Zobrazeno 1 - 10
of 547
pro vyhledávání: '"Jeffrey A Bluestone"'
Autor:
Theresa L Walunas, Lisa H Butterfield, William J Murphy, Elizabeth M Jaffee, Bart O Roep, Nicholas L Bayless, Jeffrey A Bluestone, Samantha Bucktrout, Christian A Koch, Arlene H Sharpe
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 9 (2021)
Externí odkaz:
https://doaj.org/article/2c74437288b04a82a1e4c572de4bdb74
Publikováno v:
PLoS ONE, Vol 14, Iss 10, p e0217728 (2019)
Regulatory T cells (Tregs) are an immunosuppressive population that are identified based on the stable expression of the fate-determining transcription factor forkhead box P3 (Foxp3). Tregs can be divided into distinct subsets based on whether they d
Externí odkaz:
https://doaj.org/article/523031b6ab2d4d76bedf4d8c8c01d313
Publikováno v:
Frontiers in Immunology, Vol 6 (2016)
Regulatory T cells control unwanted immune responses including those that mediate tolerance to self as well as to foreign antigens. Their mechanisms of action include direct and indirect effects on effector T cells and important functions in tissue r
Externí odkaz:
https://doaj.org/article/28d25b995ebe4966809922ffd1fbe2c3
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e102125 (2014)
Normal tissue architecture is disrupted following injury, as resident tissue cells become damaged and immune cells are recruited to the site of injury. While injury and inflammation are critical to tissue remodeling, the inability to resolve this res
Externí odkaz:
https://doaj.org/article/7b862af778d547098216c0fdb9da0f95
Publikováno v:
Frontiers in Immunology, Vol 4 (2013)
Thymically-derived Foxp3+ regulatory T cells (tTregs) constitute a unique T cell lineage that is essential for maintaining immune tolerance to self and immune homeostasis. However, Foxp3 can also be turned on in conventional T cells as a consequence
Externí odkaz:
https://doaj.org/article/f7448ead5a814f85a5dfd33a3abe6a73
Autor:
Laura C Wieland Brown, Cristina Penaranda, Purna C Kashyap, Brianna B Williams, Jon Clardy, Mitchell Kronenberg, Justin L Sonnenburg, Laurie E Comstock, Jeffrey A Bluestone, Michael A Fischbach
Publikováno v:
PLoS Biology, Vol 11, Iss 7, p e1001610 (2013)
While the human gut microbiota are suspected to produce diffusible small molecules that modulate host signaling pathways, few of these molecules have been identified. Species of Bacteroides and their relatives, which often comprise >50% of the gut co
Externí odkaz:
https://doaj.org/article/0d403bcd19f749a98f8ba57d7d9034cf
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e66282 (2013)
Regulatory T cells (Treg) are integral for immune homeostasis. Here we demonstrate that canonical microRNAs (miRNAs) are required for Treg function because mice with DGCR8-deficient Treg cells spontaneously develop a scurfy-like disease. Using geneti
Externí odkaz:
https://doaj.org/article/27cdf87f5e5e4b56894ceef77ffbff91
Autor:
Lukas T Jeker, Xuyu Zhou, Kseniya Gershberg, Dimitri de Kouchkovsky, Malika M Morar, Gustavo Stadthagen, Anders H Lund, Jeffrey A Bluestone
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e36684 (2012)
MicroRNAs (miRNAs) are crucial for regulatory T cell (Treg) stability and function. We report that microRNA-10a (miR-10a) is expressed in Tregs but not in other T cells including individual thymocyte subsets. Expression profiling in inbred mouse stra
Externí odkaz:
https://doaj.org/article/2130618c004c4436be4393e71590b5da
Autor:
Joshua N Beilke, Craig T Meagher, Karoline Hosiawa, Marine Champsaur, Jeffrey A Bluestone, Lewis L Lanier
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e36011 (2012)
NK cells have been shown to either promote or protect from autoimmune diseases. Several studies have examined the role of receptors preferentially expressed by NK cells in the spontaneous disease of NOD mice or the direct role of NK cells in acute in
Externí odkaz:
https://doaj.org/article/ccc46a911c75458890c4a13ffe66552c
Autor:
Tatiana N Golovina, Tatiana Mikheeva, Todd M Brusko, Bruce R Blazar, Jeffrey A Bluestone, James L Riley
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e15868 (2011)
Natural T regulatory cells (Tregs) are challenging to expand ex vivo, and this has severely hindered in vivo evaluation of their therapeutic potential. All trans retinoic acid (ATRA) plays an important role in mediating immune homeostasis in vivo, an
Externí odkaz:
https://doaj.org/article/42534d5813ec4c6f9a80abf817ac472d