How do terminal modifications of short designed IIKK peptide amphiphiles affect their antifungal activity and biocompatibility?

Autor: Ralf Schweins, Haoning Gong, Jian R. Lu, Jing Zhang, Mingrui Liao, Zongyi Li, Jeffrey Penny

Publikováno v: Lu, J R, Zhang, J, Gong, H, Liao, M, Li, Z, Penny, J & Schweins, R 2022, ' How do terminal modifications of short designed IIKK peptide amphiphiles affect their antifungal activity and biocompatibility? ', Journal of Colloid and Interface Science, vol. 608, pp. 193-206 . https://doi.org/10.1016/j.jcis.2021.09.170

Hypothesis The widespread and prolonged use of antifungal antibiotics has led to the rapid emergence of multidrug resistant Candida species that compromise current treatments. Natural and synthetic antimicrobial peptides (AMPs) offer potential altern

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::123998e0e1642cfdeeae1ca3e6558094
https://doi.org/10.1016/j.jcis.2021.09.170

Are the Cognitive Alterations Present in Children Born From Preeclamptic Pregnancies the Result of Impaired Angiogenesis? Focus on the Potential Role of the VEGF Family

Autor: Evelyn Lara, Jesenia Acurio, José Leon, Jeffrey Penny, Pablo Torres-Vergara, Carlos Escudero

Publikováno v: Frontiers in Physiology, Vol 9 (2018)

Evidence from clinical studies has proposed that children born from preeclamptic women have a higher risk of suffering neurological, psychological, or behavioral alterations. However, to date, the mechanisms behind these outcomes are poorly understoo

Externí odkaz: https://doaj.org/article/7b102f5f03c141e4953c927ae3dbeb17

Resveratrol-mediated cleavage of amyloid β1–42 peptide: potential relevance to Alzheimer's disease

Autor: Sally Freeman, Izzeddin Alsalahat, Sarmad Al-Edresi, Jeffrey Penny, Harmesh Aojula

Publikováno v: Neurobiology of Aging. 94:24-33

Aggregation of amyloid β1–42 (Aβ1–42) peptide within the brain is considered one of the main causes of the neuropathological changes associated with Alzheimer's disease. Resveratrol is a well-known antioxidant but has also been reported to bind

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::193f94ef402c17ab90be812ec3f1c51e
https://doi.org/10.1016/j.neurobiolaging.2020.04.012

Endothelial Cell Activation by Interleukin-1 and Extracellular Matrix Laminin-10 Occurs via the Yap Signalling Pathway

Autor: Emmanuel Pinteaux, Hannah Thurgur, Jeffrey Penny

Background: The extracellular matrix (ECM) plays an important role for normal brain functions and homeostasis, and contributes to the inflammatory response and mechanisms of brain repair after acute brain injury. We have previously reported that the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4495a9ddfac48245c072ac112f32764
https://doi.org/10.21203/rs.3.rs-365829/v1

Development of a novel in vitro 3D intestinal model for permeability evaluations

Autor: Jian R. Lu, Jing Zhang, Jeffrey Penny

Publikováno v: Zhang, J, Penny, J & Lu, J R 2020, ' Development of a novel in vitro 3D intestinal model for permeability evaluations ', International Journal of Food Sciences and Nutrition . https://doi.org/10.1080/09637486.2019.1700940

In this work, a new three-dimensional (3D) in vitro cell model was described, which was comprised of an epithelium, a subepithelial fibroblast network and an extracellular matrix, thereby more closely mimicking the morphology of the small intestine.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3608afbfdf7d454379c82bab0280dac7
https://www.research.manchester.ac.uk/portal/en/publications/development-of-a-novel-in-vitro-3d-intestinal-model-for-permeability-evaluations(208d0632-18bf-46d1-9651-6975566590cf).html