Zobrazeno 1 - 10
of 147
pro vyhledávání: '"Jeffrey, Conn P"'
Autor:
James P. Bauer, Sarah L. Rader, Max E. Joffe, Wooseok Kwon, Juliana Quay, Leann Seanez, Chengwen Zhou, P. Jeffrey Conn, Alan S. Lewis
Publikováno v:
Biological Psychiatry Global Open Science, Vol 1, Iss 2, Pp 101-111 (2021)
Background: The anterior hippocampus of individuals with early psychosis or schizophrenia is hyperactive, as is the ventral hippocampus in many rodent models for schizophrenia risk. Mossy cells (MCs) of the ventral dentate gyrus (DG) densely project
Externí odkaz:
https://doaj.org/article/8a9ca9a844ee44ec836d967e7a3b4137
Autor:
James Maksymetz, Nellie E. Byun, Deborah J. Luessen, Brianna Li, Robert L. Barry, John C. Gore, Colleen M. Niswender, Craig W. Lindsley, Max E. Joffe, P. Jeffrey Conn
Publikováno v:
Cell Reports, Vol 37, Iss 5, Pp 109950- (2021)
Summary: Evidence for prefrontal cortical (PFC) GABAergic dysfunction is one of the most consistent findings in schizophrenia and may contribute to cognitive deficits. Recent studies suggest that the mGlu1 subtype of metabotropic glutamate receptor r
Externí odkaz:
https://doaj.org/article/a075ccbe92734d68bafa119211f41b75
Autor:
Christopher C. Presley, Charles K. Perry, Elizabeth S. Childress, Matthew J. Mulder, Vincent B. Luscombe, Alice L. Rodriguez, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley
Publikováno v:
ACS Omega, Vol 4, Iss 7, Pp 12782-12789 (2019)
Externí odkaz:
https://doaj.org/article/5fdf499332094c6c9828c3faab3a798f
Autor:
Nicole M. Fisher, Aqeela AlHashim, Aditi B. Buch, Hana Badivuku, Manar M. Samman, Kelly M. Weiss, Gabriela I. Cestero, Mark D. Does, Jerri M. Rook, Craig W. Lindsley, P. Jeffrey Conn, Rocco G. Gogliotti, Colleen M. Niswender
Publikováno v:
JCI Insight, Vol 6, Iss 4 (2021)
The metabotropic glutamate receptor 7 (mGlu7) is a G protein–coupled receptor that has been recently linked to neurodevelopmental disorders. This association is supported by the identification of GRM7 variants in patients with autism spectrum disor
Externí odkaz:
https://doaj.org/article/a777c073552d4febb04f18fa5a845f7b
Publikováno v:
Molecular Brain, Vol 10, Iss 1, Pp 1-19 (2017)
Abstract Support for the N-methyl-d-aspartate receptor (NMDAR) hypofunction hypothesis of schizophrenia has led to increasing focus on restoring proper glutamatergic signaling as an approach for treatment of this devastating disease. The ability of m
Externí odkaz:
https://doaj.org/article/4a1b8eaa1f5846ef86557a168d221c08
Autor:
Daniel Foster, Samantha Yohn, Muhammad Mahmood, Madigan Lavery, Daniel O’Brien, Weimin Peng, P. Jeffrey Conn
Publikováno v:
Journal of Clinical and Translational Science, Vol 3, Pp 19-20 (2019)
OBJECTIVES/SPECIFIC AIMS: The objective of this study was to determine if dopamine signaling is altered in a mouse model displaying excessive self-grooming and further elucidate the potential utility of compounds targeting the striatal DA system in m
Externí odkaz:
https://doaj.org/article/84675a00cb444714bc1fb1821fff7966
Publikováno v:
Neurobiology of Disease, Vol 61, Iss , Pp 55-71 (2014)
The discovery of allosteric modulators of G protein-coupled receptors (GPCRs) provides a promising new strategy with potential for developing novel treatments for a variety of central nervous system (CNS) disorders. Traditional drug discovery efforts
Externí odkaz:
https://doaj.org/article/e76f638f9bd54970b3e6dd14e665dd65
Publikováno v:
In Bioorganic & Medicinal Chemistry 1 May 2010 18(9):3026-3035
Autor:
Yamada, Yousuke, Gilliland, Kristen, Xiang, Zixiu, Haymer, Daniel, Crocker, Katherine E., Loch, Matthew T., Schulte, Michael L., Rodriguez, Alice L., Niswender, Colleen M., Jeffrey Conn, P., Lindsley, Craig W., Melancon, Bruce J.
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 15 October 2021 50
Autor:
Spearing, Paul K., Cho, Hyekyung P., Luscombe, Vincent B., Blobaum, Anna L., Boutaud, Olivier, Engers, Darren W., Rodriguez, Alice L., Niswender, Colleen M., Jeffrey Conn, P., Lindsley, Craig W., Bender, Aaron M.
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 1 September 2021 47