Výsledky vyhledávání - "Jeffrey A. Chao"

Akademický článek

In vivo PAR-CLIP (viP-CLIP) of liver TIAL1 unveils targets regulating cholesterol synthesis and secretion

Autor: Hasan Vatandaslar, Aitor Garzia, Cindy Meyer, Svenja Godbersen, Laura T. L. Brandt, Esther Griesbach, Jeffrey A. Chao, Thomas Tuschl, Markus Stoffel

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)

Abstract System-wide cross-linking and immunoprecipitation (CLIP) approaches have unveiled regulatory mechanisms of RNA-binding proteins (RBPs) mainly in cultured cells due to limitations in the cross-linking efficiency of tissues. Here, we describe

Externí odkaz: https://doaj.org/article/e26c38132e814ef1ac94b1becc3a7648

Zobrazit plný text záznamu

Akademický článek

HDLBP binds ER-targeted mRNAs by multivalent interactions to promote protein synthesis of transmembrane and secreted proteins

Autor: Ulrike Zinnall, Miha Milek, Igor Minia, Carlos H. Vieira-Vieira, Simon Müller, Guido Mastrobuoni, Orsalia-Georgia Hazapis, Simone Del Giudice, David Schwefel, Nadine Bley, Franka Voigt, Jeffrey A. Chao, Stefan Kempa, Stefan Hüttelmaier, Matthias Selbach, Markus Landthaler

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)

RNA binding protein HDLBP (or Vigilin) localizes in the endoplasmic reticulum (ER) membrane. Here the authors show that HDLBP contributes to translation of ER-targeted mRNAs.

Externí odkaz: https://doaj.org/article/540eabd8ef794660a1b89d9588fee403

Zobrazit plný text záznamu

Akademický článek

Plasma Membrane Anchoring and Gag:Gag Multimerization on Viral RNA Are Critical Properties of HIV-1 Gag Required To Mediate Efficient Genome Packaging

Autor: Alice Duchon, Steven Santos, Jianbo Chen, Matthew Brown, Olga A. Nikolaitchik, Sheldon Tai, Jeffrey A. Chao, Eric O. Freed, Vinay K. Pathak, Wei-Shau Hu

Publikováno v: mBio, Vol 12, Iss 6 (2021)

ABSTRACT Human immunodeficiency virus type 1 (HIV-1) Gag selects and packages the HIV RNA genome during virus assembly. However, HIV-1 RNA constitutes only a small fraction of the cellular RNA. Although Gag exhibits a slight preference to viral RNA,

Externí odkaz: https://doaj.org/article/4c52ccae73714e31b32860396048eceb

Zobrazit plný text záznamu

Akademický článek

The structural basis for RNA selectivity by the IMP family of RNA-binding proteins

Autor: Jeetayu Biswas, Vivek L. Patel, Varun Bhaskar, Jeffrey A. Chao, Robert H. Singer, Carolina Eliscovich

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)

ZBP1 and IMP2 belong to the IGF2BP family of RNA-binding proteins. Here the authors employed SELEX, NMR spectroscopy and mutagenesis to characterize the RNA-binding preference of ZBP1 and IMP2.

Externí odkaz: https://doaj.org/article/85ff9493a0c0443292b6df3d1c010479

Zobrazit plný text záznamu

Akademický článek

Dynamics of uS19 C-Terminal Tail during the Translation Elongation Cycle in Human Ribosomes

Autor: Varun Bhaskar, Alexandra Graff-Meyer, Andreas D. Schenk, Simone Cavadini, Ottilie von Loeffelholz, S. Kundhavai Natchiar, Caroline G. Artus-Revel, Hans-Rudolf Hotz, Gabriel Bretones, Bruno P. Klaholz, Jeffrey A. Chao

Publikováno v: Cell Reports, Vol 31, Iss 1, Pp - (2020)

Summary: Ribosomes undergo multiple conformational transitions during translation elongation. Here, we report the high-resolution cryoelectron microscopy (cryo-EM) structure of the human 80S ribosome in the post-decoding pre-translocation state (clas

Externí odkaz: https://doaj.org/article/ab271bc4b7cf423480279f3743614470

Zobrazit plný text záznamu

Akademický článek

Single-Molecule Quantification of Translation-Dependent Association of mRNAs with the Endoplasmic Reticulum

Autor: Franka Voigt, Hui Zhang, Xianying A. Cui, Désirée Triebold, Ai Xin Liu, Jan Eglinger, Eliza S. Lee, Jeffrey A. Chao, Alexander F. Palazzo

Publikováno v: Cell Reports, Vol 21, Iss 13, Pp 3740-3753 (2017)

It is well established that mRNAs encoding secretory or membrane-bound proteins are translated on the surface of the endoplasmic reticulum (ER). The extent to which mRNAs that encode cytosolic proteins associate with the ER, however, remains controve

Externí odkaz: https://doaj.org/article/9d4f1d59d8274315879d5847c5e2aba5

Zobrazit plný text záznamu

Akademický článek

An Unbiased Analysis Method to Quantify mRNA Localization Reveals Its Correlation with Cell Motility

Autor: Hye Yoon Park, Tatjana Trcek, Amber L. Wells, Jeffrey A. Chao, Robert H. Singer

Publikováno v: Cell Reports, Vol 1, Iss 2, Pp 179-184 (2012)

Localization of mRNA is a critical mechanism used by a large fraction of transcripts to restrict its translation to specific cellular regions. Although current high-resolution imaging techniques provide ample information, the analysis methods for loc

Externí odkaz: https://doaj.org/article/82f4723be1f64b2ba3ab32c9f7e6ab52

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání