Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Jeffrey A Mayfield"'
Autor:
Jeffrey A Mayfield, Zhong Liang, Garima Agrahari, Shaun W Lee, Deborah L Donahue, Victoria A Ploplis, Francis J Castellino
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e100698 (2014)
The cluster of virulence sensor (CovS)/responder (CovR) two-component operon (CovRS) regulates ∼15% of the genes of the Group A Streptococcal pyogenes (GAS) genome. Bacterial clones containing inactivating mutations in the covS gene have been isola
Externí odkaz:
https://doaj.org/article/34ad268c760145c9bb8b3c83fd5e2b3d
Autor:
Yue Yuan, Yetunde A. Ayinuola, Damini Singh, Olawole Ayinuola, Jeffrey A. Mayfield, Adam Quek, James C. Whisstock, Ruby H.P. Law, Shaun W. Lee, Victoria A. Ploplis, Francis J. Castellino
Publikováno v:
J Struct Biol
VEK50 is a truncated peptide from a Streptococcal pyogenes surface human plasminogen (hPg) binding M-protein (PAM). VEK50 contains the full A-domain of PAM, which is responsible for its low nanomolar binding to hPg. The interaction of VEK50 with krin
Autor:
Victoria A. Ploplis, Francis J. Castellino, Mijoon Lee, Bill Boggess, Katelyn E. Carothers, Jeffrey A. Mayfield, Deborah L. Donahue, Shaun W. Lee, Zhong Liang
Publikováno v:
Journal of Bacteriology
Streptococcus pyogenes (GAS) causes a range of diseases in humans, ranging from mild to severe, and produces many virulence factors in order to be a successful pathogen. One factor produced by many GAS strains is the protease SpeB, which has been stu
Publikováno v:
Biochemical and Biophysical Research Communications. 444:595-598
Cluster 2b streptokinase (SK2b), secreted by invasive skin-trophic strains of Streptococcus pyogenes (GAS), is a human plasminogen (hPg) activator that optimally functions when human plasma hPg is bound, via its kringle-2 domain, to cognizant bacteri
Autor:
Gudrun S. Lukat-Rodgers, Jeffrey A. Mayfield, Kenton R. Rodgers, Jennifer L. DuBois, Béatrice Blanc
Publikováno v:
Biochemistry. 52:6982-6994
Heme-containing chlorite dismutases (Clds) catalyze a highly unusual O–O bond forming reaction. The O–O cleaving reactions of hydrogen peroxide and peracetic acid (PAA) with the Cld from Dechloromonas aromatica (DaCld) were studied to better unde
Autor:
Victoria A. Ploplis, Francis J. Castellino, Jeffrey A. Mayfield, Rashna D. Balsara, Zhong Liang, Garima Agrahari
Publikováno v:
Journal of Biological Chemistry. 288:27494-27504
Group A Streptococcus pyogenes (GAS) strain AP53 is a primary isolate from a patient with necrotizing fasciitis. These AP53 cells contain an inactivating mutation in the sensor component of the cluster of virulence (cov) responder (R)/sensor (S) two-
Autor:
Jeffrey A. Mayfield, Francis J. Castellino, Victoria A. Ploplis, Zhong Liang, William M. McShan, Yun-Juan Bao, Shaun W. Lee
Symmetric genomic rearrangements around replication axes in genomes are commonly observed in prokaryotic genomes, including Group A Streptococcus (GAS). However, asymmetric rearrangements are rare. Our previous studies showed that the hypervirulent i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ef52ba13df7c2ca450c2ed32c540b47
https://europepmc.org/articles/PMC5903213/
https://europepmc.org/articles/PMC5903213/
Autor:
Deborah L. Donahue, Yun-Juan Bao, Francis J. Castellino, Shaun W. Lee, Katelyn E. Carothers, Victoria A. Ploplis, Zhong Liang, Jeffrey A. Mayfield
The genome of an invasive skin-tropic strain (AP53) of serotype M53 group A Streptococcus pyogenes (GAS) is composed of a circular chromosome of 1,860,554 bp and carries genetic markers for infection at skin locales, viz ., emm gene family pattern D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a389ba676fa9bd3d81e40ce1789e66cd
https://europepmc.org/articles/PMC4886759/
https://europepmc.org/articles/PMC4886759/
Autor:
Dustin L Higashi, Jeffrey Luchetti, Victoria A. Ploplis, Brandon L. Ashfeld, Shaun W. Lee, Charles R. Tessier, Francis J. Castellino, Deborah L. Donahue, Jeffrey A. Mayfield, Kevin X. Rodriguez, Nicolas Biais
Publikováno v:
Nature microbiology. 1
Streptococcus pyogenes, or group A Streptococcus (GAS), is a human bacterial pathogen that can manifest as a range of diseases from pharyngitis and impetigo to severe outcomes such as necrotizing fasciitis and toxic shock syndrome. GAS disease remain
Autor:
Yun-Juan Bao, Shaun W. Lee, Jeffrey A. Mayfield, Victoria A. Ploplis, Francis J. Castellino, Zhong Liang
Publikováno v:
Journal of bacteriology. 197(19)
The two-component c ontrol o f v irulence (Cov) regulator (R)-sensor (S) (CovRS) regulates the virulence of Streptococcus pyogenes (group A Streptococcus [GAS]). Inactivation of CovS during infection switches the pathogenicity of GAS to a more invasi