Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Jeffrey A. Bibbs"'
Publikováno v:
Journal of Nuclear Science and Technology. 43:455-460
The hydrolysis of acyl-derivatives with catalysis by bovine pancreatic trypsin generates solvent isotope effects on the rate constant k cat (k HOH cat /k DOD cat ) of around 1.5 to 4, depending on the structure of the substrate. The abbreviated subst
Autor:
K. Barbara Schowen, Jeffrey A. Bibbs, Paul D. Tittel, Richard L. Schowen, Michael P. Garoutte, Bing Wang
Publikováno v:
Berichte der Bunsengesellschaft für physikalische Chemie. 102:573-579
The curvature of proton-inventory functions (rate constants in mixtures of protium and deuterium oxides) for hydrolysis of substrates of varying structure by trypsins from four different sources has been used as a signal of transition-state stabiliza
Publikováno v:
Journal of the American Chemical Society. 115:5138-5144
Activation parameters for the imidazolocatalyzed hydrolysis of bis(4-nitrophenyl) methylphosphonatc (NMN) are ΔH = 44±2 (H 2 O) and 46±2 (D 2 O) kJ/mol and ΔS = -146±5 (H 2 O) and -145±5 (D 2 O) J/mol K. The activation parameters for water-cata
Publikováno v:
Journal of the American Chemical Society. 113:2259-2263
Autor:
James L. Lalonde, Chi-Huey Wong, J. Blair West, Edgar F. Meyer, Jeffrey A. Bibbs, William J. Hennen, Ziyang Zhong
Publikováno v:
Journal of the American Chemical Society. 112:5313-5320
This paper describes the mechanistic investigation of {alpha}-chymotrypsin and (Met{sub 192}-sulfoxide)-{alpha}-chymotrypsin-catalyzed peptide synthesis in a kinetically controlled process (i.e., aminolysis) and the relative stabilities of both enzym
Publikováno v:
Journal of the American Chemical Society. 111:6424-6427
Publikováno v:
Journal of Molecular Catalysis. 47:187-197
Vibrational-analysis modeling techniques have been applied to the hydride transfer step in dehydrogenase-catalyzed reactions which exhibit exalted α-secondary deuterium isotope effects, leading to the conclusion that non-resonant tunneling occurs in
Publikováno v:
MRS Proceedings. 174
Polypeptides with well defined structures have the potential for the development for novel materials [1]. Synthesis of polypeptides suffer from racemization and protection-deprotection problems and has been dependent on the anhydride method using pho