J. Chalmers, Yuewei Qian, Jeffrey Alan Dodge, Jorge Alsina-Fernandez, John Lee
Publikováno v:
ACS Medicinal Chemistry Letters. 9:912-916
[Image: see text] Molecular characterization of the binding epitope of IL-23R and its cognate cytokine IL-23 is paramount to understand the role in autoimmune diseases and to support the discovery of new inhibitors of this protein–protein interacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5cf4b8265a290d94779e6cf9d920e4c
https://doi.org/10.1021/acsmedchemlett.8b00255
https://doi.org/10.1021/acsmedchemlett.8b00255
Autor:
Michael J. Chalmers, Jie Zheng, Ruben D. Garcia-Ordonez, Patrick R. Griffin, Keith R. Stayrook, Ryan Edward Stites, John B. Bruning, Jeffrey Alan Dodge, Bruce D. Pascal, Scott J. Novick, Yong Wang, Mi Ra Chang
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Nature Communications
Nature Communications
The vitamin D receptor/retinoid X receptor-α heterodimer (VDRRXRα) regulates bone mineralization via transcriptional control of osteocalcin (BGLAP) gene and is the receptor for 1α,25-dihydroxyvitamin D3 (1,25D3). However, supra-physiological level
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::108c5fd6a945102809a8af30a65b3215
https://doaj.org/article/0af27878e2d34bc4a8b0c9e67ce81c71
https://doaj.org/article/0af27878e2d34bc4a8b0c9e67ce81c71
Autor:
Michael J. Chalmers, Rubén Haro, Manuel Molina-Martin, Alfonso Espada, Jesús Castañón, Cristina Sayago, Patrick R. Griffin, Leticia Cano, Howard B. Broughton, Bruce D. Pascal, Pablo Redero, Jeffrey Alan Dodge, Ryan Edward Stites, Francisco Perez-Cozar
Publikováno v:
Journal of the American Society for Mass Spectrometry. 30(12)
Hydrogen/deuterium exchange mass spectrometry (HDX-MS) is a biophysical technique well suited to the characterization of protein dynamics and protein–ligand interactions. In order to accurately define the rate of exchange, HDX experiments require t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30d185ed9152e91e48aaebddfaabc33a
https://pubmed.ncbi.nlm.nih.gov/31724102
https://pubmed.ncbi.nlm.nih.gov/31724102
Autor:
Manuel Molina-Martin, Juan F. Espinosa, Patrick R. Griffin, David J. Cummins, Alfonso Espada, Devrishi Goswami, Howard B. Broughton, Ryan Edward Stites, Bruce D. Pascal, Michael J. Chalmers, Jeffrey Alan Dodge, Scott J. Novick
Publikováno v:
Analytical Chemistry. 88:6607-6614
Hydrogen/deuterium exchange coupled with mass spectrometry (HDX-MS) is an information-rich biophysical method for the characterization of protein dynamics. Successful applications of differential HDX-MS include the characterization of protein-ligand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4f4811489bad786b8766bf5b85c872c
https://doi.org/10.1021/acs.analchem.6b01650
https://doi.org/10.1021/acs.analchem.6b01650
Autor:
Thomas P. Burris, Bruce D. Pascal, Ruben D. Garcia-Ordonez, Jeffrey Alan Dodge, Monica A. Istrate, Michael J. Chalmers, Scott A. Busby, Yongjun Wang, Keith R. Stayrook, Patrick R. Griffin, Jun Zhang, Lorri L Burris, John B. Bruning, Douglas J. Kojetin
Publikováno v:
Nature structural & molecular biology
The vitamin D receptor (VDR) functions as an obligate heterodimer in complex with the retinoid X receptor (RXR). These nuclear receptors are multidomain proteins, and it is unclear how various domains interact with one another within the nuclear rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::760a2a0ab05cf6084e88a0f79db27f1b
http://europepmc.org/articles/PMC3087838
http://europepmc.org/articles/PMC3087838
Autor:
Wayne P. Bocchinfuso, Leah M. Helvering, Timothy P. Spicer, Monica A. Istrate, Peter Hodder, Jerrold A. Bernard, Yan Wang, Chahrzad Montrose-Rafizadeh, Naresh Kumar, Patrick R. Griffin, Timothy Ivo Richardson, Jeffrey Alan Dodge, Richard W. Zink
Publikováno v:
SLAS Discovery. 16:183-191
The retinoid acid receptor-related orphan receptors (RORs) represent important targets for the treatment of metabolic and immune disorders. Here the authors describe the application of AlphaScreen(®) technology to develop a high-throughput screening
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86c3f60d6fe73b980a84b7e778c2b283
https://doi.org/10.1177/1087057110389040
https://doi.org/10.1177/1087057110389040
Autor:
Timothy Ivo Richardson, Chahrzad Montrose-Rafizadeh, Scott Alan Jones, Terry L. Moore, Thomas J. Bleisch, John J. Osborne, Charles Willis Lugar, Yu Kuo-Long, Jeffrey Alan Dodge, Pamela K. Shetler, Nita J. Patel, Christian Alexander Clarke, Andrew G. Geiser, Jose Eduardo Lopez, Rachelle J. Sells Galvin, Brian Stephen Muehl, Ying K. Yee, Norman Earle Hughes, Richard W. Zink
Publikováno v:
ACS Medicinal Chemistry Letters. 2:148-153
We report the synthesis and characterization of novel 3-aryl indoles as potent and efficacious progesterone receptor (PR) antagonists with potential for the treatment of uterine fibroids. These compounds demonstrated excellent selectivity over other
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acdb4c9ff42035b27d8602e491bfe9d8
https://doi.org/10.1021/ml100220b
https://doi.org/10.1021/ml100220b